Beverly S. Mitchell, M.D.
Publications
- Effect of nucleophosmin1 haploinsufficiency on hematopoietic stem cells. Leukemia. 2012; (4): 853-5
- Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes. Blood. 2012; (24): 4812-8
- Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53. Mol Pharmacol. 2011; (1): 40-8
- Reactive oxygen species regulate nucleostemin oligomerization and protein degradation. J Biol Chem. 2011; (13): 11035-46
- Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin. Cancer Res. 2009; (7): 3004-12
- Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. Leuk Res. 2008; (8): 1268-78
- Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar proteins Leuk Res. 2008; (1): 131-141
- ACCO: ASCO core curriculum outline. J Clin Oncol. 2005; (9): 2049-77
- Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood. 2005; (8): 3058-65
- Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol. 2005; (15): 3396-403
- Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl. Blood. 2005; (8): 3270-7
- The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005; (1): 1-30
- Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part I. In vivo studies. Leuk Res. 2004; (11): 1125-36
- Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer. Clin Cancer Res. 2004; (2): 708-17
- Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A. 2003; (19): 10746-51
- Age and Genetics: How Do Prognostic Factors at Diagnosis Explain Disparities in Acute Myeloid Leukemia? Am J Clin Oncol. 2013
- Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica. 2013; (4): 591-6
- Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. Leukemia. 2012; (5): 893-901
- Understanding disparities in leukemia: a national study. Cancer Causes Control. 2012; (11): 1831-7
- Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. Hematol Oncol. 2011; (3): 157-60
- Synthesis of 2'-deoxy-2'-[18F]fluoro-9-β-D-arabinofuranosylguanine: a novel agent for imaging T-cell activation with PET. Mol Imaging Biol. 2011; (5): 812-8
- Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9). Nucleosides Nucleotides Nucleic Acids. 2008; (6): 704-11
- Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells Biochem Biophys Acta. 2008; (1): 35-40
- Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood. 2007; (12): 5136-42
- Nelarabing induces complete remissions in adults with relapsed or refractory t-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: cancer and leukemia group B study 19801 Blood. 2007; (12): 5136-5142
- Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. Leuk Res. 2006; (8): 1027-36
- Effect of lysosphatidic acid acyltransferase-B inhibition in acute luekemia Leu Res. 2006; (8): 1027-1036
- Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP. J Biol Chem. 2006; (1): 206-12
- On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Hum Mol Genet. 2004; (6): 641-50
- Regulation of equilibrative nucleoside uptake by protein kinase inhibitors. Nucleosides Nucleotides Nucleic Acids. 2004; (8-9): 1445-50
- Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. Blood. 2003; (12): 4958-65
- Inhibition of nucleoside transport by protein kinase inhibitors. J Pharmacol Exp Ther. 2003; (2): 753-60
- Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol. 2003; (18): 6702-12
- The proteasome--an emerging therapeutic target in cancer. N Engl J Med. 2003; (26): 2597-8
- A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Mol Pharmacol. 2002; (3): 463-72
- Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol. 2002; (18): 3891-7
- Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res. 2002; (11): 3100-5
- Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol. 2002; (14): 5194-202
- Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia. Am J Hematol. 2002; (3): 184-90
- Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. J Lab Clin Med. 2002; (2): 84-91
- Inhibition of nucleoside transport by p38 MAPK inhibitors. J Biol Chem. 2002; (32): 28364-7
- Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol. 2002; (22): 4420-7
- Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. J Biol Chem. 2001; (13): 10498-504
- Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response. Clin Cancer Res. 2001; (10): 3263-8
- Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. J Clin Invest. 2000; (4): 599-606
- ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5'-nucleotidase. Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity. Eur J Biochem. 1999; (3): 851-8
- Association of terminal deoxynucleotidyl transferase with Ku. Proc Natl Acad Sci U S A. 1999; (24): 13926-31
- Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination. J Clin Invest. 1999; (6): 833-41
- The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research. Histol Histopathol. 1999; (1): 217-26
- Tissue-specific regulation of the ecto-5'-nucleotidase promoter. Role of the camp response element site in mediating repression by the upstream regulatory region. J Biol Chem. 1999; (32): 22705-12
- Compound GW506U78 in refractory hematologic malignancies: relationship between cellular pharmacokinetics and clinical response. J Clin Oncol. 1998; (11): 3607-15
- Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes Blood. 1998: 2896-2904
- Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. Blood. 1998; (8): 2896-904
- Inosine-5'-monophosphate dehydrogenase: regulation of expression and role in cellular proliferation and T lymphocyte activation. Prog Nucleic Acid Res Mol Biol. 1998: 181-209
- Lectin histochemistry of human leukaemic mast cells (HMC-1) transplanted into severe combined immunodeficient (scid) mice. Acta Histochem. 1998; (1): 1-9
- Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell differentiation: changes in expression pattern of adenosine kinase, adenosine deaminase, and 5'-nucleotidase. J Immunol. 1997; (10): 4947-52
- Cellular delivery of nucleoside diphosphates: a prodrug approach. Pharm Res. 1997; (6): 706-12
- Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. J Biol Chem. 1997; (36): 22913-23
- Regulation of the human inosine monophosphate dehydrogenase type I gene. Utilization of alternative promoters. J Biol Chem. 1997; (7): 4458-66
- A 73 year-old woman with anemia and thrombocytopenia J Am Ger Soc. 1996; (44): 723-726
- Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Proc Natl Acad Sci U S A. 1996; (3): 1232-7
- Inosine monophosphate dehydrogenase expression: transcriptional regulation of the type I and type II genes. Adv Enzyme Regul. 1996: 75-84
- Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity. Cancer Res. 1996; (10): 2343-7
- Transcriptional regulationof the IMPDH type I and II genes Adv Enzyme Regul. 1996; (36): 75-84
- Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med. 1996; (5): 567-73
- Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines. J Clin Invest. 1995; (4): 1660-8
- Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene. J Biol Chem. 1995; (12): 6808-14
- GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Mol Pharmacol. 1995; (5): 948-55
- Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. Biochem Pharmacol. 1995; (9): 1323-9
- Assignment of the human type I IMP dehydrogenase gene (IMPDH1) to chromosome 7q31.3-q32). Genomics. 1994; (1): 179-81
- Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression. J Immunol. 1994; (3): 984-91
- Hereditary overexpression of adenosine deaminase in erythrocytes: studies in erythroid cell lines and transgenic mice. Blood. 1994; (7): 2346-53
- Regulation of low Km (ecto-) 5'-nucleotidase gene expression in leukemic cells. Adv Exp Med Biol. 1994: 683-7
- Structural analysis of the deoxycytidine kinase gene in patients with acute myeloid leukemia and resistance to cytosine arabinoside. Leukemia. 1994; (5): 780-5
- Genomic structure and chromosomal localization of the human deoxycytidine kinase gene. Proc Natl Acad Sci U S A. 1993; (2): 431-4
- Hereditary overexpression of adenosine deaminase in erythrocytes: evidence for a cis-acting mutation. Am J Hum Genet. 1993; (4): 889-93
- IMP dehydrogenase inhibitors as immunomodulators. Ann N Y Acad Sci. 1993: 217-24
- Regulation of human deoxycytidine kinase expression. Adv Enzyme Regul. 1993: 61-8
- Type I inosine monophosphate dehydrogenase: evidence for a single functional gene in mammalian species. Biochem Biophys Res Commun. 1993; (2): 897-901
- Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism. Mol Pharmacol. 1992; (4): 671-6
- Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene. Cancer Res. 1992; (9): 2389-93
- Cloning and expression of human deoxycytidine kinase cDNA. Proc Natl Acad Sci U S A. 1991; (4): 1531-5
- Development of an in vitro model system to study the physiologic effects and toxicities of immunosuppressants Alternative Methods in Toxicology. 1991: 55-61
- Guanine ribonucleotide depletion inhibits T cell activation. Adv Exp Med Biol. 1991: 293-6
- Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine. J Clin Invest. 1991; (3): 940-8
- CD11c (LEU-M5) expression characterizes a B-cell chronic lymphoproliferative disorder with features of both chronic lymphocytic leukemia and hairy cell leukemia. Blood. 1990; (11): 2360-7
- Mutations induced at the hypoxanthine-guanine phosphoribosyltransferase locus of human T-lymphoblasts by perturbations of purine deoxyribonucleoside triphosphate pools. Cancer Res. 1990; (15): 4566-71
- Association of a mature B cell leukemia with a 4p+ chromosomal abnormality: derivation and characterization of a cell line. Leukemia. 1989; (9): 643-7
- Autosomal dominant hemolytic anemia and adenosine deaminase overproduction. Adv Exp Med Biol. 1989: 493-7
- Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989; (23): 6498-502
- Erythrocyte adenosine deaminase overproduction in hereditary hemolytic anemia. Blood. 1989; (1): 448-53
- Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies. Prog Clin Biol Res. 1989: 55-64; discussion 65-8
- Human T-lymphoblast deoxycytidine kinase: purification and properties. Biochemistry. 1989; (1): 114-23
- Identification of an Apa I polymorphism within the human adenosine deaminase gene Nucl Acids Res. 1989; (17): 3626
- Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase. J Biol Chem. 1989; (16): 9359-64
- Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase. Adv Exp Med Biol. 1989: 87-92
- Elevated adenosine deaminase activity and hereditary hemolytic anemia. Evidence for abnormal translational control of protein synthesis. J Clin Invest. 1987; (3): 1001-5
- Genetic expression of adenosine deaminase in human lymphoid malignancies. Blood. 1987; (5): 1376-80
- Molecular basis for elevated adenosine deaminase activity in a kindred with hemolytic anemia J Clin Invest. 1987: 1001-1005
- Transcriptional regulation of the c-myc protooncogene by 1,25-dihydroxyvitamin D3 in HL-60 promyelocytic leukemia cells. J Biol Chem. 1987; (9): 4104-8
- Characterization of arabinosylguanine resistance in a lymphoblastoid cell line. Adv Exp Med Biol. 1986: 605-9
- Biochemical consequences of adenosine deaminase inhibition in vivo. Differential effects in acute and chronic T cell leukemia. Ann N Y Acad Sci. 1985: 129-37
- Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype Br J Haemat. 1985; (61): 125-134
- Differential metabolism of deoxyribonucleosides by leukaemic T cells of immature and mature phenotype. Br J Haematol. 1985; (1): 125-34
- Differential metabolism of guanine nucleosides by human lymphoid cell lines. Proc Soc Exp Biol Med. 1985; (4): 427-31
- Effects of guanine ribonucleotide accumulation on the metabolism and cell cycle of human lymphoid cells. Cancer Res. 1985; (10): 4940-5
- Metabolism and selective cytotoxicity of 9-beta-D-arabinofuranosylguanine in human lymphoblasts. Cancer Res. 1985; (3): 1008-14
- Z-nucleotide accumulation in erythrocytes from Lesch-Nyhan patients. J Clin Invest. 1985; (6): 2416-9
- 2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation. J Clin Invest. 1984; (5): 1640-8
- Erythrocyte ATP a dATP measurements predict toxicity following 2'-deoxycoformycin therapy Cancer Treat Symp. 1984; (2): 67-74
- Plasma membrane 5'-nucleotidase and other purine enzymes in murine lymphocytes. Adv Exp Med Biol. 1984: 129-32
- Purine metabolizing enzymes as predictors of lymphoblast sensitivity to deoxyadenosine. J Lab Clin Med. 1984; (3): 414-24
- Adenosine deaminase deficiency with normal immune function. An acidic enzyme mutation. J Clin Invest. 1983; (2): 483-92
- Alterations in erythrocyte adenine nucleotide pools resulting from 2'-deoxycoformycin therapy. Cancer Res. 1983; (3): 1409-14
- Deoxyribonucleoside triphosphate accumulation by leukemic cells. Blood. 1983; (2): 419-24
- S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine. Cancer Res. 1983; (7): 3451-8
- Adult T-cell leukaemia-lymphoma with unusual phenotype The Lancet (Letter). 1982: 1273-1274
- Deficiencies of adenosine deaminase and purine nucleoside phosphorylase: Implimcations for immunopharmacology Med Gr Rounds. 1982; (1): 85-93
- Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts. Science. 1981; (4525): 1137-9
- ATP depletion as a consequence of adenosine deaminase inhibition in man. Proc Natl Acad Sci U S A. 1980; (10): 6157-61
- An assay of deoxyadenosine and adenosine in human plasma by HPLC. Biochem Med. 1980; (2): 179-84
- Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo. Blood. 1980; (3): 556-9
- Multiple myeloma: current concepts in diagnosis and management. Med Clin North Am. 1980; (4): 729-42
- Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Ann Intern Med. 1980; (6): 826-31
- Treatment of acute lymphoblastic leukemia with 2'-deoxycoformycin: clinical and biochemical consequences of adenosine deaminase inhibition. Cancer Treat Rep. 1979 Nov-Dec; (11-12): 1949-52
- Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase. Proc Natl Acad Sci U S A. 1979; (5): 2434-7
- Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts. Adv Exp Med Biol. 1979: 265-70
- Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts. Adv Exp Med Biol. 1979: 243-59
- Purinogenic immunodeficiency diseases. Differential effects of deoxyadenosine and deoxyguanosine on DNA synthesis in human T lymphoblasts. J Clin Invest. 1979; (5): 1475-84
- Treatment of acute lymphoblastic leukemia with the adenosine deaminase inhibitor 2'-deoxycoformycin. Adv Exp Med Biol. 1979: 347-50
- Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells. Proc Natl Acad Sci U S A. 1978; (10): 5011-4
- Uridine diphosphate galactose 4'-epimerase deficiency Helv Paediat Acta. 1976; (31): 441-454
- Granulocyte and erythroid colony forming cells from rat marrow: Studies of physical and cell cycle characteristics and competition for expression In Erythropoiesis, Nakao K, Fisher J, Pakaku F (Eds) University Park Press. 1975
- Reversal of UDP-galactose 4-epimerase deficiency of human leukocytes in culture Proc Nat Acad Sci (USA). 1975; (72): 5026-5030
- Epidemiological aspects of neoplastic disorders in Israeli migrant population. V. The lymphomas. J Natl Cancer Inst. 1969; (3): 375-81
- The effect of phenylthiourea on melanogenesis of Fundulus Heteroclitus Biological Bulletin. 1966; (131): 398-399
- Sex chromatin determinations in selected cases of developmental sex abnormalities with an assessment of results. Acta Cytol. 1963 May-Jun: 151-8
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