Philip C. Hanawalt
Publications
- Anchoring nascent RNA to the DNA template could interfere with transcription. Biophys J. 2011; (3): 675-84
- DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability. Nucleic Acids Res. 2011; (17): 7444-54
- Mechanisms and implications of transcription blockage by guanine-rich DNA sequences. Proc Natl Acad Sci U S A. 2010; (29): 12816-21
- Transcription-coupled nucleotide excision repair of a gene transcribed by bacteriophage T7 RNA polymerase in Escherichia coli. DNA Repair (Amst). 2010; (9): 958-63
- New applications of the Comet assay: Comet-FISH and transcription-coupled DNA repair. Mutat Res. 2009 Jan-Feb; (1): 44-50
- Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats. Mol Carcinog. 2009; (4): 299-308
- Emerging links between premature ageing and defective DNA repair. Mech Ageing Dev. 2008 Jul-Aug; (7-8): 503-5
- G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II. J Biol Chem. 2008; (19): 12756-62
- Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase. Nucleic Acids Res. 2008; (10): 3163-70
- Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol. 2008; (12): 958-70
- A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription. J Biol Chem. 2007; (44): 32433-41
- Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation. Mutat Res. 2007; (1-2): 3-15
- Paradigms for the three rs: DNA replication, recombination, and repair. Mol Cell. 2007; (5): 702-7
- Transcription coupled nucleotide excision repair in Escherichia coli can be affected by changing the arginine at position 529 of the beta subunit of RNA polymerase. DNA Repair (Amst). 2007; (10): 1434-40
- Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts. DNA Repair (Amst). 2006; (1): 13-22
- Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme. Proc Natl Acad Sci U S A. 2006; (44): 16188-93
- Research collaborations: trial, trust, and truth. Cell. 2006; (5): 823-5
- Role of DNA replication and repair in thymineless death in Escherichia coli. J Bacteriol. 2006; (14): 5286-8
- Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae. DNA Repair (Amst). 2006; (5): 611-7
- Transcription arrest at an abasic site in the transcribed strand of template DNA. Chem Res Toxicol. 2006; (9): 1215-20
- Transcription domain-associated repair in human cells. Mol Cell Biol. 2006; (23): 8722-30
- Transcriptional inhibition by an oxidized abasic site in DNA. Chem Res Toxicol. 2006; (2): 234-41
- Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems. DNA Repair (Amst). 2005; (10): 1075-87
- Density matters: the semiconservative replication of DNA. Proc Natl Acad Sci U S A. 2004; (52): 17889-94
- Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. DNA Repair (Amst). 2004; (5): 483-94
- Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II. Proc Natl Acad Sci U S A. 2004; (19): 7275-80
- Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA. J Biol Chem. 2003; (37): 35791-7
- Four decades of DNA repair: from early insights to current perspectives. Biochimie. 2003; (11): 1043-52
- Functional characterization of global genomic DNA repair and its implications for cancer. Mutat Res. 2003; (2-3): 107-14
- Transcription arrest at a lesion in the transcribed DNA strand in vitro is not affected by a nearby lesion in the opposite strand. J Biol Chem. 2003; (21): 19558-64
- When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease. Bioessays. 2003; (2): 168-73
- Who's on first in the cellular response to DNA damage? Nat Rev Mol Cell Biol. 2003; (5): 361-72
- DNA repair in terminally differentiated cells. DNA Repair (Amst). 2002; (1): 59-75
- Subpathways of nucleotide excision repair and their regulation. Oncogene. 2002; (58): 8949-56
- p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts. Cancer Res. 2002; (18): 5288-94
- Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics. 2001; (1): 41-64
- Controlling the efficiency of excision repair. Mutat Res. 2001; (1): 3-13
- Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. J Biol Chem. 2001; (48): 45367-71
- Revisiting the rodent repairadox. Environ Mol Mutagen. 2001; (2-3): 89-96
- Spatially localized generation of nucleotide sequence-specific DNA damage. Proc Natl Acad Sci U S A. 2001; (20): 11271-6
- The SOS-dependent upregulation of uvrD is not required for efficient nucleotide excision repair of ultraviolet light induced DNA photoproducts in Escherichia coli. Mutat Res. 2001; (4): 319-29
- Binding and photoreactivity of psoralen linked to triple helix-forming oligonucleotides. Photochem Photobiol. 2000; (3): 298-307
- Reduced global genomic repair of ultraviolet light-induced cyclobutane pyrimidine dimers in simian virus 40-transformed human cells. Mol Carcinog. 2000; (1): 17-24
- Regulation of nucleotide excision repair in bacteria and mammalian cells. Cold Spring Harb Symp Quant Biol. 2000: 183-91
- Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol Cell Biol. 2000; (5): 1562-70
- Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Mol Cell. 2000; (4): 737-44
- p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells. Cancer Res. 2000; (3): 517-21
- Effect of DNA lesions on transcription elongation. Biochimie. 1999 Jan-Feb; (1-2): 139-46
- A phylogenomic study of DNA repair genes, proteins, and processes. Mutat Res. 1999; (3): 171-213
- Expression and nucleotide excision repair of a UV-irradiated reporter gene in unirradiated human cells. Mutat Res. 1999; (2): 117-26
- Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc Natl Acad Sci U S A. 1999; (2): 424-8
- RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli. Mol Gen Genet. 1999; (3): 543-51
- Recovery of DNA replication in UV-irradiated Escherichia coli requires both excision repair and recF protein function. J Bacteriol. 1999; (3): 916-22
- Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA. J Biol Chem. 1999; (34): 24124-30
- Triple helix-forming oligonucleotides target psoralen adducts to specific chromosomal sequences in human cells. Nucleic Acids Res. 1999; (24): 4734-42
- Genomic instability: environmental invasion and the enemies within. Mutat Res. 1998; (1-2): 117-25
- Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation. Cancer Res. 1998; (4): 599-603
- Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimers, but not 6-4 photoproducts, in UV-irradiated Escherichia coli. J Bacteriol. 1998; (13): 3345-52
- Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay. Biochim Biophys Acta. 1997; (3): 241-51
- Excision-repair patch lengths are similar for transcription-coupled repair and global genome repair in UV-irradiated human cells. Mutat Res. 1997; (2): 95-105
- Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J Biol Chem. 1997; (44): 28073-80
- Nucleotide sequence context effect of a cyclobutane pyrimidine dimer upon RNA polymerase II transcription. J Biol Chem. 1997; (50): 31719-24
- Role of DNA excision repair gene defects in the etiology of cancer. Curr Top Microbiol Immunol. 1997: 47-70
- recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli. Proc Natl Acad Sci U S A. 1997; (8): 3714-9
- DNA repair deficiencies associated with mutations in genes encoding subunits of transcription initiation factor TFIIH in yeast. Nucleic Acids Res. 1996; (8): 1540-6
- Effects of aminofluorene and acetylaminofluorene DNA adducts on transcriptional elongation by RNA polymerase II. J Biol Chem. 1996; (18): 10588-94
- Fine structure mapping of DNA repair within a 100 kb genomic region in Chinese hamster ovary cells. Mutat Res. 1996; (1): 207-16
- Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli. J Bacteriol. 1996; (5): 1347-50
- Mismatch repair mutants in yeast are not defective in transcription-coupled DNA repair of UV-induced DNA damage. Genetics. 1996; (3): 1127-35
- Recruitment of damaged DNA to the nuclear matrix in hamster cells following ultraviolet irradiation. Nucleic Acids Res. 1996; (15): 2877-84
- Role of transcription-coupled DNA repair in susceptibility to environmental carcinogenesis. Environ Health Perspect. 1996: 547-51
- TFIIH-mediated nucleotide excision repair and initiation of mRNA transcription in an optimized cell-free DNA repair and RNA transcription assay. Nucleic Acids Res. 1996; (18): 3576-82
- DNA repair comes of age. Mutat Res. 1995; (2): 101-13
- DNA repair in the MYC and FMS proto-oncogenes in ultraviolet light-irradiated human HL60 promyelocytic cells during differentiation. Cancer Res. 1995; (2): 336-41
- Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 1995; (14): 2715-23
- Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc Natl Acad Sci U S A. 1995; (19): 8876-80
- Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells. Mutat Res. 1995; (2): 181-92
- Evolution of concepts in DNA repair. Environ Mol Mutagen. 1994: 78-85
- Preferential repair of ultraviolet light-induced DNA damage in the transcribed strand of the human p53 gene. Mol Carcinog. 1994; (2): 105-9
- Removal of cyclobutane pyrimidine dimers from a UV-irradiated shuttle vector introduced into human cells. Somat Cell Mol Genet. 1994; (3): 233-42
- Repair and transcription. Collision or collusion? Curr Biol. 1994; (6): 518-21
- Repair in ribosomal RNA genes is deficient in xeroderma pigmentosum group C and in Cockayne's syndrome cells. Mutat Res. 1994; (4): 179-87
- The COOH terminus of suppressor of stem loop (SSL2/RAD25) in yeast is essential for overall genomic excision repair and transcription-coupled repair. J Biol Chem. 1994; (3): 1852-7
- Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc Natl Acad Sci U S A. 1994; (18): 8502-6
- Transcription-coupled repair of psoralen cross-links but not monoadducts in Chinese hamster ovary cells. Biochemistry. 1994; (35): 10794-9
- "Close-fitting sleeves"--recognition of structural defects in duplex DNA. Mutat Res. 1993; (1): 7-15
- Digestion of damaged DNA by the T7 DNA polymerase-exonuclease. Biochem J. 1993: 451-3
- Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene. Mol Cell Biol. 1993; (2): 970-6
- Lack of transcription-coupled repair in mammalian ribosomal RNA genes. Biochemistry. 1993; (39): 10512-8
- Efficient protection against oxidative DNA damage in chromatin. Mol Carcinog. 1992; (4): 264-9
- Genomic heterogeneity of DNA repair. Role in aging? Ann N Y Acad Sci. 1992: 17-25
- Inhibition of transcription and strand-specific DNA repair by alpha-amanitin in Chinese hamster ovary cells. Mutat Res. 1992; (2): 93-101
- Localized torsional tension in the DNA of human cells. Proc Natl Acad Sci U S A. 1992; (13): 6055-9
- Preferential repair of cyclobutane pyrimidine dimers in the transcribed strand of a gene in yeast chromosomes and plasmids is dependent on transcription. Proc Natl Acad Sci U S A. 1992; (22): 10696-700
- Translesion DNA synthesis in the dihydrofolate reductase domain of UV-irradiated CHO cells. Biochemistry. 1992; (29): 6794-800
- Differential introduction and repair of psoralen photoadducts to DNA in specific human genes. Cancer Res. 1991; (11): 2867-73
- Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing. J Cell Physiol. 1991; (1): 157-73
- Gene-specific DNA repair in terminally differentiating rat myoblasts. Mutat Res. 1991; (2): 123-41
- Heterogeneity of DNA repair at the gene level. Mutat Res. 1991; (2): 203-11
- The genetic defect in the Chinese hamster ovary cell mutant UV61 permits moderate selective repair of cyclobutane pyrimidine dimers in an expressed gene. Mutat Res. 1991; (2): 183-91
- Selective DNA repair in active genes. Acta Biol Hung. 1990; (1-3): 77-91
- Selective DNA repair in expressed genes in mammalian cells. Prog Clin Biol Res. 1990: 213-22
- Transforming growth factor-beta 1 localization in normal and psoriatic epidermal keratinocytes in situ. J Cell Physiol. 1990; (1): 144-50
- Effect of DNA damage on stable transformation of mammalian cells with integrative and episomal plasmids. Mutat Res. 1989 Mar-May; (2-3): 205-20
- Concepts and models for DNA repair: from Escherichia coli to mammalian cells. Environ Mol Mutagen. 1989: 90-8
- DNA damage stimulates human cell transformation by integrative but not episomal Epstein-Barr virus-derived plasmid. Mol Carcinog. 1989; (5): 237-44
- DNA interstrand cross-links promote chromosomal integration of a selected gene in human cells. Mol Cell Biol. 1989; (7): 2897-905
- Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells. Mol Cell Biol. 1989; (4): 1594-603
- Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature. 1989; (6245): 95-8
- Preferential repair of damage in actively transcribed DNA sequences in vivo. Genome. 1989; (2): 605-11
- Repair analysis of mitomycin C-induced DNA crosslinking in ribosomal RNA genes in lymphoblastoid cells from Fanconi's anemia patients. Mutat Res. 1989; (3): 185-92
- Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene. Proc Natl Acad Sci U S A. 1989; (9): 3050-4
- Comparative removal of pyrimidine dimers from human epidermal keratinocytes in vivo and in vitro. J Invest Dermatol. 1988; (4): 349-52
- Enhanced transforming activity of pSV2 plasmids in human cells depends upon the type of damage introduced into the plasmid. Mutat Res. 1988; (2): 97-108
- High-efficiency transformation of bacterial cells by electroporation. J Bacteriol. 1988; (6): 2796-801
- Role of transforming growth factor beta in the maturation of human epidermal keratinocytes. J Invest Dermatol. 1988; (3): 336-41
- Temperature dependent survival of UV-irradiated Escherichia coli K12. Mol Gen Genet. 1988; (2): 198-203
- Enhanced transforming activity of ultraviolet-irradiated pSV2-gpt is due to damage outside the gpt transcription unit. Plasmid. 1987; (2): 135-41
- Preferential DNA repair in expressed genes. Environ Health Perspect. 1987: 9-14
- Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell. 1987; (2): 241-9
Help
Trial Administration