Leonore A. Herzenberg
Publications
- H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease. Proc Natl Acad Sci U S A. 2013; (8): 3005-10
- Our NIH years: a confluence of beginnings. J Biol Chem. 2013; (1): 687-702
- Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc Natl Acad Sci U S A. 2010; (6): 2568-73
- Epitope-specific regulation: the elephant in the bathtub. Nat Immunol. 2007; (8): 783-6
- Interpreting flow cytometry data: a guide for the perplexed. Nat Immunol. 2006; (7): 681-5
- Genetics, FACS, immunology, and redox: a tale of two lives intertwined. Annu Rev Immunol. 2004: 1-31
- A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012; (11): 956-61
- Antigen-specific antibody responses in B-1a and their relationship to natural immunity. Proc Natl Acad Sci U S A. 2012; (14): 5382-7
- Antigen-specific memory in B-1a and its relationship to natural immunity. Proc Natl Acad Sci U S A. 2012; (14): 5388-93
- Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens. J Cyst Fibros. 2012; (6): 502-10
- Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice. PLoS One. 2012; (4): e35733
- Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. Proc Natl Acad Sci U S A. 2012; (14): 5394-8
- Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with Autism Spectrum Disorders. J Autism Dev Disord. 2012; (5): 827-36
- Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012; (3): 565-73
- Reversal of paralysis and reduced inflammation from peripheral administration of β-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis. Sci Transl Med. 2012; (145): 145ra105
- Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol. 2011; (4): 318-27
- Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen. Proc Natl Acad Sci U S A. 2011; (7): 2879-84
- Nerve growth factor: A key local regulator in the pathogenesis of inflammatory arthritis. Arthritis Rheum. 2011; (11): 3243-52
- Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Proc Natl Acad Sci U S A. 2009; (14): 5779-83
- Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia. Proc Natl Acad Sci U S A. 2009; (10): 3941-5
- CD11b expression distinguishes sequential stages of peritoneal B-1 development. Proc Natl Acad Sci U S A. 2008; (13): 5195-200
- Culturing of human peripheral blood cells reveals unsuspected lymphocyte responses relevant to HIV disease. Proc Natl Acad Sci U S A. 2008; (13): 5111-6
- FR255734, a humanized, Fc-Silent, Anti-CD28 antibody, improves psoriasis in the SCID mouse-psoriasis xenograft model. J Invest Dermatol. 2008; (8): 1969-76
- Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Proc Natl Acad Sci U S A. 2008; (11): 4335-9
- B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007; (10): 4191-9
- Division and differentiation of natural antibody-producing cells in mouse spleen. Proc Natl Acad Sci U S A. 2007; (11): 4542-6
- Importance of culturing primary lymphocytes at physiological oxygen levels. Proc Natl Acad Sci U S A. 2007; (11): 4547-52
- Knowledge acquisition and visualization for biomedical research. AMIA Annu Symp Proc. 2007: 1177
- Modern flow cytometry: a practical approach. Clin Lab Med. 2007; (3): 453-68, v
- N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007; (4): 355-9
- Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium. Proteomics. 2007; (2): 180-4
- Unraveling B-1 progenitors. Curr Opin Immunol. 2007; (2): 150-5
- [Phospho-FACS: a powerful tool for exploring intracellular transduction cascades]. Rev Mal Respir. 2007; (8): 955-64
- B cell lineages: documented at last! Nat Immunol. 2006; (3): 225-6
- High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl Acad Sci U S A. 2006; (12): 4628-33
- MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. Cancer Res. 2006; (13): 6598-605
- Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse. Proc Natl Acad Sci U S A. 2006; (16): 6293-8
- Culturing at atmospheric oxygen levels impacts lymphocyte function. Proc Natl Acad Sci U S A. 2005; (10): 3756-9
- Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics. 2005; (1): 215-29
- Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation. 2005; (1): 134-9
- The extracellular microenvironment plays a key role in regulating the redox status of cell surface proteins in HIV-infected subjects. Arch Biochem Biophys. 2005; (1): 26-32
- Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes. Proc Natl Acad Sci U S A. 2004; (9): 2912-7
- Identification of B-cell subsets: an exposition of 11-color (Hi-D) FACS methods. Methods Mol Biol. 2004: 37-58
- New approaches to fluorescence compensation and visualization of FACS data. Clin Immunol. 2004; (3): 277-83
- Ontogeny of gamma delta T cells in humans. J Immunol. 2004; (3): 1637-45
- The E47 transcription factor negatively regulates CD5 expression during thymocyte development. Proc Natl Acad Sci U S A. 2004; (11): 3898-902
- Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol. 2003; (11): 1083-92
- Lymphocyte surface thiol levels. Proc Natl Acad Sci U S A. 2003; (7): 4001-5
- Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway. Proc Natl Acad Sci U S A. 2002; (5): 3007-12
- Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells. Proc Natl Acad Sci U S A. 2002; (4): 2270-4
- Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Mol Immunol. 2002; (10): 773-80
- The history and future of the fluorescence activated cell sorter and flow cytometry: a view from Stanford. Clin Chem. 2002; (10): 1819-27
- Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem Biol. 2001; (1): 71-80
- Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS. Proc Natl Acad Sci U S A. 2001; (5): 2688-93
- Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells. Proc Natl Acad Sci U S A. 2001; (20): 11644-9
- Phycoerythrin-allophycocyanin: a resonance energy transfer fluorochrome for immunofluorescence. Cytometry. 2001; (1): 24-9
- The regulation of CD5 expression in murine T cells. BMC Mol Biol. 2001: 5
- An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. J Immunol. 2000; (9): 4822-30
- B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med. 2000; (2): 271-80
- B-1 cell origins and VH repertoire determination. Curr Top Microbiol Immunol. 2000: 3-13
- B-1 cells: the lineage question revisited. Immunol Rev. 2000: 9-22
- CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proc Natl Acad Sci U S A. 2000; (9): 4766-71
- Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci U S A. 2000; (6): 2680-5
- Monoclonal antibodies and the FACS: complementary tools for immunobiology and medicine. Immunol Today. 2000; (8): 383-90
- N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000; (10): 915-29
- The role of B-1 and B-2 cells in immune protection from influenza virus infection. Curr Top Microbiol Immunol. 2000: 163-9
- Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A. 2000; (26): 14766-71
- An improved monobromobimane assay for glutathione utilizing tris- (2-carboxyethyl)phosphine as the reductant. Anal Biochem. 1999; (1): 107-9
- Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases. Int Immunol. 1999; (11): 1801-10
- Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Proc Natl Acad Sci U S A. 1999; (5): 2250-5
- Nine color eleven parameter immunophenotyping using three laser flow cytometry. Cytometry. 1999; (1): 36-45
- Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A. 1999; (5): 2262-7
- Single cell analysis and selection of living retrovirus vector-corrected mucopolysaccharidosis VII cells using a fluorescence-activated cell sorting-based assay for mammalian beta-glucuronidase enzymatic activity. J Biol Chem. 1999; (2): 657-65
- CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms. J Immunol. 1998; (4): 1710-7
- Pairs of violet-light-excited fluorochromes for flow cytometric analysis. Cytometry. 1998; (4): 435-44
- An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells. J Immunol. 1997; (3): 1175-86
- Detection and isolation of gene-corrected cells in Gaucher disease via a fluorescence-activated cell sorter assay for lysosomal glucocerebrosidase activity. Blood. 1997; (9): 3412-20
- Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation. Semin Immunol. 1997; (6): 389-96
- Frequent occurrence of identical heavy and light chain Ig rearrangements. Int Immunol. 1997; (5): 689-702
- Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci U S A. 1997; (5): 1967-72
- HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J Clin Invest. 1997; (7): 1555-64
- HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals. Int Immunol. 1997; (6): 835-41
- Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. J Exp Med. 1997; (8): 1365-72
- Long-term depletion of naive T cells in patients treated for Hodgkin's disease. Blood. 1997; (9): 3662-72
- Recurrent identical rearrangement and repeated expression of identical heavy and light chains in single anti-phosphatidylcholine B cells. Ann N Y Acad Sci. 1997: 484-8
- Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals. Int Immunol. 1996; (8): 1311-7
- Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains. Proc Natl Acad Sci U S A. 1996; (9): 3947-52
- Changes in antigen densities on leukocyte subsets correlate with progression of HIV disease. Int Immunol. 1996; (1): 1-11
- Cy7PE and Cy7APC: bright new probes for immunofluorescence. Cytometry. 1996; (3): 191-7
- Elevation of plasma thioredoxin levels in HIV-infected individuals. Int Immunol. 1996; (4): 603-11
- Enzyme-generated intracellular fluorescence for single-cell reporter gene analysis utilizing Escherichia coli beta-glucuronidase. Cytometry. 1996; (4): 321-9
- NF-kappa B homodimer binding within the HIV-1 initiator region and interactions with TFII-I. Proc Natl Acad Sci U S A. 1996; (22): 12376-81
- Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins. Proc Natl Acad Sci U S A. 1996; (16): 8508-11
- Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest. 1995; (5): 2054-60
- CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest. 1995; (5): 2061-6
- De novo development and self-replenishment of B cells. Int Immunol. 1995; (1): 55-68
- Development of the antibody repertoire as revealed by single-cell PCR of FACS-sorted B-cell subsets. Ann N Y Acad Sci. 1995: 224-7
- Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med. 1995; (6): 2029-36
- Heterogeneous calcium flux in peripheral T cell subsets revealed by five-color flow cytometry using log-ratio circuitry. Cytometry. 1995; (2): 187-96
- Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy. J Reprod Immunol. 1995; (1): 53-60
- Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Immunity. 1995; (2): 239-50
- Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication. AIDS Res Hum Retroviruses. 1994; (8): 961-7
- Pattern sorting: a computer-controlled multidimensional sorting method using k-d trees. Cytometry. 1994; (4): 357-63
- Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Proc Natl Acad Sci U S A. 1994; (9): 3619-22
- Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. Proc Natl Acad Sci U S A. 1994; (24): 11527-31
- Antioxidants inhibit stimulation of HIV transcription. AIDS Res Hum Retroviruses. 1993; (4): 299-306
- B-cell lineages exist in the mouse. Immunol Today. 1993; (2): 79-83; discussion 88-90
- Beta-galactosidase activity in single differentiating bacterial cells. Proc Natl Acad Sci U S A. 1993; (17): 8194-8
- Disregulation of leukocyte glutathione in AIDS. Ann N Y Acad Sci. 1993: 113-25
- N-acetylcysteine: potential for AIDS therapy. Pharmacology. 1993; (3): 121-9
- Origin of murine B cell lineages. Annu Rev Immunol. 1993: 501-38
- Adoptive transfer of murine B-cell lineages. Ann N Y Acad Sci. 1992: 168-9
- CD20 expression is increased on B lymphocytes from HIV-infected individuals. J Acquir Immune Defic Syndr. 1992; (6): 627-32
- Characteristics and development of the murine B-1b (Ly-1 B sister) cell population. Ann N Y Acad Sci. 1992: 33-43
- Differential development of progenitor activity for three B-cell lineages. Proc Natl Acad Sci U S A. 1992; (8): 3320-4
- Glutathione and immunophenotypes of T and B lymphocytes in HIV-infected individuals. Ann N Y Acad Sci. 1992: 453-63
- Glutathione deficiency and human immunodeficiency virus infection. Lancet. 1992; (8798): 909-12
- Layered evolution in the immune system. A model for the ontogeny and development of multiple lymphocyte lineages. Ann N Y Acad Sci. 1992: 1-9
- Molecular cloning, reconstruction and expression of the gene encoding the alpha-chain of the bovine CD8--definition of three peptide regions conserved across species. Immunology. 1992; (1): 95-102
- N-acetylcysteine: a new approach to anti-HIV therapy. AIDS Res Hum Retroviruses. 1992; (2): 209-17
- The ontogeny and functional characteristics of human B-1 (CD5+ B) cells. Int Immunol. 1992; (2): 243-52
- CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses. Int Immunol. 1991; (9): 933-7
- Heparin alters the expression of different forms of immunoglobulin mu heavy chains and their associated proteins by pre-B cell lines and normal Ly-1 (CD5+) B cells. Int Immunol. 1991; (11): 1117-27
- Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry. 1991; (4): 291-301
- In situ detection of stage-specific genes and enhancers in B cell differentiation via gene-search retroviruses. Adv Exp Med Biol. 1991: 187-200
- N-acetylcysteine inhibits latent HIV expression in chronically infected cells. AIDS Res Hum Retroviruses. 1991; (6): 563-7
- Whole animal cell sorting of Drosophila embryos. Science. 1991; (4989): 81-5
- Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Acad Sci U S A. 1990; (12): 4884-8
- Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals. EMBO J. 1990; (7): 2117-24
- Heparin inhibits EcoRI endonuclease cleavage of DNA at certain EcoRI sites. Nucleic Acids Res. 1990; (11): 3255-60
- Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci U S A. 1990; (24): 9943-7
- Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation. Arthritis Rheum. 1990; (4): 553-62
- Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev. 1990; (10): 1823-34
- The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J. 1990; (13): 4425-33
- The rat B cell system: the anatomical localization of flow cytometry-defined B cell subpopulations. Eur J Immunol. 1990; (7): 1527-34
- Zidovudine (azido dideoxythymidine) inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. J Immunol. 1990; (5): 1705-10
- Murine suppressor T cells: mirage or cloudy reality? Res Immunol. 1989 Mar-Apr; (3): 337-8; discussion 339-45
- A major peritoneal reservoir of precursors for intestinal IgA plasma cells. Immunol Invest. 1989 Jan-May; (1-4): 47-58
- Are Ly-1 B cells important in autoimmune disease? J Autoimmun. 1989: 225-31
- Conventional and Ly-1 B-cell lineages in normal and mu transgenic mice. Cold Spring Harb Symp Quant Biol. 1989: 219-25
- In situ detection of transcriptionally active chromatin and genetic regulatory elements in individual viable mammalian cells. Immunol Suppl. 1989: 74-8; discussion 79
- Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int Immunol. 1989; (1): 75-84
- Permanent alteration of the murine Ly-1 B repertoire due to selective depletion of Ly-1 B cells in neonatal animals. Eur J Immunol. 1989; (3): 501-6
- Toward a layered immune system. Cell. 1989; (6): 953-4
- Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin. Cold Spring Harb Symp Quant Biol. 1989: 767-76
- DNA methylation prevents transfection of genes for specific surface antigens. Proc Natl Acad Sci U S A. 1988; (22): 8391-4
- Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ. Proc Natl Acad Sci U S A. 1988; (8): 2603-7
- Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc Natl Acad Sci U S A. 1988; (19): 7312-6
- Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Eur J Immunol. 1988; (11): 1819-26
- Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc Natl Acad Sci U S A. 1988; (10): 3546-50
- Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 mice. EMBO J. 1988; (12): 3705-10
- Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. EMBO J. 1988; (7): 1989-94
- Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. J Immunol. 1987; (11): 3660-4
- Transfection of genes encoding lymphocyte differentiation antigens: applications in veterinary immunology. Vet Immunol Immunopathol. 1987; (1-4): 291-302
- Immunoglobulin isoantigens (allotypes) in the mouse : V. Characterization of IgM allotypes. Immunogenetics. 1978; (1): 213-30
- GENETICS OF A GAMMA GLOBULIN ISOANTIGEN (ALLOTYPE) IN THE MOUSE. Proc Natl Acad Sci U S A. 1963; (5): 592-8
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