Cancer Institute A national cancer institute
designated cancer center

BrianĀ Feldman

Publication Details

  • Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate JOURNAL OF BIOLOGICAL CHEMISTRY Costa, M. J., So, A. Y., Kaasik, K., Krueger, K. C., Pillsbury, M. L., Fu, Y., Ptacek, L. J., Yamamoto, K. R., Feldman, B. J. 2011; 286 (11): 9063-9070

    Abstract:

    Glucocorticoids rapidly and robustly induce cell fate decisions in various multipotent cells, although the precise mechanisms of these important cellular events are not understood. Here we showed that glucocorticoids repressed Per3 expression and that this repression was critical for advancing mesenchymal stem cells to the adipocyte fate. Exogenous expression of Per3 inhibited adipogenesis, whereas knocking out Per3 enhanced that fate. Moreover, we found that PER3 formed a complex with PPAR? and inhibited PPAR?-mediated transcriptional activation via Ppar? response elements. Consistent with these findings, Per3 knock-out mice displayed alterations in body composition, with both increased adipose and decreased muscle tissue compared with wild-type mice. Our findings identify Per3 as potent mediator of cell fate that functions by altering the transcriptional activity of PPAR?.

    View details for DOI 10.1074/jbc.M110.164558

    View details for Web of Science ID 000288247700037

    View details for PubMedID 21228270

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