Roeland Nusse
Publications
- A localized Wnt signal orients asymmetric stem cell division in vitro. Science. 2013; (6126): 1445-8
- Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 2012; (3): 387-400
- Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Proc Natl Acad Sci U S A. 2012; (2): 370-7
- Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol. 2011; (9): 1070-5
- Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell. 2010; (6): 568-77
- Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 2006; (4): e115
- Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003; (6938): 448-52
- Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells. Proc Natl Acad Sci U S A. 2013; (18): 7324-9
- Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development. 2013; (6): 1196-206
- Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol. 2013; (2)
- Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nat Commun. 2012: 1070
- ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. J Pathol. 2012; (2): 223-33
- Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J. 2012; (12): 2670-84
- Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A. 2012; (21): 8167-72
- Wnt signaling. Cold Spring Harb Perspect Biol. 2012; (5)
- Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol. 2012; (1): 101-14
- A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One. 2011; (11): e26993
- Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis. Cancer Cell. 2011; (4): 415-6
- A crucial role for lipid phosphorylation in WntD-mediated primordial germ cell migration. Dev Biol. 2010; (1): 512
- A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev Dyn. 2010; (1): 184-90
- Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One. 2010; (2): e9370
- Wnt proteins promote bone regeneration. Sci Transl Med. 2010; (29): 29ra30
- Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem. 2009; (44): 30167-76
- Telomerase modulates Wnt signalling by association with target gene chromatin. Nature. 2009; (7251): 66-72
- Towards an integrated view of Wnt signaling in development. Development. 2009; (19): 3205-14
- A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev. 2008; (3): 303-7
- Alternative wnt signaling is initiated by distinct receptors. Sci Signal. 2008; (35): re9
- Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 2008; (6): 1093-105
- Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem. 2008; (25): 17092-8
- Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS One. 2008; (8): e2930
- Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008; (7): e1000111
- Translating insights from development into regenerative medicine: the function of Wnts in bone biology. Semin Cell Dev Biol. 2008; (5): 434-43
- Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development. 2008; (19): 3247-57
- Wnt signaling and stem cell control. Cold Spring Harb Symp Quant Biol. 2008: 59-66
- Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell. 2008; (5): 508-18
- Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2008; (44): 16970-5
- Cancer. Converging on beta-catenin in Wilms tumor. Science. 2007; (5827): 988-9
- Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid. Nat Protoc. 2007; (10): 2325-31
- Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal. PLoS One. 2007; (6): e519
- Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS One. 2007; (9): e945
- Wnt signaling mediates regional specification in the vertebrate face. Development. 2007; (18): 3283-95
- Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A. 2007; (15): 6247-52
- Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology. 2007; (5): 1579-91
- Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells. J Cell Sci. 2006; (Pt 12): 2425-34
- Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila. Genetics. 2005; (4): 2087-100
- Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism. Genetics. 2005; (4): 1643-54
- The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling. EMBO J. 2005; (19): 3493-503
- WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature. 2005; (7059): 746-9
- Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics. 2004; (4): 1775-82
- Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 2004; (5663): 1483-7
- A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics. 2002; (2): 747-62
- A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol. 2002: 8
- Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science. 2002; (5570): 1118-20
- Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002; (44): 41762-9
- Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless. Development. 2002; (14): 3393-402
- Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev. 2001; (6): 658-71
- Interactions between wingless and frizzled molecules in Drosophila. Ernst Schering Res Found Workshop. 2000; (29): 1-11
- Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. Mol Cell. 2000; (1): 117-26
- A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development. 1999; (18): 4165-73
- WNT signaling in the control of hair growth and structure. Dev Biol. 1999; (1): 133-49
- WNT targets. Repression and activation. Trends Genet. 1999; (1): 1-3
- Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev. 1999; (14): 1768-73
- Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev. 1998; (1): 95-102
- DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate. Genes Dev. 1998; (8): 1155-65
- Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development. 1998; (8): 1469-76
- Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell. 1998; (5): 767-77
- A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet. 1997; (3): 465-72
- A versatile transcriptional effector of Wingless signaling. Cell. 1997; (3): 321-3
- Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J. 1997; (11): 3089-96
- Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila. Cold Spring Harb Symp Quant Biol. 1997: 185-90
- Wnt meeting 1996. Biochim Biophys Acta. 1997; (1): R1-5
- Wnt signaling: a common theme in animal development. Genes Dev. 1997; (24): 3286-305
- A new member of the frizzled family from Drosophila functions as a Wingless receptor Nature. 1996
- wingless signaling in the Drosophila eye and embryonic epidermis. Development. 1996; (9): 2801-12
- Differential requirements for segment polarity genes in wingless signaling. Mech Dev. 1995; (2-3): 145-55
- Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer. Semin Cancer Biol. 1995; (3): 127-33
- The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS. Dev Biol. 1995; (1): 202-13
- The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 1995; (9): 1087-97
- Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature. 1994; (6469): 342-4
- Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells. Development. 1994; (5): 1277-86
- Signaling by wingless in Drosophila. Dev Biol. 1994; (2): 396-414
- Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. Dev Suppl. 1993: 105-14
- Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. Genomics. 1993; (3): 790-2
- Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J. 1993; (13): 5293-302
- Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene. 1992; (3): 487-92
- Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development. 1992; (2): 475-85
- Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres. Mech Dev. 1992; (3): 151-60
- The Wnt gene family in tumorigenesis and in normal development. J Steroid Biochem Mol Biol. 1992; (1-3): 9-12
- The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development. 1992; (3): 711-9
- Wnt genes. Cell. 1992; (7): 1073-87
- Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 1991; (3): 381-8
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