Stefan Heller

Publications

• A novel ion channel formed by interaction of TRPML3 with TRPV5. Guo Z, Grimm C, Becker L, Ricci AJ, Heller S. PLoS One. 2013; 8 (2): e58174
• FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, Yin X, Cao Y, Jin Y, Wang S, Kong Y, Chen Y, Gao J, Heller S, Xu Z. PLoS One. 2013; 8 (2): e56516
• Special issue on inner ear development and regeneration. Heller S, Hear Res. 2013: 297 1-2
• Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG. Development. 2013; 140 (6): 1196-206
• Concise review: Inner ear stem cells--an oxymoron, but why? Ronaghi M, Nasr M, Heller S. Stem Cells. 2012; 30 (1): 69-74
• Oriented collagen as a potential cochlear implant electrode surface coating to achieve directed neurite outgrowth. Volkenstein S, Kirkwood JE, Lai E, Dazert S, Fuller GG, Heller S. Eur Arch Otorhinolaryngol. 2012; 269 (4): 1111-6
• Regenerative medicine for the special senses: restoring the inputs. Bermingham-McDonogh O, Corwin JT, Hauswirth WW, Heller S, Reed R, Reh TA. J Neurosci. 2012; 32 (41): 14053-7
• TRPML2 AND TRPML3 channels: constitutive activity versus activation by low extracellular sodium and small molecules. Grimm C, Joers S, Guo Z, Obukhov AG, Heller S. J Biol Chem. 2012
• Gpr126 is essential for peripheral nerve development and myelination in mammals. Monk KR, Oshima K, Jörs S, Heller S, Talbot WS. Development. 2011; 138 (13): 2673-80
• Intrinsic regenerative potential of murine cochlear supporting cells. Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske RD, Gahlen F, Sinkkonen W, Cheng AG, Oshima K, Heller S. Sci Rep. 2011: 1 26
• Serial analysis of gene expression in the chicken otocyst. Sinkkonen ST, Starlinger V, Galaiya DJ, Laske RD, Myllykangas S, Oshima K, Heller S. J Assoc Res Otolaryngol. 2011; 12 (6): 697-710
• Curing hearing loss: Patient expectations, health care practitioners, and basic science. Oshima K, Suchert S, Blevins NH, Heller S. J Commun Disord. 2010 Jul-Aug; 43 (4): 311-8
• A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation. Lee KP, Nair AV, Grimm C, van Zeeland F, Heller S, Bindels RJ, Hoenderop JG. Cell Calcium. 2010; 48 (5): 275-87
• Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. Jörs S, Grimm C, Becker L, Heller S. PLoS One. 2010; 5 (12): e14317
• Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Oshima K, Shin K, Diensthuber M, Peng AW, Ricci AJ, Heller S. Cell. 2010; 141 (4): 704-16
• PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23. Xu Z, Oshima K, Heller S. BMC Cell Biol. 2010: 11 80
• Small molecule activators of TRPML3. Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S. Chem Biol. 2010; 17 (2): 135-48
• [Characterization of stem cells derived from the neonatal auditory sensory epithelium]. Diensthuber M, Heller S. HNO. 2010; 58 (11): 1056, 1058, 1060-6
• Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. BMC Neurosci. 2009: 10 122
• Isolation of sphere-forming stem cells from the mouse inner ear. Oshima K, Senn P, Heller S. Methods Mol Biol. 2009: 493 141-62
• Life and death of sensory hair cells expressing constitutively active TRPML3. Grimm C, Jörs S, Heller S. J Biol Chem. 2009; 284 (20): 13823-31
• Quo vadis, hair cell regeneration? Brigande JV, Heller S. Nat Neurosci. 2009; 12 (6): 679-85
• Rethinking how hearing happens. Xu Z, Ricci AJ, Heller S. Neuron. 2009; 62 (3): 305-7
• Stem/progenitor cells derived from the cochlear sensory epithelium give rise to spheres with distinct morphologies and features. Diensthuber M, Oshima K, Heller S. J Assoc Res Otolaryngol. 2009; 10 (2): 173-90
• The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Samie MA, Grimm C, Evans JA, Curcio-Morelli C, Heller S, Slaugenhaupt SA, Cuajungco MP. Pflugers Arch. 2009; 459 (1): 79-91
• Twinfilin 2 regulates actin filament lengths in cochlear stereocilia. Peng AW, Belyantseva IA, Hsu PD, Friedman TB, Heller S. J Neurosci. 2009; 29 (48): 15083-8
• Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development. Huang M, Sage C, Li H, Xiang M, Heller S, Chen ZY. Dev Dyn. 2008; 237 (11): 3305-12
• MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23. Xu Z, Peng AW, Oshima K, Heller S. J Neurosci. 2008; 28 (44): 11269-76
• Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. D'hoedt D, Owsianik G, Prenen J, Cuajungco MP, Grimm C, Heller S, Voets T, Nilius B. J Biol Chem. 2008; 283 (10): 6272-80
• Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. Mizoguchi F, Mizuno A, Hayata T, Nakashima K, Heller S, Ushida T, Sokabe M, Miyasaka N, Suzuki M, Ezura Y, Noda M. J Cell Physiol. 2008; 216 (1): 47-53
• [Stem-cell-based approaches for treating inner ear diseases]. Senn P, Heller S. HNO. 2008; 56 (1): 21-6
• A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Grimm C, Cuajungco MP, van Aken AF, Schnee M, Jörs S, Kros CJ, Ricci AJ, Heller S. Proc Natl Acad Sci U S A. 2007; 104 (49): 19583-8
• Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Jeon SJ, Oshima K, Heller S, Edge AS. Mol Cell Neurosci. 2007; 34 (1): 59-68
• Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. J Assoc Res Otolaryngol. 2007; 8 (1): 18-31
• Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Wu L, Gao X, Brown RC, Heller S, O'Neil RG. Am J Physiol Renal Physiol. 2007; 293 (5): F1699-713
• LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cells. Oshima K, Teo DT, Senn P, Starlinger V, Heller S. BMC Dev Biol. 2007: 7 112
• Robust postmortem survival of murine vestibular and cochlear stem cells. Senn P, Oshima K, Teo D, Grimm C, Heller S. J Assoc Res Otolaryngol. 2007; 8 (2): 194-204
• TRP channels as candidates for hearing and balance abnormalities in vertebrates. Cuajungco MP, Grimm C, Heller S. Biochim Biophys Acta. 2007; 1772 (8): 1022-7
• The potential role of endogenous stem cells in regeneration of the inner ear. Martinez-Monedero R, Oshima K, Heller S, Edge AS. Hear Res. 2007; 227 (1-2): 48-52
• Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. J Neurobiol. 2006; 66 (13): 1489-500
• Generation of inner ear cell types from embryonic stem cells. Rivolta MN, Li H, Heller S. Methods Mol Biol. 2006: 330 71-92
• PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S. J Biol Chem. 2006; 281 (27): 18753-62
• Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons. Martinez-Monedero R, Corrales CE, Cuajungco MP, Heller S, Edge AS. J Neurobiol. 2006; 66 (4): 319-31
• Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro. Zhao Y, Wang Y, Wang Z, Liu H, Shen Y, Li W, Heller S, Li H. Neuroreport. 2006; 17 (2): 121-4
• BMP4 signaling is involved in the generation of inner ear sensory epithelia. Li H, Corrales CE, Wang Z, Zhao Y, Wang Y, Liu H, Heller S. BMC Dev Biol. 2005: 5 16
• Identification of chicken transmembrane channel-like (TMC) genes: expression analysis in the cochlea. Mutai H, Mann S, Heller S. Neuroscience. 2005; 132 (4): 1115-22
• Sound from silence. Oshima K, Heller S. Nat Med. 2005; 11 (3): 249-50
• The mechanosensitive nature of TRPV channels. O'Neil RG, Heller S. Pflugers Arch. 2005; 451 (1): 193-203
• Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. Keresztes G, Martemyanov KA, Krispel CM, Mutai H, Yoo PJ, Maison SF, Burns ME, Arshavsky VY, Heller S. J Biol Chem. 2004; 279 (3): 1581-4
• Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. Li H, Liu H, Corrales CE, Mutai H, Heller S. J Neurobiol. 2004; 60 (1): 61-70
• Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear. Li H, Liu H, Balt S, Mann S, Corrales CE, Heller S. J Comp Neurol. 2004; 468 (1): 125-34
• Islet-1 expression in the developing chicken inner ear. Li H, Liu H, Sage C, Huang M, Chen ZY, Heller S. J Comp Neurol. 2004; 477 (1): 1-10
• Stem cells as therapy for hearing loss. Li H, Corrales CE, Edge A, Heller S. Trends Mol Med. 2004; 10 (7): 309-15
• Vertebrate and invertebrate TRPV-like mechanoreceptors. Mutai H, Heller S. Cell Calcium. 2003 May-Jun; 33 (5-6): 471-8
• Expression of Frizzled genes in the developing chick eye. Fuhrmann S, Stark MR, Heller S. Gene Expr Patterns. 2003; 3 (5): 659-62
• Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system. Keresztes G, Mutai H, Hibino H, Hudspeth AJ, Heller S. Mol Cell Neurosci. 2003; 24 (3): 687-95
• Generation of hair cells by stepwise differentiation of embryonic stem cells. Li H, Roblin G, Liu H, Heller S. Proc Natl Acad Sci U S A. 2003; 100 (23): 13495-500
• Pluripotent stem cells from the adult mouse inner ear. Li H, Liu H, Heller S. Nat Med. 2003; 9 (10): 1293-9
• TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, Mutai H, Heller S. BMC Genomics. 2003; 4 (1): 24
• The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AV, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. J Neurosci. 2003; 23 (32): 10175-81
• A unified nomenclature for the superfamily of TRP cation channels. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. Mol Cell. 2002; 9 (2): 229-31
• Application of physiological genomics to the study of hearing disorders. Heller S, J Physiol. 2002; 543 (Pt 1): 3-12
• Molecular screens for inner ear genes. Heller S, J Neurobiol. 2002; 53 (2): 265-75
• Parvalbumin 3 is an abundant Ca2+ buffer in hair cells. Heller S, Bell AM, Denis CS, Choe Y, Hudspeth AJ. J Assoc Res Otolaryngol. 2002; 3 (4): 488-98
• A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. Robertson NG, Heller S, Lin JS, Resendes BL, Weremowicz S, Denis CS, Bell AM, Hudspeth AJ, Morton CC. Genomics. 2000; 66 (3): 242-8
• Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. Cell. 2000; 103 (3): 525-35
• A transient role for ciliary neurotrophic factor in chick photoreceptor development. Fuhrmann S, Heller S, Rohrer H, Hofmann HD. J Neurobiol. 1998; 37 (4): 672-83
• Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during development of the chick retina. Fuhrmann S, Kirsch M, Heller S, Rohrer H, Hofmann HD. J Comp Neurol. 1998; 400 (2): 244-54
• Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Heller S, Sheane CA, Javed Z, Hudspeth AJ. Proc Natl Acad Sci U S A. 1998; 95 (19): 11400-5
• Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Robertson NG, Lu L, Heller S, Merchant SN, Eavey RD, McKenna M, Nadol JB, Miyamoto RT, Linthicum FH, Lubianca Neto JF, Hudspeth AJ, Seidman CE, Morton CC, Seidman JG. Nat Genet. 1998; 20 (3): 299-303
• The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling. Geissen M, Heller S, Pennica D, Ernsberger U, Rohrer H. Development. 1998; 125 (23): 4791-801
• Two deaf mice, two deaf mice... Heller S, Hudspeth AJ. Nat Med. 1998; 4 (5): 560-1
• Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea. Rosenblatt KP, Sun ZP, Heller S, Hudspeth AJ. Neuron. 1997; 19 (5): 1061-75
• Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia. Holst A, Heller S, Junghans D, Geissen M, Ernsberger U, Rohrer H. Dev Biol. 1997; 191 (1): 1-13
• Extrinsic signals in the developing nervous system: the role of neurokines during neurogenesis. Heller S, Ernsberger U, Rohrer H. Perspect Dev Neurobiol. 1996; 4 (1): 19-34
• Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development. Heller S, Finn TP, Huber J, Nishi R, Geissen M, Püschel AW, Rohrer H. Development. 1995; 121 (8): 2681-93
• GPA and CNTF produce similar effects in sympathetic neurones but differ in receptor binding. Heller S, Huber J, Finn TP, Nishi R, Rohrer H. Neuroreport. 1993; 5 (3): 357-60
• Bioluminescence-based detection of genetically engineered microorganisms in nonsterile river water. Heller S, Bühler S, Kilz S, Mieschendahl M. Microb Releases. 1992; 1 (1): 35-9