David B. Lewis

Publications

• Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a. Palin AC, Ramachandran V, Acharya S, Lewis DB. J Immunol. 2013; 190 (6): 2682-91
• Cross-reactive neutralizing antibody against pandemic 2009 H1N1 influenza a virus in intravenous immunoglobulin preparations. Hong DK, Tremoulet AH, Burns JC, Lewis DB. Pediatr Infect Dis J. 2011; 30 (1): 67-9
• Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID. Yu GP, Nadeau KC, Berk DR, de Saint Basile G, Lambert N, Knapnougel P, Roberts J, Kavanau K, Dunn E, Stiehm ER, Lewis DB, Umetsu DT, Puck JM, Cowan MJ. Pediatr Transplant. 2011; 15 (7): 733-41
• Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility. Lewis DB, Haines C, Ross D. J Perinatol. 2011: 31 Suppl 1 S72-81
• Adult-onset presentations of genetic immunodeficiencies: genes can throw slow curves. Nelson KS, Lewis DB. Curr Opin Infect Dis. 2010; 23 (4): 359-64
• Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses. O'Gorman WE, Sampath P, Simonds EF, Sikorski R, O'Malley M, Krutzik PO, Chen H, Panchanathan V, Chaudhri G, Karupiah G, Lewis DB, Thorne SH, Nolan GP. Cell Host Microbe. 2010; 8 (2): 174-85
• Cationic lipid/DNA complex-adjuvanted influenza A virus vaccination induces robust cross-protective immunity. Hong DK, Chang S, Botham CM, Giffon TD, Fairman J, Lewis DB. J Virol. 2010; 84 (24): 12691-702
• Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. de Beaucoudrey L, Samarina A, Bustamante J, Cobat A, Boisson-Dupuis S, Feinberg J, Al-Muhsen S, Jannière L, Rose Y, de Suremain M, Kong XF, Filipe-Santos O, Chapgier A, Picard C, Fischer A, Dogu F, Ikinciogullari A, Tanir G, Al-Hajjar S, Al-Jumaah S, Frayha HH, AlSum Z, Al-Ajaji S, Alangari A, Al-Ghonaium A, Adimi P, Mansouri D, Ben-Mustapha I, Yancoski J, Garty BZ, Rodriguez-Gallego C, Caragol I, Kutukculer N, Kumararatne DS, Patel S, Doffinger R, Exley A, Jeppsson O, Reichenbach J, Nadal D, Boyko Y, Pietrucha B, Anderson S, Levin M, Schandené L, Schepers K, Efira A, Mascart F, Matsuoka M, Sakai T, Siegrist CA, Frecerova K, Blüetters-Sawatzki R, Bernhöft J, Freihorst J, Baumann U, Richter D, Haerynck F, De Baets F, Novelli V, Lammas D, Vermylen C, Tuerlinckx D, Nieuwhof C, Pac M, Haas WH, Müller-Fleckenstein I, Fleckenstein B, Levy J, Raj R, Cohen AC, Lewis DB, Holland SM, Yang KD, Wang X, Wang X, Jiang L, Yang X, Zhu C, Xie Y, Lee PP, Chan KW, Chen TX, Castro G, Natera I, Codoceo A, King A, Bezrodnik L, Di Giovani D, Gaillard MI, de Moraes-Vasconcelos D, Grumach AS, da Silva Duarte AJ, Aldana R, Espinosa-Rosales FJ, Bejaoui M, Bousfiha AA, Baghdadi JE, Ozbek N, Aksu G, Keser M, Somer A, Hatipoglu N, Aydogmus C, Asilsoy S, Camcioglu Y, Gülle S, Ozgur TT, Ozen M, Oleastro M, Bernasconi A, Mamishi S, Parvaneh N, Rosenzweig S, Barbouche R, Pedraza S, Lau YL, Ehlayel MS, Fieschi C, Abel L, Sanal O, Casanova JL. Medicine (Baltimore). 2010; 89 (6): 381-402
• A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Matute JD, Arias AA, Wright NA, Wrobel I, Waterhouse CC, Li XJ, Marchal CC, Stull ND, Lewis DB, Steele M, Kellner JD, Yu W, Meroueh SO, Nauseef WM, Dinauer MC. Blood. 2009; 114 (15): 3309-15
• Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone) increases antibody response, cellular immunity, and antigenically drifted protection. Lay M, Callejo B, Chang S, Hong DK, Lewis DB, Carroll TD, Matzinger S, Fritts L, Miller CJ, Warner JF, Liang L, Fairman J. Vaccine. 2009; 27 (29): 3811-20
• Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells. Zheng J, Liu Y, Qin G, Chan PL, Mao H, Lam KT, Lewis DB, Lau YL, Tu W. J Immunol. 2009; 183 (6): 3742-50
• Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. Haines CJ, Giffon TD, Lu LS, Lu X, Tessier-Lavigne M, Ross DT, Lewis DB. J Exp Med. 2009; 206 (2): 275-85
• A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Bhui RD, Lewis DB, Nadeau KC. Ann Allergy Asthma Immunol. 2008; 100 (2): 169
• Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus. Potena L, Fearon WF, Sydow K, Holweg C, Luikart H, Chin C, Weisshaar D, Mocarski ES, Lewis DB, Valantine HA, Cooke JP. Transplantation. 2008; 85 (6): 827-33
• Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Tu W, Lau YL, Zheng J, Liu Y, Chan PL, Mao H, Dionis K, Schneider P, Lewis DB. Blood. 2008; 112 (6): 2554-62
• Focus on FOCIS: the continuing diagnostic challenge of autosomal recessive chronic granulomatous disease. Yu G, Hong DK, Dionis KY, Rae J, Heyworth PG, Curnutte JT, Lewis DB. Clin Immunol. 2008; 128 (2): 117-26
• Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency. Dvorak CC, Sandford A, Fong A, Cowan MJ, George TI, Lewis DB. J Pediatr Hematol Oncol. 2008; 30 (5): 396-400
• Humoral and cellular immune responses in children given annual immunization with trivalent inactivated influenza vaccine. Zeman AM, Holmes TH, Stamatis S, Tu W, He XS, Bouvier N, Kemble G, Greenberg HB, Lewis DB, Arvin AM, Dekker CL. Pediatr Infect Dis J. 2007; 26 (2): 107-15
• Influenza A virus elevates active cathepsin B in primary murine DC. Burster T, Giffon T, Dahl ME, Björck P, Bogyo M, Weber E, Mahmood K, Lewis DB, Mellins ED. Int Immunol. 2007; 19 (5): 645-55
• [Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome]. Potena L, Ferrara R, Mocarski ES, Lewis DB, Cooke JP, Grigioni F, Coccolo F, Magnani G, Fallani F, Magelli C, Valantine HA, Branzi A. G Ital Cardiol (Rome). 2007; 8 (2): 73-82
• Newborn immunology: relevance to the clinician. Lewis DB, Gern JE, Hill HR, Friedlander SL, La Pine TR, Lemanske RF, Stiehm ER. Curr Probl Pediatr Adolesc Health Care. 2006 May-Jun; 36 (5): 189-204
• Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Potena L, Holweg CT, Chin C, Luikart H, Weisshaar D, Narasimhan B, Fearon WF, Lewis DB, Cooke JP, Mocarski ES, Valantine HA. Transplantation. 2006; 82 (3): 398-405
• Avian flu to human influenza. Lewis DB, Annu Rev Med. 2006: 57 139-54
• Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines. He XS, Holmes TH, Zhang C, Mahmood K, Kemble GW, Lewis DB, Dekker CL, Greenberg HB, Arvin AM. J Virol. 2006; 80 (23): 11756-66
• Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus. Debes GF, Dahl ME, Mahiny AJ, Bonhagen K, Campbell DJ, Siegmund K, Erb KJ, Lewis DB, Kamradt T, Hamann A. J Immunol. 2006; 176 (1): 557-66
• Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB. J Immunol. 2006; 177 (5): 2770-4
• Impaired allogeneic activation and T-helper 1 differentiation of human cord blood naive CD4 T cells. Chen L, Cohen AC, Lewis DB. Biol Blood Marrow Transplant. 2006; 12 (2): 160-71
• T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. Tu W, Potena L, Stepick-Biek P, Liu L, Dionis KY, Luikart H, Fearon WF, Holmes TH, Chin C, Cooke JP, Valantine HA, Mocarski ES, Lewis DB. Circulation. 2006; 114 (15): 1608-15
• Transient deficiencies of T-cell-mediated immunity in the neonate. Randolph DA, Lewis DB. Adv Exp Med Biol. 2006: 582 55-69
• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, Gyarmati D, Aye T, Campbell DJ, Ziegler SF. Nat Immunol. 2005; 6 (10): 1047-53
• Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. Chen SF, Tu WW, Sharp MA, Tongson EC, He XS, Greenberg HB, Holmes TH, Wang Z, Kemble G, Manganello AM, Adler SP, Dekker CL, Lewis DB, Arvin AM. J Infect Dis. 2004; 189 (9): 1619-27
• Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children. Tu W, Chen S, Sharp M, Dekker C, Manganello AM, Tongson EC, Maecker HT, Holmes TH, Wang Z, Kemble G, Adler S, Arvin A, Lewis DB. J Immunol. 2004; 172 (5): 3260-7
• Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Dahl ME, Dabbagh K, Liggitt D, Kim S, Lewis DB. Nat Immunol. 2004; 5 (3): 337-43
• Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation. Jullien P, Cron RQ, Dabbagh K, Cleary A, Chen L, Tran P, Stepick-Biek P, Lewis DB. Int Immunol. 2003; 15 (12): 1461-72
• Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. Cleary AM, Tu W, Enright A, Giffon T, Dewaal-Malefyt R, Gutierrez K, Lewis DB. J Immunol. 2003; 170 (1): 597-603
• Toll-like receptors and T-helper-1/T-helper-2 responses. Dabbagh K, Lewis DB. Curr Opin Infect Dis. 2003; 16 (3): 199-204
• A T cell-specific enhancer of the human CD40 ligand gene. Schubert LA, Cron RQ, Cleary AM, Brunner M, Song A, Lu LS, Jullien P, Krensky AM, Lewis DB. J Biol Chem. 2002; 277 (9): 7386-95
• Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Lewis DB, Curr Opin Immunol. 2002; 14 (5): 644-51
• Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors. Dunn HS, Haney DJ, Ghanekar SA, Stepick-Biek P, Lewis DB, Maecker HT. J Infect Dis. 2002; 186 (1): 15-22
• Simple febrile seizures: do polymorphisms of the interleukin 1 gene cluster simplify our understanding? Lewis DB, Arch Pediatr Adolesc Med. 2002; 156 (6): 529-30
• Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. Dabbagh K, Dahl ME, Stepick-Biek P, Lewis DB. J Immunol. 2002; 168 (9): 4524-30
• Group A streptococcal meningitis: report of a case and review of literature since 1976. Shetty AK, Frankel LR, Maldonado Y, Falco DA, Lewis DB. Pediatr Emerg Care. 2001; 17 (6): 430-4
• Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. Cron RQ, Zhou B, Brunvand MW, Lewis DB. Genes Immun. 2001; 2 (8): 464-8
• An immunosuppressive and anti-inflammatory HLA class I-derived peptide binds vascular cell adhesion molecule-1. Ling X, Tamaki T, Xiao Y, Kamangar S, Clayberger C, Lewis DB, Krensky AM. Transplantation. 2000; 70 (4): 662-7
• Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Nature. 2000; 403 (6769): 503-11
• Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI. Dabbagh K, Xiao Y, Smith C, Stepick-Biek P, Kim SG, Lamm WJ, Liggitt DH, Lewis DB. J Immunol. 2000; 165 (6): 3418-22
• NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells. Cron RQ, Bartz SR, Clausell A, Bort SJ, Klebanoff SJ, Lewis DB. Clin Immunol. 2000; 94 (3): 179-91
• Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. Tsitoura DC, Kim S, Dabbagh K, Berry G, Lewis DB, Umetsu DT. J Immunol. 2000; 165 (6): 3484-91
• Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease. Zeng D, Lewis D, Dejbakhsh-Jones S, Lan F, García-Ojeda M, Sibley R, Strober S. J Exp Med. 1999; 189 (7): 1073-81
• T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells. Cron RQ, Bort SJ, Wang Y, Brunvand MW, Lewis DB. J Immunol. 1999; 162 (2): 860-70
• Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes. Cron RQ, Schubert LA, Lewis DB, Hughes CC. J Immunol Methods. 1997; 205 (2): 145-50
• Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Zhang Y, Lamm WJ, Albert RK, Chi EY, Henderson WR, Lewis DB. Am J Respir Crit Care Med. 1997; 155 (2): 661-9
• Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. Zhang Y, Rogers KH, Lewis DB. J Exp Med. 1996; 184 (4): 1507-12
• Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Dolganov G, Bort S, Lovett M, Burr J, Schubert L, Short D, McGurn M, Gibson C, Lewis DB. Blood. 1996; 87 (8): 3316-26
• The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson WR, Lewis DB, Albert RK, Zhang Y, Lamm WJ, Chiang GK, Jones F, Eriksen P, Tien YT, Jonas M, Chi EY. J Exp Med. 1996; 184 (4): 1483-94
• Diminished expression of CD40 ligand by activated neonatal T cells. Nonoyama S, Penix LA, Edwards CP, Lewis DB, Ito S, Aruffo A, Wilson CB, Ochs HD. J Clin Invest. 1995; 95 (1): 66-75
• Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells. Melvin AJ, McGurn ME, Bort SJ, Gibson C, Lewis DB. Eur J Immunol. 1995; 25 (2): 426-30
• The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. Schubert LA, King G, Cron RQ, Lewis DB, Aruffo A, Hollenbaugh D. J Biol Chem. 1995; 270 (50): 29624-7
• Lymphokine regulation and the role of abnormal regulation in immunodeficiency. Wilson CB, Penix L, Melvin A, Lewis DB. Clin Immunol Immunopathol. 1993; 67 (3 Pt 2): S25-32
• Osteoporosis induced in mice by overproduction of interleukin 4. Lewis DB, Liggitt HD, Effmann EL, Motley ST, Teitelbaum SL, Jepsen KJ, Goldstein SA, Bonadio J, Carpenter J, Perlmutter RM. Proc Natl Acad Sci U S A. 1993; 90 (24): 11618-22
• Ontogeny of T lymphocyte function in the neonate. Wilson CB, Penix L, Weaver WM, Melvin A, Lewis DB. Am J Reprod Immunol. 1992 Oct-Dec; 28 (3-4): 132-5
• Clinical and microbiologic characteristics of cutaneous infection with Yersinia enterocolitica. Krogstad P, Mendelman PM, Miller VL, Clausen C, Abbott S, Weagant S, Wilson CL, Lewis DB. J Infect Dis. 1992; 165 (4): 740-3
• Decreased granulocyte-macrophage colony-stimulating factor production by human neonatal blood mononuclear cells and T cells. English BK, Hammond WP, Lewis DB, Brown CB, Wilson CB. Pediatr Res. 1992; 31 (3): 211-6
• Hawkinsinuria in two families. Borden M, Holm J, Leslie J, Sweetman L, Nyhan WL, Fleisher L, Nadler H, Lewis D, Scott CR. Am J Med Genet. 1992; 44 (1): 52-6
• Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells. Lewis DB, Yu CC, Meyer J, English BK, Kahn SJ, Wilson CB. J Clin Invest. 1991; 87 (1): 194-202
• Developmental regulation of lck gene expression in T lymphocytes. Wildin RS, Garvin AM, Pawar S, Lewis DB, Abraham KM, Forbush KA, Ziegler SF, Allen JM, Perlmutter RM. J Exp Med. 1991; 173 (2): 383-93
• Interleukin 4 expressed in situ selectively alters thymocyte development. Lewis DB, Yu CC, Forbush KA, Carpenter J, Sato TA, Grossman A, Liggitt DH, Perlmutter RM. J Exp Med. 1991; 173 (1): 89-100
• T cell development in the fetus and neonate. Wilson CB, Lewis DB, English BK. Adv Exp Med Biol. 1991: 310 17-27
• Basis and implications of selectively diminished cytokine production in neonatal susceptibility to infection. Wilson CB, Lewis DB. Rev Infect Dis. 1990 May-Jun: 12 Suppl 4 S410-20
• Gamma-interferon: an immunoregulatory lymphokine with immunotherapeutic potential. Lewis DB, Wilson CB. Pediatr Infect Dis J. 1990; 9 (9): 642-51
• Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. Vercelli D, Jabara HH, Cunningham-Rundles C, Abrams JS, Lewis DB, Meyer J, Schneider LC, Leung DY, Geha RS. J Clin Invest. 1990; 85 (5): 1666-71
• Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck). Marth JD, Lewis DB, Cooke MP, Mellins ED, Gearn ME, Samelson LE, Wilson CB, Miller AD, Perlmutter RM. J Immunol. 1989; 142 (7): 2430-7
• Restricted production of interleukin 4 by activated human T cells. Lewis DB, Prickett KS, Larsen A, Grabstein K, Weaver M, Wilson CB. Proc Natl Acad Sci U S A. 1988; 85 (24): 9743-7
• Structure and expression of lck transcripts in human lymphoid cells. Perlmutter RM, Marth JD, Lewis DB, Peet R, Ziegler SF, Wilson CB. J Cell Biochem. 1988; 38 (2): 117-26
• Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Ziegler SF, Marth JD, Lewis DB, Perlmutter RM. Mol Cell Biol. 1987; 7 (6): 2276-85
• Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. Marth JD, Lewis DB, Wilson CB, Gearn ME, Krebs EG, Perlmutter RM. EMBO J. 1987; 6 (9): 2727-34
• Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. Wilson CB, Westall J, Johnston L, Lewis DB, Dower SK, Alpert AR. J Clin Invest. 1986; 77 (3): 860-7
• Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation. Lewis DB, Larsen A, Wilson CB. J Exp Med. 1986; 163 (4): 1018-23