Mark M. Davis
Publications
- How the immune system talks to itself: the varied role of synapses. Immunol Rev. 2013; (1): 65-79
- Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med. 2013; (171): 171ra19
- Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity. 2013; (2): 373-83
- Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity. 2012; (1): 142-52
- High-throughput, high-fidelity HLA genotyping with deep sequencing. Proc Natl Acad Sci U S A. 2012; (22): 8676-81
- Immunology taught by humans. Sci Transl Med. 2012; (117): 117fs2
- Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. Nat Immunol. 2012; (7): 674-80
- Pluripotent stem cells: immune to the immune system? Sci Transl Med. 2012; (164): 164ps25
- Significance analysis of xMap cytokine bead arrays. Proc Natl Acad Sci U S A. 2012; (8): 2848-53
- γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity. 2012; (3): 524-34
- CD4+ T-cell synapses involve multiple distinct stages. Proc Natl Acad Sci U S A. 2011; (41): 17099-104
- Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis. Nat Rev Immunol. 2011; (8): 551-8
- Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest. 2011; (8): 3109-19
- Plasmablast-derived polyclonal antibody response after influenza vaccination. J Immunol Methods. 2011; (1-2): 67-75
- Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy. Methods Mol Biol. 2011: 169-82
- Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell. 2011; (3): 309-17
- Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). J Immunol. 2011; (10): 5823-32
- T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells. Proc Natl Acad Sci U S A. 2011; (4): 1549-54
- Transplantomics and biomarkers in organ transplantation: a report from the first international conference. Transplantation. 2011; (4): 379-82
- Cell type-specific gene expression differences in complex tissues. Nat Methods. 2010; (4): 287-9
- Functional development of the T cell receptor for antigen. Prog Mol Biol Transl Sci. 2010: 65-100
- Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med. 2010; (6): 1223-34
- TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol. 2010; (1): 90-6
- TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature. 2010; (7283): 963-7
- An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol. 2009; (11): 1162-9
- Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A. 2009; (10): 3970-5
- Simultaneous detection of many T-cell specificities using combinatorial tetramer staining. Nat Methods. 2009; (7): 497-9
- Towards a cytokine-cell interaction knowledgebase of the adaptive immune system. Pac Symp Biocomput. 2009: 439-50
- Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A. 2008; (35): 12991-6
- Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity. 2008; (5): 734-45
- The safety on the TCR trigger. Cell. 2008; (4): 594-6
- Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity. 2008; (1): 90-100
- Blimp-1 over Budapest. Nat Immunol. 2007; (5): 445-7
- Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Immunity. 2007; (3): 357-69
- Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity. 2007; (1): 76-88
- Structural insight into pre-B cell receptor function. Science. 2007; (5822): 291-4
- T cells as a self-referential, sensory organ. Annu Rev Immunol. 2007: 681-95
- The alphabeta T cell repertoire comes into focus. Immunity. 2007; (2): 179-80
- miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 2007; (1): 147-61
- Deconstructing the form and function of the TCR/CD3 complex. Immunity. 2006; (2): 133-9
- Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol. 2006; (1): 28-34
- Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci U S A. 2006; (50): 18992-7
- T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol. 2006; (3): 247-55
- A hybrid machine-learning approach for segmentation of protein localization data. Bioinformatics. 2005; (19): 3778-86
- Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 2005; (7030): 238-43
- Cellular immunotherapy: antigen recognition is just the beginning. Springer Semin Immunopathol. 2005; (1): 119-27
- Deformable modeling for improved calculation of molecular velocities from single-particle tracking. Proc IEEE Comput Syst Bioinform Conf. 2005: 208-11
- How T cells 'see' antigen. Nat Immunol. 2005; (3): 239-45
- Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PLoS Med. 2005; (10): e265
- Quantitative imaging of lymphocyte membrane protein reorganization and signaling. Biophys J. 2005; (1): 579-89
- CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol. 2004; (8): 791-9
- Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol. 2004; (9): 5427-40
- Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells. Proc Natl Acad Sci U S A. 2004; (39): 14204-9
- T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol. 2004; (5): 524-30
- T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol. 2004; (4): 579-90
- The evolutionary and structural 'logic' of antigen receptor diversity. Semin Immunol. 2004; (4): 239-43
- Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol. 2003; (8): 749-55
- Detection and characterization of cellular immune responses using peptide-MHC microarrays. PLoS Biol. 2003; (3): E65
- Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem. 2003: 717-42
- Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell. 2003; (6): 1367-78
- Linking molecular and cellular events in T-cell activation and synapse formation. Semin Immunol. 2003; (6): 307-15
- T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol. 2003; (12): 973-83
- A blood-borne antigen induces rapid T-B cell contact: a potential mechanism for tolerance induction. Immunology. 2002; (4): 420-5
- A new trigger for T cells. Cell. 2002; (3): 285-7
- CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J Exp Med. 2002; (4): 481-92
- Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol. 2002; (1): 42-7
- Direct observation of ligand recognition by T cells. Nature. 2002; (6909): 845-9
- Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002; (6): 809-22
- Identification of Epstein-Barr virus-specific CD8+ T lymphocytes in the circulation of pediatric transplant recipients. Transplantation. 2002; (4): 501-10
- Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity. 2002; (4): 595-606
- Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A. 2002; (23): 15024-9
- Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc Natl Acad Sci U S A. 2002; (14): 9374-9
- Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature. 2002; (6897): 552-6
- A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity. 2001; (3): 243-52
- A kinetic window shapes the T cell receptor repertoire in the thymus Immunity. 2001
- Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci U S A. 2001; (15): 8809-14
- Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile. Proc Natl Acad Sci U S A. 2001; (18): 10261-6
- Direct functional analysis of epitope-specific CD8+ T cells in peripheral blood. Viral Immunol. 2001; (1): 59-69
- Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J Immunol. 2000; (11): 5626-34
- Differential Clustering of CD4 and CD3z during T Cell Recognition Science. 2000
- Differential clustering of CD4 and CD3zeta during T cell recognition. Science. 2000; (5483): 1349-52
- Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity. 2000; (1): 37-45
- How to ask questions (in 10 easy steps) Curr Biol. 2000; (21): R771
- Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry. 2000; (5): 1048-58
- The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc Natl Acad Sci U S A. 2000; (18): 10150-5
- Thirty-six views of T-cell recognition. Philos Trans R Soc Lond B Biol Sci. 2000; (1400): 1071-6
- A T cell receptor-specific blockade of positive selection. J Exp Med. 1999; (1): 13-24
- A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity. 1999; (4): 485-92
- Catalysis of peptide dissociation from class II MHC-peptide complexes. Proc Natl Acad Sci U S A. 1999; (12): 6581-6
- Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med. 1999; (6): 677-85
- Conformational isomers of a class II MHC-peptide complex in solution. J Mol Biol. 1999; (1): 207-18
- Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol. 1999; (3): 1780-8
- Negative selection of T cells occurs throughout thymic development. J Immunol. 1999; (2): 689-98
- Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci U S A. 1999; (10): 5692-7
- Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning. Proc Natl Acad Sci U S A. 1999; (20): 11446-51
- Visualizing T-cell recognition. Cold Spring Harb Symp Quant Biol. 1999: 243-51
- Visualizing lymphocyte recognition. Immunol Cell Biol. 1999; (2): 186-7
- A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science. 1998; (5397): 2266-9
- Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J Exp Med. 1998; (3): 515-25
- Formation of a highly peptide-receptive state of class II MHC. Immunity. 1998; (5): 699-709
- Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity. 1998; (6): 667-73
- Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity. 1998; (4): 459-66
- Kinetic isomers of a class II MHC-peptide complex. Biochemistry. 1998; (50): 17371-80
- Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol. 1998: 523-44
- Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc Natl Acad Sci U S A. 1998; (11): 6302-7
- A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997; (2): 255-71
- CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity. 1997; (3): 379-85
- Kinetics and extent of T cell activation as measured with the calcium signal. J Exp Med. 1997; (10): 1815-25
- Ligand-specific oligomerization of T-cell receptor molecules. Nature. 1997; (6633): 617-20
- Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins. Proc Natl Acad Sci U S A. 1997; (6): 2495-500
- T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure. Ciba Found Symp. 1997: 94-100; discussion 100-4
- A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 1996; (1): 53-61
- Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity. 1996; (2): 125-35
- Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J Exp Med. 1996; (2): 777-82
- Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced. J Exp Med. 1996; (1): 119-26
- Evolving catalysts in real time. Science. 1996; (5252): 1078-9
- Kinetic discrimination in T-cell activation. Proc Natl Acad Sci U S A. 1996; (4): 1401-5
- Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996; (5284): 94-6
- Technophilia. Curr Opin Immunol. 1996; (2): 255-6
- Antigen-specific development of primary and memory T cells in vivo. Science. 1995; (5207): 106-11
- CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature. 1995; (6536): 181-4
- Issues concerning the nature of antigen recognition by alpha beta and gamma delta T-cell receptors. Immunol Today. 1995; (7): 316-8
- T-cell receptor V-region usage and antigen specificity. The cytochrome c model system. Ann N Y Acad Sci. 1995: 1-11
- T-cell recognition of antigen. A process controlled by transient intermolecular interactions. Ann N Y Acad Sci. 1995: 62-9
- Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell. 1994; (2): 297-306
- CDR3 length in antigen-specific immune receptors. J Exp Med. 1994; (1): 323-8
- Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc Natl Acad Sci U S A. 1994; (26): 12862-6
- Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med. 1994; (5): 1539-49
- The nature of major histocompatibility complex recognition by gamma delta T cells. Cell. 1994; (1): 29-37
- Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J Immunol. 1994; (8): 3946-57
- Activation and differentiation requirements of primary T cells in vitro. Proc Natl Acad Sci U S A. 1993; (19): 8987-91
- Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli. Proc Natl Acad Sci U S A. 1993; (21): 10330-4
- How alpha beta T-cell receptors 'see' peptide/MHC complexes. Immunol Today. 1993; (12): 597-602
- T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J Exp Med. 1993; (2): 713-22
- Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes. Curr Opin Immunol. 1993; (1): 45-9
- Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity. J Immunol. 1993; (6): 2281-94
- pH affects both the mechanism and the specificity of peptide binding to a class II major histocompatibility complex molecule. Biochemistry. 1993; (44): 11761-8
- Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 1992; (6357): 224-30
- Molecular components of T-cell recognition. Annu Rev Immunol. 1992: 835-73
- pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule. EMBO J. 1992; (8): 2829-39
- A gamma/delta cell receptor heterodimer induces the expression of CD4 and CD8 in thymocytes. J Exp Med. 1991; (1): 293-6
- Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH. J Exp Med. 1991; (1): 219-28
- Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion. Int Immunol. 1991; (4): 385-93
- Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Eur J Immunol. 1991; (9): 2111-9
- Low affinity interaction of peptide-MHC complexes with T cell receptors. Science. 1991; (5039): 1788-91
- Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science. 1990; (4969): 677-9
- T cell receptor gene diversity and selection. Annu Rev Biochem. 1990: 475-96
- T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med. 1990; (8): 510-7
- The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell. 1990; (6): 1043-53
- A model for T cell receptor and MHC/peptide interaction. Adv Exp Med Biol. 1989: 13-6
- A possible basis for major histocompatibility complex-restricted T-cell recognition. Philos Trans R Soc Lond B Biol Sci. 1989; (1217): 521-4
- Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 1989; (6): 1035-46
- Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature. 1989; (6234): 559-62
- Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain. Science. 1989; (4888): 217-20
- T-cell development in T cell receptor alphabeta transgenic mice. Semin Immunol. 1989; (2): 105-16
- TCR recognition and selection in vivo. Cold Spring Harb Symp Quant Biol. 1989: 119-28
- The XLR gene product defines a novel set of proteins stabilized in the nucleus by zinc ions. J Cell Biol. 1989; (3): 779-87
- The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes. Nucleic Acids Res. 1989; (23): 9871-88
- A human T cell-specific molecule is a member of a new gene family. J Immunol. 1988; (3): 1018-25
- Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol Cell Biol. 1988; (12): 5459-69
- Molecular genetics of T-cell antigen receptors. Hosp Pract (Off Ed). 1988; (5): 157-64, 169-70
- T cell receptor beta-chain genes in BW5147 and other AKR tumors. Deletion order of murine V beta gene segments and possible 5' regulatory regions. J Immunol. 1988; (5): 1665-75
- T-cell antigen receptor genes and T-cell recognition. Nature. 1988; (6181): 395-402
- The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes. Nature. 1988; (6157): 627-31
- The in vitro translation product of the murine lambda 5 gene contains a functional signal peptide. Mol Immunol. 1988; (8): 687-93
- Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region. Proc Natl Acad Sci U S A. 1988; (21): 8161-5
- T-cell receptor delta gene rearrangements in early thymocytes. Nature. 1987 Dec 24-31; (6150): 722-7
- Identification and sequence of a fourth human T cell antigen receptor chain. Nature. 1987 Dec 10-16; (6148): 569-72
- Organization of the T-cell antigen-receptor beta-chain locus in mice. Proc Natl Acad Sci U S A. 1987; (21): 7639-43
- Rearrangement and expression of T cell receptor genes in cloned murine natural suppressor cell lines. J Exp Med. 1987; (4): 1168-73
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