Gerald Crabtree
Publications
- From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet. 2013; (5): 347-59
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013
- Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 2013; (1): 71-85
- Dynamics and memory of heterochromatin in living cells. Cell. 2012; (7): 1447-60
- Dynamics of inherently bounded histone modification domains. Proc Natl Acad Sci U S A. 2012; (33): 13296-301
- Engineering the ABA plant stress pathway for regulation of induced proximity. Sci Signal. 2011; (164): rs2
- MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 2011; (7359): 228-31
- Chromatin remodelling during development. Nature. 2010; (7280): 474-84
- An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A. 2009; (13): 5187-91
- An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A. 2009; (13): 5181-6
- MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature. 2009; (7255): 642-6
- Understanding the words of chromatin regulation. Cell. 2009; (2): 200-6
- ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. Cell Stem Cell. 2013; (2): 193-203
- MicroRNAs: regulators of neuronal fate. Curr Opin Cell Biol. 2013; (2): 215-21
- Our fragile intellect. Part I. Trends Genet. 2013; (1): 1-3
- Our fragile intellect. Part II. Trends Genet. 2013; (1): 3-5
- Our fragile intellect: response to Dr Mitchell. Trends Genet. 2013; (2): 60-2
- Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell. 2012; (1): 21-34
- Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation. J Biomol Screen. 2012; (9): 1221-30
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 2011; (3): 396-420
- esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol. 2011; (8): 903-13
- ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol. 2009; (2): 120-6
- Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009; (5914): 651-4
- SnapShot: Ca2+-calcineurin-NFAT signaling. Cell. 2009; (1): 210, 210.e1
- Selective role of calcineurin in haematopoiesis and lymphopoiesis. EMBO Rep. 2008; (11): 1141-8
- An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007; (2): 201-15
- Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature. 2007; (7170): 731-5
- Cell signaling. Nuclear actin as choreographer of cell morphology and transcription. Science. 2007; (5832): 1710-1
- Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature. 2007; (7131): 79-82
- Engineering small molecule specificity in nearly identical cellular environments. Bioorg Med Chem Lett. 2007; (10): 2703-5
- Exploiting protein destruction for constructive use. Proc Natl Acad Sci U S A. 2007; (28): 11511-2
- NFAT signaling and the invention of vertebrates. Trends Cell Biol. 2007; (6): 251-60
- Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron. 2007; (1): 94-108
- Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007; (12): 3023-8
- Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem. 2007; (10): 1162-9
- A Foxy tango with NFAT. Nat Immunol. 2006; (9): 906-8
- Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006; (6): 771-82
- Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006; (7109): 345-9
- Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest. 2006; (10): 2597-609
- Lymphocyte calcium signaling from membrane to nucleus. Nat Immunol. 2006; (1): 25-32
- NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006; (7093): 595-600
- Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol. 2006; (1): 99-107
- Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol. 2006; (20): 7372-87
- The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity. 2006; (2): 141-52
- 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochem Soc Trans. 2005; (Pt 4): 543-7
- Immunology. Decoding calcium signaling. Science. 2005; (5706): 56-7
- A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004; (5): 649-63
- Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004; (3): 255-66
- Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest. 2004; (7): 1051-8
- Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science. 2004; (5697): 865-9
- Calcium signalling in lymphocytes. Curr Opin Immunol. 2003; (3): 299-307
- Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell. 2003; (6): 1615-24
- Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003; (5): 657-70
- Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity. 2003; (2): 169-82
- Sonographic staging of the developmental status of mouse embryos in utero. Genesis. 2003; (1): 7-11
- Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A. 2002; (18): 11796-801
- Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene. J Biol Chem. 2002; (32): 28884-91
- Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002; (19): 2509-17
- NFAT signaling: choreographing the social lives of cells. Cell. 2002: S67-79
- Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem. 2002: 755-81
- Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci U S A. 2002; (5): 2824-9
- Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature. 2002; (6894): 195-9
- Calcineurin inhibitors and the generalization of the presenting protein strategy. Adv Protein Chem. 2001: 253-91
- Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001; (4): 2313-6
- Cell signaling can direct either binary or graded transcriptional responses. EMBO J. 2001; (12): 3167-76
- Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proc Natl Acad Sci U S A. 2001; (10): 5740-5
- Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling. Curr Opin Immunol. 2001; (3): 346-50
- NFAT signaling in vertebrate development. Curr Opin Genet Dev. 2001; (5): 505-12
- Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001; (7): 863-75
- Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function. J Biol Chem. 2000; (33): 25381-90
- Perspectives: signal transduction. Inositol phosphates in the nucleus. Science. 2000; (5460): 1937-9
- Searching for a function for nuclear actin. Trends Cell Biol. 2000; (3): 92-7
- The cytoskeleton in lymphocyte signaling. Adv Immunol. 2000: 89-114
- The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc Natl Acad Sci U S A. 2000; (18): 10150-5
- Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces. Proc Natl Acad Sci U S A. 1999; (5): 1953-8
- Continuous and widespread roles for the Swi-Snf complex in transcription. EMBO J. 1999; (8): 2254-64
- Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell. 1999; (5): 611-4
- L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 1999; (6754): 703-8
- Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. Cold Spring Harb Symp Quant Biol. 1999: 505-16
- The Actin Cytoskeleton and Lymphocyte Activation Cell --. 1999
- Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci U S A. 1998; (2): 492-8
- Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol. 1998; (10): 563-72
- Dimerization as a regulatory mechanism in signal transduction. Annu Rev Immunol. 1998: 569-92
- Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. Genomics. 1998; (1): 140-3
- Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998; (5): 625-36
- Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase. Mol Biol Cell. 1997; (12): 2519-37
- Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 1997; (4): 419-28
- Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. J Invest Dermatol. 1997; (2): 215-9
- Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science. 1997; (5308): 1930-4
- Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 1997; (7): 824-34
- Protein acetylation: more than chromatin modification to regulate transcription. Chem Biol. 1997; (12): 885-8
- Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J. 1997; (18): 5618-28
- Rapid targeting of nuclear proteins to the cytoplasm. Curr Biol. 1997; (9): 638-44
- Redundant expression but selective utilization of nuclear factor of activated T cells family members. J Immunol. 1997; (6): 2735-40
- The transcriptional paradox: octamer factors and B and T cells. Science. 1997; (5323): 193-4
- Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature. 1996; (6594): 822-6
- Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996; (17): 2117-30
- Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr Biol. 1996; (7): 839-47
- Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996; (19): 5370-82
- Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature. 1996; (6603): 837-40
- Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. J Biol Chem. 1996; (49): 31666-9
- The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol. 1996; (3 Pt 2): S40-5
- Three-part inventions: intracellular signaling and induced proximity. Trends Biochem Sci. 1996; (11): 418-22
- A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc Natl Acad Sci U S A. 1995; (21): 9805-9
- Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels. J Cell Biol. 1995; (3): 655-67
- Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. 1995; (3-4): 185-91
- Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Immunity. 1995; (2): 239-50
- NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995; (34): 19898-907
- Signal transduction in T lymphocytes using a conditional allele of Sos. Proc Natl Acad Sci U S A. 1995; (21): 9810-4
- Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Adv Exp Med Biol. 1994: 167-73
- Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature. 1994; (6506): 570-3
- Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. J Biol Chem. 1994; (42): 26431-7
- NF-AT components define a family of transcription factors targeted in T-cell activation. Nature. 1994; (6480): 497-502
- Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem. 1994: 1045-83
- Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proc Natl Acad Sci U S A. 1994; (20): 9203-7
- BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature. 1993; (6451): 170-4
- Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann N Y Acad Sci. 1993: 20-30
- Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. J Biol Chem. 1993; (4): 2917-23
- Controlling signal transduction with synthetic ligands. Science. 1993; (5136): 1019-24
- Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murine chromosomes 10. Genomics. 1993; (1): 292-5
- Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993; (8): 4760-9
- Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev. 1993; (2): 188-96
- Primary extrauterine endometrial stromal neoplasms: a clinicopathologic study of 20 cases and a review of the literature. Int J Gynecol Pathol. 1993; (4): 282-96
- Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition. Ann N Y Acad Sci. 1993: 31-7
- Regulation of the HNF-1 homeodomain proteins by DCoH. Curr Opin Genet Dev. 1993; (2): 246-53
- A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 1992; (6359): 457-61
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 1992; (6380): 695-7
- In vitro transcription faithfully reflecting T-cell activation requirements. J Biol Chem. 1992; (1): 399-406
- Negative regulation of interleukin 2 transcription by the glucocorticoid receptor. J Exp Med. 1992; (5): 1235-45
- Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. 1992; (6381): 70-3
- Regulation of the interleukin-2 gene. Chem Immunol. 1992: 266-98
- Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. Science. 1991; (5031): 558-62
- Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science. 1991; (5039): 1762-7
- HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev. 1991; (6): 1042-56
- HNF-1, a member of a novel class of dimerizing homeodomain proteins. J Biol Chem. 1991; (2): 677-80
- Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. EMBO J. 1991; (8): 2231-6
- Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991; (6338): 803-7
- Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes. Transplant Proc. 1991; (6): 2845
- Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J Biol Chem. 1990; (26): 15788-95
- HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes Dev. 1990; (3): 372-9
- Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc Natl Acad Sci U S A. 1990; (24): 9838-42
- Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev. 1990; (10): 1823-34
- T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med. 1990; (8): 510-7
- The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J. 1990; (13): 4425-33
- Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol. 1990: 421-52
- Contingent genetic regulatory events in T lymphocyte activation. Science. 1989; (4889): 355-61
- Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science. 1989; (4937): 1617-20
- The role of HNF-1 in liver-specific gene expression. Ann N Y Acad Sci. 1989: 272-8, discussion 279
- A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1. EMBO J. 1988; (8): 2485-93
- Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol. 1988; (4): 1715-24
- Identification of a putative regulator of early T cell activation genes. Science. 1988; (4862): 202-5
- Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci U S A. 1988; (21): 7937-41
- Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the gamma-fibrinogen promoter. Mol Cell Biol. 1988; (6): 2628-37
- Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science. 1987; (4827): 688-92
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