Calvin Kuo

Publications

• Restriction of intestinal stem cell expansion and the regenerative response by YAP. Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD. Nature. 2013; 493 (7430): 106-10
• PDGF-B exploits stromal EPO. McGinnis LM, Kuo CJ. Nat Med. 2012; 18 (1): 22-4
• Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D'Agati VD, Artandi SE. Nat Med. 2012; 18 (1): 111-9
• The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. Cell. 2012; 149 (1): 63-74
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ. Proc Natl Acad Sci U S A. 2012; 109 (2): 466-71
• β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC. Cell. 2012; 151 (7): 1457-73
• Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ. Science. 2010; 330 (6006): 985-9
• Endochondral ossification is required for haematopoietic stem-cell niche formation. Chan CK, Chen CC, Luppen CA, Kim JB, DeBoer AT, Wei K, Helms JA, Kuo CJ, Kraft DL, Weissman IL. Nature. 2009; 457 (7228): 490-4
• Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ. Nat Med. 2009; 15 (6): 701-6
• Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ. Development. 2008; 135 (24): 3989-93
• Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways. Wei K, Kuhnert F, Kuo CJ. J Mol Med (Berl). 2008; 86 (2): 161-9
• Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ. Proc Natl Acad Sci U S A. 2008; 105 (29): 10185-90
• Augmented Wnt signaling in a mammalian model of accelerated aging. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. Science. 2007; 317 (5839): 803-6
• Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. Science. 2007; 317 (5839): 807-10
• VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. Nat Med. 2006; 12 (7): 793-800
• Adenoviral gene transfer with soluble vascular endothelial growth factor receptors impairs angiogenesis and perfusion in a murine model of hindlimb ischemia. Jacobi J, Tam BY, Wu G, Hoffman J, Cooke JP, Kuo CJ. Circulation. 2004; 110 (16): 2424-9
• Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, Yuan J, Nusse R, Kuo CJ. Proc Natl Acad Sci U S A. 2004; 101 (1): 266-71
• Wnts as essential growth factors for the adult small intestine and colon. Hoffman J, Kuhnert F, Davis CR, Kuo CJ. Cell Cycle. 2004; 3 (5): 554-7
• Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Kuo CJ, Farnebo F, Yu EY, Christofferson R, Swearingen RA, Carter R, von Recum HA, Yuan J, Kamihara J, Flynn E, D'Amato R, Folkman J, Mulligan RC. Proc Natl Acad Sci U S A. 2001; 98 (8): 4605-10
• A transcriptional hierarchy involved in mammalian cell-type specification. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE, Crabtree GR. Nature. 1992; 355 (6359): 457-61
• Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. Nature. 1992; 358 (6381): 70-3