Nicholas Denko
Publications
- Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2007; (22): 9445-50
- HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006; (3): 187-97
- Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm? Int J Cancer. 2011; (5): 1001-8
- Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011; (4): 1311-4
- Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res. 2010; (1): 78-88
- The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS One. 2010; (3): e9633
- FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009; (5): 527-39
- Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One. 2009; (9): e7033
- Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clin Cancer Res. 2009; (23): 7170-4
- Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ. 2008; (10): 1572-81
- Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer. 2008; (9): 705-13
- Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Mol Cell Biol. 2008; (23): 7212-24
- Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2007; (1): 167-75
- Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 2007; (2): 284-9
- Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol Cancer Res. 2006; (2): 61-70
- Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res. 2005; (8): 3171-8
- Cellular reaction to hypoxia: sensing and responding to an adverse environment. Mutat Res. 2005; (1-2): 87-100
- Functional characterization of human proapoptotic molecules in yeast S. cerevisiae. FASEB J. 2005; (3): 464-6
- Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol. 2005; (11): 948-55
- Hypoxic gene expression and metastasis. Cancer Metastasis Rev. 2004 Aug-Dec; (3-4): 293-310
- Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Cancer Res. 2004; (7): 2552-60
- XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004; (17): 5943-7
- Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem. 2003; (8): 5744-9
- Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 2003; (37): 5907-14
- Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol. 2002; (6): 1834-43
- Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem. 2002; (42): 40112-7
- Genetic determinants that influence hypoxia-induced apoptosis. Novartis Found Symp. 2001: 115-28; discussion 128-32
- Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis. Cancer Res. 2001; (3): 795-8
- Candidate genes for the hypoxic tumor phenotype. Cancer Res. 2000; (4): 883-7
- Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res. 2000; (2): 480-7
- p53 checkpoint-defective cells are sensitive to X rays but not hypoxia. -. 2000; (258): 82-91
- p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Exp Cell Res. 2000; (1): 82-91
- A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Oncogene. 1999; (47): 6540-5
- Highly conserved RNA sequences that are sensors of environmental stress. Mol Cell Biol. 1998; (12): 7371-82
- Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res. 1997; (21): 4703-6
- Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2). Cancer Res. 1994; (20): 5273-9
- The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity. Cancer Res. 1991; (16): 4463-9
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