William Weis
Publications
- Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity. Prog Mol Biol Transl Sci. 2013: 3-23
- The β-catenin destruction complex. Cold Spring Harb Perspect Biol. 2013; (1): a007898
- An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays. 2012; (10): 833-40
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012; (7398): 321-6
- E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A. 2012; (31): 12568-73
- High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012; (7429): 387-92
- N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One. 2012; (10): e46039
- Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 2012; (7386): 552-6
- Structure of the δ-opioid receptor bound to naltrindole. Nature. 2012; (7398): 400-4
- α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev Cell. 2012; (3): 533-46
- αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A. 2012; (22): 8576-81
- A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science. 2011; (6022): 1336-9
- Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. J Mol Biol. 2011; (2): 519-30
- Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J Mol Biol. 2011; (5): 800-12
- Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 2011; (7366): 549-55
- Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis. Dev Cell. 2011; (1): 32-4
- Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site. J Mol Biol. 2011; (4): 1027-39
- Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell. 2011; (5): 862-73
- Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 2011; (7329): 236-40
- Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 2011; (7329): 175-80
- The beta-catenin binding protein ICAT modulates androgen receptor activity. Mol Endocrinol. 2011; (10): 1677-88
- AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol. 2010; (2): 339-52
- In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010; (33): 14591-6
- Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature. 2010; (7277): 108-12
- Trimeric structure of langerin. J Biol Chem. 2010; (17): 13285-93
- Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J Biol Chem. 2009; (46): 31776-88
- Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR. J Mol Biol. 2009; (4): 613-20
- The first propeller domain of LRP6 regulates sensitivity to DKK1. Mol Biol Cell. 2009; (15): 3552-60
- Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochem Soc Trans. 2008; (Pt 2): 141-7
- Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure. 2008; (5): 715-26
- Structural insights into G-protein-coupled receptor activation. Curr Opin Struct Biol. 2008; (6): 734-40
- A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods. 2007; (11): 927-9
- Catenins: playing both sides of the synapse. Curr Opin Cell Biol. 2007; (5): 551-6
- Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature. 2007; (7168): 383-7
- GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science. 2007; (5854): 1266-73
- High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007; (5854): 1258-65
- Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem. 2007; (6): 4202-9
- Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. J Biol Chem. 2007; (23): 17250-8
- Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol. 2007: 237-61
- Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Nature. 2007; (7135): 567-71
- Crystal structure of the S.cerevisiae exocyst component Exo70p. J Mol Biol. 2006; (1): 9-21
- Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006; (47): 35593-7
- Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem. 2006; (2): 1027-38
- Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell. 2005; (5): 903-15
- Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol. 2005; (4): 364-71
- Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure. 2005; (2): 183-95
- Deconstructing the cadherin-catenin-actin complex. Cell. 2005; (5): 889-901
- Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem. 2005; (2): 1327-35
- Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol. 2005; (1): 367-76
- In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength. Methods Cell Biol. 2004: 757-86
- Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell. 2004; (4): 511-21
- Structural aspects of adherens junctions and desmosomes. Handb Exp Pharmacol. 2004; (165): 23-52
- Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol. 2004; (7): 591-8
- Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J. 2003; (10): 2348-59
- Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem. 2002; (21): 18868-74
- Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol. 2002; (12): 950-7
- ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell. 2002; (3): 573-84
- Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem. 2002; (18): 16088-95
- Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol. 2002; (8): 612-20
- The cytoplasmic face of cell contact sites. Curr Opin Struct Biol. 2002; (2): 255-62
- Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc Natl Acad Sci U S A. 2002; (14): 9184-9
- A novel snare N-terminal domain revealed by the crystal structure of Sec22b. J Biol Chem. 2001; (26): 24203-11
- Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a. J Biol Chem. 2001; (44): 41301-9
- Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. EMBO J. 2001; (22): 6203-12
- Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly. J Biol Chem. 2001; (16): 13273-82
- Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science. 2001; (5549): 2163-6
- The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. J Biol Chem. 2001; (15): 12301-9
- The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell. 2001; (3): 391-402
- Unraveling the mechanism of the vesicle transport ATPase NSF, the N-ethylmaleimide-sensitive factor. J Biol Chem. 2001; (25): 21991-4
- beta-catenin: molecular plasticity and drug design. Trends Biochem Sci. 2001; (11): 672-8
- Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor. J Biol Chem. 2000; (45): 35176-84
- Protein-protein interactions in intracellular membrane fusion. Curr Opin Struct Biol. 2000; (6): 662-71
- Structural basis of the Axin-adenomatous polyposis coli interaction. EMBO J. 2000; (10): 2270-9
- Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J Biol Chem. 2000; (28): 21539-48
- Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell. 2000; (3): 533-43
- Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature. 2000; (6776): 355-62
- Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein. Nat Cell Biol. 1999; (3): 175-82
- Ca2+-dependent structural changes in C-type mannose-binding proteins. Biochemistry. 1998; (51): 17965-76
- Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein. Biochemistry. 1998; (51): 17977-89
- Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein. Cell. 1998; (4): 525-36
- Mechanism of N-acetylgalactosamine binding to a C-type animal lectin carbohydrate-recognition domain. J Biol Chem. 1998; (31): 19502-8
- The C-type lectin superfamily in the immune system. Immunol Rev. 1998: 19-34
- Cell-surface carbohydrate recognition by animal and viral lectins. Curr Opin Struct Biol. 1997; (5): 624-30
- Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides. Biochemistry. 1997; (5): 979-88
- Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell. 1997; (5): 871-82
- Direct observation of protein solvation and discrete disorder with experimental crystallographic phases. Science. 1996; (5245): 72-7
- Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. J Biol Chem. 1996; (2): 663-74
- Structural basis of galactose recognition by C-type animal lectins. J Biol Chem. 1996; (12): 6679-85
- Structural basis of lectin-carbohydrate recognition. Annu Rev Biochem. 1996: 441-73
- Binding of sugar ligands to Ca(2+)-dependent animal lectins. I. Analysis of mannose binding by site-directed mutagenesis and NMR. J Biol Chem. 1994; (22): 15505-11
- Trimeric structure of a C-type mannose-binding protein. Structure. 1994; (12): 1227-40
- Molecular mechanisms of complex carbohydrate recognition at the cell surface. Cold Spring Harb Symp Quant Biol. 1992: 281-9
- Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature. 1992; (6400): 127-34
- Physical characterization and crystallization of the carbohydrate-recognition domain of a mannose-binding protein from rat. J Biol Chem. 1991; (31): 20678-86
- Rigid protein motion as a model for crystallographic temperature factors. Proc Natl Acad Sci U S A. 1991; (7): 2773-7
- Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing. Science. 1991; (5038): 1608-15
- Refinement of the influenza virus hemagglutinin by simulated annealing. J Mol Biol. 1990; (4): 737-61
- The structure of a membrane fusion mutant of the influenza virus haemagglutinin. EMBO J. 1990; (1): 17-24
- Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies. J Biol Chem. 1988; (9): 4474-80
- Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature. 1988; (6172): 426-31
- Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion. J Gen Virol. 1988: 2785-95
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