Donna Peehl, PhD
Publications
- Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation. J Clin Endocrinol Metab. 2013; (3): E586-94
- Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression. J Urol. 2012; (6): 2158-64
- DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res. 2011; (7): 1017-27
- Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia. Prostate. 2011; (1): 26-31
- Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status. Cancer Lett. 2010; (2): 231-7
- Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry. Cancer Biother Radiopharm. 2010; (4): 439-48
- Targeting monoamine oxidase A in advanced prostate cancer. J Cancer Res Clin Oncol. 2010; (11): 1761-71
- Tissue slice grafts: an in vivo model of human prostate androgen signaling. Am J Pathol. 2010; (1): 229-39
- Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009: 55
- Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. Int J Cancer. 2009; (9): 2050-9
- Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate. Magn Reson Med. 2009; (5): 1091-8
- Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Prostate. 2009; (9): 991-1000
- Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res. 2008; (16): 6831-9
- Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells. Differentiation. 2008; (7): 820-30
- The significance of monoamine oxidase-A expression in high grade prostate cancer. J Urol. 2008; (5): 2206-11
- Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. J Nutr. 2007; (1 Suppl): 205S-210S
- Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity. J Bone Miner Res. 2007: V74-80
- Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis. 2007; (6): 1188-96
- Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues. J Cell Physiol. 2007; (1): 111-21
- Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol. 2007; (3-5): 694-702
- Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein. Nutr Rev. 2007; (8 Pt 2): S121-3
- Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer. Nutr Rev. 2007; (8 Pt 2): S113-5
- Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway. Anticancer Res. 2006 Jul-Aug; (4A): 2525-30
- Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Mol Endocrinol. 2006; (2): 444-58
- Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Res. 2006; (8): 4516-24
- Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology. 2006; (12): 5806-16
- Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells. Prostate. 2006; (2): 218-25
- Comparative gene and protein expression in primary cultures of epithelial cells from benign prostatic hyperplasia and prostate cancer. Cancer Lett. 2005; (2): 213-22
- Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity. Mol Cell Endocrinol. 2005; (1-2): 49-61
- Molecular targets of doxazosin in human prostatic stromal cells. Prostate. 2005; (4): 400-10
- Primary cell cultures as models of prostate cancer development. Endocr Relat Cancer. 2005; (1): 19-47
- Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing. Free Radic Biol Med. 2005; (1): 50-7
- Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Res. 2005; (17): 7917-25
- Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays. Prostate. 2004; (3): 243-51
- Are primary cultures realistic models of prostate cancer? J Cell Biochem. 2004; (1): 185-95
- Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer. J Steroid Biochem Mol Biol. 2004; (4): 307-15
- Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells. Mol Cell Endocrinol. 2004; (1-2): 67-74
- Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis. J Steroid Biochem Mol Biol. 2004; (3): 131-41
- Molecular and cellular pathogenesis of benign prostatic hyperplasia. J Urol. 2004; (5 Pt 1): 1784-91
- Growth of prostatic epithelial and stromal cells in vitro. Methods Mol Med. 2003: 41-57
- Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression. J Cell Biochem. 2003; (2): 363-71
- Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line. Prostate. 2003; (4): 258-67
- Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer. J Nutr. 2003; (7 Suppl): 2461S-2469S
- Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells. J Cell Physiol. 2003; (1): 131-43
- The role of vitamin D and retinoids in controlling prostate cancer progression. Endocr Relat Cancer. 2003; (2): 131-40
- The role of vitamin D in prostate cancer. Recent Results Cancer Res. 2003: 205-21
- Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression. Cancer Epidemiol Biomarkers Prev. 2003; (1): 23-7
- A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology. 2002; (5): 1889-900
- Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res. 2002; (8): 2666-74
- Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. Prostate. 2002; (4): 269-78
- Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. J Urol. 2002; (4 Pt 1): 1583-8
- Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ. 2002; (3): 252-63
- Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells. Prostate. 2002; (4): 225-30
- Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement. J Urol. 2001; (4): 1560-4
- Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer. Urology. 2001; (2 Suppl 1): 123-6
- Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res. 2001; (7): 2852-6
- SMAD3 represses androgen receptor-mediated transcription. Cancer Res. 2001; (5): 2112-8
- 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms. Endocrinology. 2000; (7): 2548-56
- Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells. J Urol. 2000; (3 Pt 1): 836-41
- Cultured stromal cells: an in vitro model of prostatic mesenchymal biology. Prostate. 2000; (2): 115-23
- Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med. 2000; (6): 703-6
- Altered growth regulation and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells. Anticancer Res. 1999 Sep-Oct; (5B): 3857-64
- Induction of androgen receptor by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in LNCaP human prostate cancer cells. Endocrinology. 1999; (3): 1205-12
- Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. J Urol. 1999; (6): 2192-9
- Vitamin D and prostate cancer risk. Eur Urol. 1999; (5-6): 392-4
- Defined medium for normal adult human prostatic stromal cells. In Vitro Cell Dev Biol Anim. 1998 Jul-Aug; (7): 555-60
- Basic FGF, EGF, and PDGF modify TGFbeta-induction of smooth muscle cell phenotype in human prostatic stromal cells. Prostate. 1998; (2): 125-34
- 1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent. Endocrinology. 1997; (8): 3290-8
- Human papillomavirus detection by polymerase chain reaction in benign and malignant prostate tissue is dependent on the primer set utilized. Urology. 1997; (1): 150-6
- Induction of smooth muscle cell phenotype in cultured human prostatic stromal cells. Exp Cell Res. 1997; (2): 208-15
- Loss of response to epidermal growth factor and retinoic acid accompanies the transformation of human prostatic epithelial cells to tumorigenicity with v-Ki-ras. Carcinogenesis. 1997; (8): 1643-50
- Parathyroid hormone-related protein is not an autocrine growth factor for normal prostatic epithelial cells. Prostate. 1997; (1): 47-52
- Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res. 1997; (19): 4200-4
- Recent advances in the development of animal and cell culture models for prostate cancer research A minireview. Urol Oncol. 1996 July - August; (4): 99
- The role of insulin-like growth factors in prostate biology. J Androl. 1996 Jan-Feb; (1): 2-4
- Cellular biology of prostatic growth factors. Prostate Suppl. 1996: 74-8
- KGF and EGF differentially regulate the phenotype of prostatic epithelial cells. Growth Regul. 1996; (1): 22-31
- Keratin 19 in the adult human prostate: tissue and cell culture studies. Cell Tissue Res. 1996; (1): 171-6
- Parathyroid hormone--related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells. Prostate. 1996; (1): 20-9
- Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts. J Urol. 1996; (2 Pt 1): 526-31
- Simian virus 40-, but not human papillomavirus-, transformation of prostatic epithelial cells results in loss of growth-inhibition by 1,25-dihydroxyvitamin D-3. Int J Oncol. 1996; (1): 41-7
- Suramin, hydrocortisone, and retinoic acid modify inhibitory effects of 1,25-dihydroxyvitamin D(3) on prostatic epithelial cells. Urol Oncol. 1995 Sep-Oct; (5): 188-94
- Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3. Endocrinology. 1995; (1): 20-6
- Keratinocyte growth factor: an androgen-regulated mediator of stromal-epithelial interactions in the prostate. World J Urol. 1995; (5): 312-7
- The insulin-like growth factor system in the prostate. World J Urol. 1995; (5): 306-11
- Vitamin D and prostate cancer. Adv Exp Med Biol. 1995: 53-63
- Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res. 1994; (3): 805-10
- Characterization of adult human prostatic epithelial-cells immortalized by polybrene-induced DNA transfection with a plasmid containing an origin-defective sv40-genome. Int J Oncol. 1994; (4): 821-30
- Keratin expression: a measure of phenotypic modulation of human prostatic epithelial cells by growth inhibitory factors. Cell Tissue Res. 1994; (1): 11-8
- Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA. Cancer Res. 1994; (21): 5579-83
- Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients. J Clin Endocrinol Metab. 1993; (4): 1031-5
- Oncogenes in prostate cancer. An update. Cancer. 1993; (3 Suppl): 1159-64
- Vitamin A regulates proliferation and differentiation of human prostatic epithelial cells. Prostate. 1993; (1): 69-78
- Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology. 1993; (5): 1952-60
- Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992; (4): 1046-53
- Culture of prostatic epithelial cells from ultrasound-guided needle biopsies. Prostate. 1991; (2): 141-7
- Cytostatic effects of suramin on prostate cancer cells cultured from primary tumors. J Urol. 1991; (3): 624-30
- In vitro proton spectroscopy of normal and abnormal prostate. Magn Reson Med. 1991; (2): 429-38
- Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. J Clin Endocrinol Metab. 1991; (2): 401-7
- Searching for suppressor genes in prostate cancer. Cancer Surv. 1991: 25-34
- Analysis of somatic cell hybrids derived from normal human prostatic epithelial cells fused with HeLa cells. Prostate. 1990; (2): 123-36
- Clonal growth of human prostatic epithelial cells is stimulated by fibroblasts. Prostate. 1989; (3): 251-63
- In vitro studies of human prostatic epithelial cells: attempts to identify distinguishing features of malignant cells. Growth Factors. 1989; (3): 237-50
- Clonal growth characteristics of adult human prostatic epithelial cells. In Vitro Cell Dev Biol. 1988; (6): 530-6
- Oncogene expression. Prog Clin Biol Res. 1987: 77-90
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