Katrin Chua

Publications

• Cancer: Metabolism in 'the driver's seat. Tasselli L, Chua KF. Nature. 2012; 492 (7429): 362-3
• SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. Nature. 2012; 487 (7405): 114-8
• SIRT6 is required for maintenance of telomere position effect in human cells. Tennen RI, Bua DJ, Wright WE, Chua KF. Nat Commun. 2011: 2 433
• SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF. Cell. 2009; 136 (1): 62-74
• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. Nature. 2008; 452 (7186): 492-6
• A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O. Mol Cell. 2013; 50 (3): 444-56
• Role of SIRT6 in Aging and Reprogramming of Human Induced Pluripotent Stem Cells. Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, Chua KF, Wu JC. J Biol Chem. 2013
• Finding a target for resveratrol. Tennen RI, Michishita-Kioi E, Chua KF. Cell. 2012; 148 (3): 387-9
• Chromatin regulation and genome maintenance by mammalian SIRT6. Tennen RI, Chua KF. Trends Biochem Sci. 2011; 36 (1): 39-46
• Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Nat Immunol. 2011; 12 (1): 29-36
• Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization. Tennen RI, Berber E, Chua KF. Mech Ageing Dev. 2010; 131 (3): 185-92
• Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF. Cell Cycle. 2009; 8 (16): 2664-6
• SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, , Gozani O, Burlingame AL, Bohr VA, Chua KF. Aging. 2009: 1 109-121
• Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P. Mol Cell Biol. 2008; 28 (5): 1688-701
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Cell. 2006; 124 (2): 315-29
• ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. Nature. 2006; 442 (7098): 96-9
• DNA repair, genome stability, and aging. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. Cell. 2005; 120 (4): 497-512
• Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Science. 2004; 303 (5666): 2011-5
• Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Proc Natl Acad Sci U S A. 2003; 100 (19): 10794-9
• Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. Cell. 2003; 114 (3): 359-70
• The influence of transcriptional orientation on endogenous switch region function. Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. Nat Immunol. 2003; 4 (5): 435-41
• Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. Nature. 2003; 422 (6933): 726-30
• Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Proc Natl Acad Sci U S A. 2002; 99 (12): 8173-8
• The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. Chua KF, Alt FW, Manis JP. J Exp Med. 2002; 195 (9): F37-41
• An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Chua K, Reed R. Mol Cell Biol. 2001; 21 (5): 1509-14
• Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Chua K, Reed R. Genes Dev. 1999; 13 (7): 841-50
• The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. Chua K, Reed R. Nature. 1999; 402 (6758): 207-10
• Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Seghezzi W, Chua K, Shanahan F, Gozani O, Reed R, Lees E. Mol Cell Biol. 1998; 18 (8): 4526-36
• Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Genes Dev. 1998; 12 (10): 1409-14
• The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Berglund JA, Chua K, Abovich N, Reed R, Rosbash M. Cell. 1997; 89 (5): 781-7