Chang-Zheng Chen

Publications

• Regulation of immune responses and tolerance: the microRNA perspective. Chen CZ, Schaffert S, Fragoso R, Loh C. Immunol Rev. 2013; 253 (1): 112-28
• MicroRNAs regulate B-cell receptor signaling-induced apoptosis. Kluiver JL, Chen CZ. Genes Immun. 2012; 13 (3): 239-44
• Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. Fragoso R, Mao T, Wang S, Schaffert S, Gong X, Yue S, Luong R, Min H, Yashiro-Ohtani Y, Davis M, Pear W, Chen CZ. PLoS Genet. 2012; 8 (8): e1002855
• Loop nucleotides control primary and mature miRNA function in target recognition and repression. Yue SB, Trujillo RD, Tang Y, O'Gorman WE, Chen CZ. RNA Biol. 2011 Nov-Dec; 8 (6): 1115-23
• MicroRNA programs in normal and aberrant stem and progenitor cells. Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ. Genome Res. 2011; 21 (5): 798-810
• The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML. Cancer Res. 2010; 70 (9): 3833-42
• The potential functions of primary microRNAs in target recognition and repression. Trujillo RD, Yue SB, Tang Y, O'Gorman WE, Chen CZ. EMBO J. 2010; 29 (19): 3272-85
• Identification of the human mature B cell miRNome. Basso K, Sumazin P, Morozov P, Schneider C, Maute RL, Kitagawa Y, Mandelbaum J, Haddad J, Chen CZ, Califano A, Dalla-Favera R. Immunity. 2009; 30 (5): 744-52
• Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ. Development. 2008; 135 (24): 3989-93
• Micromanagement of the immune system by microRNAs. Lodish HF, Zhou B, Liu G, Chen CZ. Nat Rev Immunol. 2008; 8 (2): 120-30
• Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. Liu G, Min H, Yue S, Chen CZ. PLoS One. 2008; 3 (10): e3592
• Dissecting microRNA-mediated gene regulation and function in T-cell development. Mao TK, Chen CZ. Methods Enzymol. 2007: 427 171-89
• miR-181a is an intrinsic modulator of T cell sensitivity and selection. Li QJ, Chau J, Ebert PJ, Sylvester G, Min H, Liu G, Braich R, Manoharan M, Soutschek J, Skare P, Klein LO, Davis MM, Chen CZ. Cell. 2007; 129 (1): 147-61
• Methods for analyzing microRNA expression and function during hematopoietic lineage differentiation. Min H, Chen CZ. Methods Mol Biol. 2006: 342 209-27
• MicroRNAs as oncogenes and tumor suppressors. Chen CZ, N Engl J Med. 2005; 353 (17): 1768-71
• MicroRNAs as regulators of mammalian hematopoiesis. Chen CZ, Lodish HF. Semin Immunol. 2005; 17 (2): 155-65
• MicroRNAs modulate hematopoietic lineage differentiation. Chen CZ, Li L, Lodish HF, Bartel DP. Science. 2004; 303 (5654): 83-6
• Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Bartel DP, Chen CZ. Nat Rev Genet. 2004; 5 (5): 396-400
• The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Chen CZ, Li L, Li M, Lodish HF. Immunity. 2003; 19 (4): 525-33
• Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Chen CZ, Li M, de Graaf D, Monti S, Göttgens B, Sanchez MJ, Lander ES, Golub TR, Green AR, Lodish HF. Proc Natl Acad Sci U S A. 2002; 99 (24): 15468-73
• Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot". Shapiro R, Ruiz-Gutierrez M, Chen CZ. J Mol Biol. 2000; 302 (2): 497-519
• Superadditive and subadditive effects of "hot spot" mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A. Chen CZ, Shapiro R. Biochemistry. 1999; 38 (29): 9273-85
• Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A. Chen CZ, Shapiro R. Proc Natl Acad Sci U S A. 1997; 94 (5): 1761-6