Cancer Institute A national cancer institute
designated cancer center

Dean W. Felsher

Publication Details

  • TGFß-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. Cell cycle Müller, J., Samans, B., van Riggelen, J., Fagà, G., Peh K N, R., Wei, C., Müller, H., Amati, B., Felsher, D., Eilers, M. 2010; 9 (23): 4622-4626


    Deregulated expression of Myc under the control of an immunoglobulin enhancer induces lymphoma formation in mice. The development of lymphomas is limited by TGF?-dependent senescence and high levels of Myc expression are continuously required to antagonize senescence. The biological processes underlying senescence are not fully resolved. We report here a comprehensive analysis of TGF?-dependent alterations in gene expression when the Myc transgene is switched off. Our data show that Myc-induced target genes are downregulated in a TGF?-independent manner. In contrast, TGF? is required to upregulate a broad spectrum of genes that are characteristic of different T-cell lineages when Myc is turned off. The analysis reveals a significant overlap between these Myc-repressed genes with genes that are targets of polycomb repressive complexes in embryonic stem cells. Therefore, TGF?-dependent senescence is associated with gene expression patterns indicative of abortive cellular differentiation along several lineages.

    View details for PubMedID 21127397

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