Helen M. Blau
Publications
- A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal. Integr Biol (Camb). 2012; (4): 360-7
- Redefining differentiation: Reshaping our ends. Nat Cell Biol. 2012; (6): 558
- DNA demethylation dynamics. Cell. 2011; (6): 866-72
- Re"evolutionary" regenerative medicine. JAMA. 2011; (1): 87-8
- Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature. 2010; (7284): 1042-7
- Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell. 2010; (7): 1059-71
- Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science. 2010; (5995): 1078-81
- Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 2010; (2): 198-213
- A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells. FASEB J. 2013; (3): 1107-13
- An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis. Proc Natl Acad Sci U S A. 2013; (5): 1911-6
- Protein-engineered biomaterials to generate human skeletal muscle mimics. Adv Healthc Mater. 2012; (6): 785-9
- Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. FASEB J. 2012; (6): 2486-97
- Engineering a stem cell house into a home. Stem Cell Res Ther. 2011; (1): 3
- MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res. 2011; (5): 798-810
- Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood. 2011; (16): 4226-33
- Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism. Proc Natl Acad Sci U S A. 2011; (45): 18412-7
- Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions. Nat Methods. 2010; (4): 307-9
- A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches. Differentiation. 2009 Sep-Oct; (2-3): 185-94
- Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional. FASEB J. 2009; (5): 1431-40
- Perturbation of single hematopoietic stem cell fates in artificial niches. Integr Biol (Camb). 2009; (1): 59-69
- Reprogramming to a muscle fate by fusion recapitulates differentiation. J Cell Sci. 2009; (Pt 7): 1045-53
- Cell therapies for muscular dystrophy. N Engl J Med. 2008; (13): 1403-5
- Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation. Nat Cell Biol. 2008; (5): 575-83
- Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology. 2008; (2): 706-18
- Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. J Cell Biol. 2008; (5): 1005-19
- Self-renewal and expansion of single transplanted muscle stem cells. Nature. 2008; (7221): 502-6
- A novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization. FASEB J. 2007; (14): 3827-34
- A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals. FASEB J. 2007; (14): 3819-26
- Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons. Proc Natl Acad Sci U S A. 2007; (11): 4395-400
- Anne McLaren (1927-2007). Differentiation. 2007; (10): 899-901
- In vivo optical bioluminescence imaging of collagen-supported cardiac cell grafts. J Heart Lung Transplant. 2007; (3): 273-80
- Increased host neuronal survival and motor function in BMT Parkinsonian mice: involvement of immunosuppression. J Comp Neurol. 2007; (6): 690-701
- Localization of vascular response to VEGF is not dependent on heparin binding. FASEB J. 2007; (9): 2074-85
- Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem. 2007; (36): 26450-9
- Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol. 2007; (10): 668-77
- Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron. 2007; (1): 25-38
- A brief history of RNAi: the silence of the genes. FASEB J. 2006; (9): 1293-9
- A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions. Proc Natl Acad Sci U S A. 2006; (50): 19063-8
- Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts. Circulation. 2006; (1 Suppl): I174-80
- Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts. Circulation. 2006; (1 Suppl): I167-73
- Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence. Nat Methods. 2006; (4): 295-301
- Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. FASEB J. 2006; (14): 2657-9
- Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat Cell Biol. 2005; (6): 633-6
- Bone marrow contribution to skeletal muscle: a physiological response to stress. Dev Biol. 2005; (2): 336-44
- Enzymatic detection of protein translocation. Nat Methods. 2005; (7): 521-7
- IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors. J Cell Biol. 2005; (3): 483-92
- Optimizing techniques for tracking transplanted stem cells in vivo. Stem Cells. 2005; (9): 1251-65
- Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Circulation. 2005; (11): 1431-8
- mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage. Differentiation. 2005; (6): 287-93
- Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis. Gene Ther. 2004; (3): 302-9
- Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. PNAS. 2004; (37): 13507-13512
- Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A. 2004; (37): 13507-12
- Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004; (4): 516-27
- Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nat Cell Biol. 2004; (9): 810-6
- Nuclear reprogramming: a key to stem cell function in regenerative medicine. Nature Cell Biology. 2004; (9): 810-816
- Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nat Genet. 2004; (2): 183-9
- Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genetics. 2004; (2): 183-9
- Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. PNAS. 2003; (4): 2088-93
- Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc Natl Acad Sci U S A. 2003; (4): 2088-93
- Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Mol Ther. 2003; (4): 441-9
- Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Br J Pharmacol. 2003; (4): 620-6
- Significant differences among skeletal muscles in the incorporation of bone marrow-derived cells. Dev Biol. 2003; (1): 64-74
- Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol. 2003; (11): 959-66
- Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nature Cell Biology. 2003; (11): 959 - 966
- Gene delivery to muscle. Curr Protoc Hum Genet. 2002: Unit13.4
- Myoblast-mediated gene transfer for therapeutic angiogenesis. Methods Enzymol. 2002: 145-57
- Protein-protein interactions monitored in mammalian cells via complementation of beta -lactamase enzyme fragments. Proc Natl Acad Sci U S A. 2002; (6): 3469-74
- RIP2, a checkpoint in myogenic differentiation. Mol Cell Biol. 2002; (16): 5879-86
- Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation. Cell Motil Cytoskeleton. 2002; (4): 177-86
- VEGF gene delivery for treatment of ischemic cardiovascular disease. Trends Cardiovasc Med. 2002; (3): 108-14
- In vivo monitoring of myoblast transplantation into rat myocardium. J Heart Lung Transplant. 2001; (2): 188-189
- Laminin-induced change in conformation of preexisting alpha7beta1 integrin signals secondary myofiber formation. Dev Biol. 2001; (1): 148-60
- Not the usual suspects: the unexpected sources of tissue regeneration. J Clin Invest. 2001; (11): 1355-6
- Purification of mouse primary myoblasts based on alpha 7 integrin expression. Exp Cell Res. 2001; (2): 212-20
- The evolving concept of a stem cell: entity or function? Cell. 2001; (7): 829-41
- A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. Annu Rev Pharmacol Toxicol. 2000: 295-317
- Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther. 2000; (1): 82-7
- Epidermal growth factor receptor dimerization monitored in live cells. Nat Biotechnol. 2000; (2): 218-22
- From marrow to brain: expression of neuronal phenotypes in adult mice. Science. 2000; (5497): 1775-9
- Interaction blues: protein interactions monitored in live mammalian cells by beta-galactosidase complementation. Trends Cell Biol. 2000; (3): 119-22
- Monitoring protein-protein interactions in live mammalian cells by beta-galactosidase complementation. Methods Enzymol. 2000: 231-51
- Neural cell adhesion molecule (NCAM) and myoblast fusion. Dev Biol. 2000; (1): 112-9
- Transcriptional control: rheostat converted to on/off switch. Mol Cell. 2000; (3): 723-8
- Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Res. 1999; (3): 179-92
- Plasticity of cell fate: insights from heterokaryons. Semin Cell Dev Biol. 1999; (3): 267-72
- Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc Natl Acad Sci U S A. 1999; (3): 797-9
- The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev Biol. 1999; (1): 16-28
- Graded transcriptional response to different concentrations of a single transactivator. Proc Natl Acad Sci U S A. 1998; (23): 13670-5
- Highly conserved RNA sequences that are sensors of environmental stress. Mol Cell Biol. 1998; (12): 7371-82
- Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Somat Cell Mol Genet. 1998; (5): 281-9
- Recent advances in inducible gene expression systems. Curr Opin Biotechnol. 1998; (5): 451-6
- Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nat Genet. 1998; (4): 389-93
- VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell. 1998; (5): 549-58
- Death of solid tumor cells induced by Fas ligand expressing primary myoblasts. Somat Cell Mol Genet. 1997; (4): 249-57
- Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J Cell Biol. 1997; (2): 331-6
- High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet. 1997; (3): 203-9
- Methods for myoblast transplantation. Methods Cell Biol. 1997: 261-72
- Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation. Proc Natl Acad Sci U S A. 1997; (16): 8405-10
- Defective myogenesis in NFB-s mutant associated with a saturable suppression of MYF5 activity. Somat Cell Mol Genet. 1996; (5): 349-61
- Gene expression and cell fusion analyzed by lacZ complementation in mammalian cells. Proc Natl Acad Sci U S A. 1996; (22): 12423-7
- Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse. Somat Cell Mol Genet. 1996; (5): 363-81
- Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. Proc Natl Acad Sci U S A. 1996; (11): 5185-90
- Spectrophotometric quantitation of tissue culture cell number in any medium. Biotechniques. 1996; (2): 260-2, 264, 266
- Gene therapy--a novel form of drug delivery. N Engl J Med. 1995; (18): 1204-7
- Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Somat Cell Mol Genet. 1995; (4): 233-40
- The fate of myoblasts following transplantation into mature muscle. Exp Cell Res. 1995; (2): 383-9
- Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception. J Cell Sci. 1994: 2361-71
- Membrane-bound neomycin phosphotransferase confers drug-resistance in mammalian cells: a marker for high-efficiency targeting of genes encoding secreted and cell-surface proteins. Somat Cell Mol Genet. 1994; (3): 153-62
- Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J Cell Biol. 1994; (6): 1275-87
- Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy. J Immunol. 1994; (10): 4798-805
- Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers. J Cell Biol. 1994; (6 Pt 2): 1923-32
- Evidence for myoblast-extrinsic regulation of slow myosin heavy chain expression during muscle fiber formation in embryonic development. J Cell Biol. 1993; (4): 795-810
- Genetic complementation reveals a novel regulatory role for 3' untranslated regions in growth and differentiation. Cell. 1993; (6): 903-17
- Myoblasts in pattern formation and gene therapy. Trends Genet. 1993; (8): 269-74
- Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle. Dev Biol. 1993; (1): 183-99
- Tumor suppression by RNA from the 3' untranslated region of alpha-tropomyosin. Cell. 1993; (6): 1107-17
- Beta-enolase is a marker of human myoblast heterogeneity prior to differentiation. Dev Biol. 1992; (2): 626-9
- Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector. Somat Cell Mol Genet. 1992; (2): 163-77
- Differentiation requires continuous active control. Annu Rev Biochem. 1992: 1213-30
- Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell. 1992; (4): 659-71
- Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Nature. 1992; (6368): 435-8
- Regulating the myogenic regulators. Symp Soc Exp Biol. 1992: 9-18
- Differentiation requires continuous regulation. J Cell Biol. 1991; (5): 781-3
- Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-gamma. Neurology. 1991; (7): 1128-32
- Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science. 1991; (5037): 1509-12
- Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: implications for cell and gene therapy. Somat Cell Mol Genet. 1990; (6): 557-65
- Cell lineage in vertebrate development. Curr Opin Cell Biol. 1990; (6): 981-5
- Effect of cell history on response to helix-loop-helix family of myogenic regulators. Nature. 1990; (6265): 454-8
- Localization of muscle gene products in nuclear domains: does this constitute a problem for myoblast therapy? Adv Exp Med Biol. 1990: 167-72
- Migration of myoblasts across basal lamina during skeletal muscle development. Nature. 1990; (6273): 350-3
- Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant. Cell. 1990; (3): 493-502
- Purification and proliferation of human myoblasts isolated with fluorescence activated cell sorting. Adv Exp Med Biol. 1990: 97-100
- Retroviral lineage markers for assessing myoblast fate in vivo. Adv Exp Med Biol. 1990: 201-3
- Steroids induce acetylcholine receptors on cultured human muscle: implications for myasthenia gravis. Proc Natl Acad Sci U S A. 1990; (20): 8100-4
- In vivo aging of human fibroblasts does not alter nuclear plasticity in heterokaryons. Somat Cell Mol Genet. 1989; (3): 191-202
- Localization of muscle gene products in nuclear domains. Nature. 1989; (6207): 570-3
- Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell. 1988; (4): 503-13
- Hierarchies of regulatory genes may specify mammalian development. Cell. 1988; (5): 673-4
- In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. J Cell Biol. 1988; (4): 1027-34
- Isolation of human myoblasts with the fluorescence-activated cell sorter. Exp Cell Res. 1988; (1): 252-65
- Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons. Genes Dev. 1988; (3): 330-40
- Tumor necrosis factor inhibits human myogenesis in vitro. Mol Cell Biol. 1988; (6): 2295-301
- Differential patterns of transcript accumulation during human myogenesis. Mol Cell Biol. 1987; (11): 4100-14
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