Karl Sylvester
Publication Details
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Wnt-β-catenin signaling protects against hepatic ischemia and reperfusion injury in mice.
Gastroenterology. 2011; (2): 707-18, 718.e1-5
Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepatocellular response to ischemia-reperfusion (I/R) injury has not been determined.
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