Maximilian Diehn, M.D., Ph.D.

Publications

• Association of reactive oxygen species levels and radioresistance in cancer stem cells. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF. Nature. 2009; 458 (7239): 780-3
• Therapeutic implications of the cancer stem cell hypothesis. Diehn M, Cho RW, Clarke MF. Semin Radiat Oncol. 2009; 19 (2): 78-86
• Migration of implanted markers for image-guided lung tumor stereotactic ablative radiotherapy. Hong JC, Eclov NC, Yu Y, Rao AK, Dieterich S, Le QT, Diehn M, Sze DY, Loo BW, Kothary N, Maxim PG. J Appl Clin Med Phys. 2013; 14 (2): 4046
• The optimal use of radiotherapy in small cell lung cancer. Shultz DB, Grecula JC, Hayman J, Diehn M, Loo BW. J Natl Compr Canc Netw. 2013; 11 (1): 107-14
• Intrafraction verification of gated RapidArc by using beam-level kilovoltage X-ray images. Li R, Mok E, Chang DT, Daly M, Loo BW, Diehn M, Le QT, Koong A, Xing L. Int J Radiat Oncol Biol Phys. 2012; 83 (5): e709-15
• Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy. Abelson JA, Murphy JD, Trakul N, Bazan JG, Maxim PG, Graves EE, Quon A, Le QT, Diehn M, Loo BW. Lung Cancer. 2012; 78 (3): 219-24
• Stereotactic ablative radiotherapy for reirradiation of locally recurrent lung tumors. Trakul N, Harris JP, Le QT, Hara WY, Maxim PG, Loo BW, Diehn M. J Thorac Oncol. 2012; 7 (9): 1462-5
• Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Trakul N, Chang CN, Harris J, Chapman C, Rao A, Shen J, Quinlan-Davidson S, Filion EJ, Wakelee HA, Colevas AD, Whyte RI, Dieterich S, Maxim PG, Hristov D, Tran P, Le QT, Loo BW, Diehn M. Int J Radiat Oncol Biol Phys. 2012; 84 (1): 231-7
• High retention and safety of percutaneously implanted endovascular embolization coils as fiducial markers for image-guided stereotactic ablative radiotherapy of pulmonary tumors. Hong JC, Yu Y, Rao AK, Dieterich S, Maxim PG, Le QT, Diehn M, Sze DY, Kothary N, Loo BW. Int J Radiat Oncol Biol Phys. 2011; 81 (1): 85-90
• In Reply to Song et al. Brown M, Loo BW, Diehn M, Carlson DJ. Int J Radiat Oncol Biol Phys. 2011; 81 (4): 1194
• In reply to drs. Koch and evans. Brown JM, Loo BW, Diehn M, Carlson DJ. Int J Radiat Oncol Biol Phys. 2011; 80 (5): 1605
• Influence of Tumor Hypoxia on Stereotactic Ablative Radiotherapy (SABR): Response to Drs. Meyer and Timmerman. Brown M, Loo B, Diehn M, Carlson D. Int J Radiat Oncol Biol Phys. 2011; 79 (5): 1600
• Reducing 4D CT artifacts using optimized sorting based on anatomic similarity. Johnston E, Diehn M, Murphy JD, Loo BW, Maxim PG. Med Phys. 2011; 38 (5): 2424-9
• Tumor volume as a potential imaging-based risk-stratification factor in trimodality therapy for locally advanced non-small cell lung cancer. Kozak MM, Murphy JD, Schipper ML, Donington JS, Zhou L, Whyte RI, Shrager JB, Hoang CD, Bazan J, Maxim PG, Graves EE, Diehn M, Hara WY, Quon A, Le QT, Wakelee HA, Loo BW. J Thorac Oncol. 2011; 6 (5): 920-6
• What the diagnostic radiologist needs to know about radiation oncology. Terezakis SA, Heron DE, Lavigne RF, Diehn M, Loo BW. Radiology. 2011; 261 (1): 30-44
• Metastatic cancer stem cells: an opportunity for improving cancer treatment? Diehn M, Majeti R. Cell Stem Cell. 2010; 6 (6): 502-3
• Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer. Brown JM, Diehn M, Loo BW. Int J Radiat Oncol Biol Phys. 2010; 78 (2): 323-7
• The Myc connection: ES cells and cancer. Rothenberg ME, Clarke MF, Diehn M. Cell. 2010; 143 (2): 184-6
• Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, Diehn M, Liu H, Panula SP, Chiao E, Dirbas FM, Somlo G, Pera RA, Lao K, Clarke MF. Cell. 2009; 138 (3): 592-603
• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (33): 14016-21
• Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Diehn M, Nardini C, Wang DS, McGovern S, Jayaraman M, Liang Y, Aldape K, Cha S, Kuo MD. Proc Natl Acad Sci U S A. 2008; 105 (13): 5213-8
• Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, Gurney A, Lewicki J, Clarke MF. Stem Cells. 2008; 26 (2): 364-71
• Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. Liang Y, Diehn M, Bollen AW, Israel MA, Gupta N. J Neurooncol. 2008; 86 (2): 133-41
• Cancer stem cells and radiotherapy: new insights into tumor radioresistance. Diehn M, Clarke MF. J Natl Cancer Inst. 2006; 98 (24): 1755-7
• Cell-type specific gene expression profiles of leukocytes in human peripheral blood. Palmer C, Diehn M, Alizadeh AA, Brown PO. BMC Genomics. 2006: 7 115
• Genome-scale identification of membrane-associated human mRNAs. Diehn M, Bhattacharya R, Botstein D, Brown PO. PLoS Genet. 2006; 2 (1): e11
• Differential gene expression in anatomical compartments of the human eye. Diehn JJ, Diehn M, Marmor MF, Brown PO. Genome Biol. 2005; 6 (9): R74
• Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA. Proc Natl Acad Sci U S A. 2005; 102 (16): 5814-9
• A method for detecting and correcting feature misidentification on expression microarrays. Tu IP, Schaner M, Diehn M, Sikic BI, Brown PO, Botstein D, Fero MJ. BMC Genomics. 2004: 5 64
• Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. Piedras-Rentería ES, Pyle JL, Diehn M, Glickfeld LL, Harata NC, Cao Y, Kavalali ET, Brown PO, Tsien RW. Proc Natl Acad Sci U S A. 2004; 101 (10): 3609-14
• Gene expression patterns in ovarian carcinomas. Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI. Mol Biol Cell. 2003; 14 (11): 4376-86
• Individuality and variation in gene expression patterns in human blood. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, Brown PO. Proc Natl Acad Sci U S A. 2003; 100 (4): 1896-901
• SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data. Diehn M, Sherlock G, Binkley G, Jin H, Matese JC, Hernandez-Boussard T, Rees CA, Cherry JM, Botstein D, Brown PO, Alizadeh AA. Nucleic Acids Res. 2003; 31 (1): 219-23
• T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. PLoS Biol. 2003; 1 (2): E53
• Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. Proc Natl Acad Sci U S A. 2002; 99 (18): 11796-801
• In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Clément K, Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey JD, Brown PO, Barsh GS, Langin D. Genome Res. 2002; 12 (2): 281-91
• Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA. Proc Natl Acad Sci U S A. 2002; 99 (2): 972-7
• Transcriptional programs activated by exposure of human prostate cancer cells to androgen. DePrimo SE, Diehn M, Nelson JB, Reiter RE, Matese J, Fero M, Tibshirani R, Brown PO, Brooks JD. Genome Biol. 2002; 3 (7): RESEARCH0032
• Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11. Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ. BMC Immunol. 2002: 3 5
• Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Lossos IS, Alizadeh AA, Diehn M, Warnke R, Thorstenson Y, Oefner PJ, Brown PO, Botstein D, Levy R. Proc Natl Acad Sci U S A. 2002; 99 (13): 8886-91
• Comparing functional genomic datasets: lessons from DNA microarray analyses of host-pathogen interactions. Diehn M, Relman DA. Curr Opin Microbiol. 2001; 4 (1): 95-101
• Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. J Biol Chem. 2000; 275 (3): 2219-30
• Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Casagrande R, Stern P, Diehn M, Shamu C, Osario M, Zúñiga M, Brown PO, Ploegh H. Mol Cell. 2000; 5 (4): 729-35
• Examining the living genome in health and disease with DNA microarrays. Diehn M, Alizadeh AA, Brown PO. JAMA. 2000; 283 (17): 2298-9
• Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. Diehn M, Eisen MB, Botstein D, Brown PO. Nat Genet. 2000; 25 (1): 58-62