Laura C. Lazzeroni, Ph.D.

Publications

• A generalized Defries-Fulker regression framework for the analysis of twin data. Lazzeroni LC, Ray A. Behav Genet. 2013; 43 (1): 85-96
• BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. Murphy GM, Sarginson JE, Ryan HS, O'Hara R, Schatzberg AF, Lazzeroni LC. Pharmacogenet Genomics. 2013; 23 (6): 301-13
• Memantine is Associated with Longer Survival than Donepezil in a Veterans Affairs Prescription Database, 1997 to 2008 Lazzeroni LC, Halbauer JD, Ashford JW, Noda A, Hernandez B, Azor V, Hozack N, Hasson N, Henderson VW, Yesavage JA, Tinklenberg JR. Journal of Alzheimer's Disease. 2013 in press
• Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S, Meloy L, Burgos AE, Hall JY, Stevenson DK. J Pediatr. 2013; 162 (3): 477-482.e1
• Serotonin Transporter Polymorphism is associated with increased Apnea-Hypopnea Index in Older Adults Schroder CM, Primeau MM, Hallmayer JF, Lazzeroni LC, Hubbard JT, O'Hara R. Intl J of Geriatric Psychiatry. 2013 in press
• : A Genome-wide Association Study (GWAS) for Bronchopulmonary Dysplasia Wang H, St. Julien KR, Stevenson DK, Hoffman TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jeliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM. Pediatrics. 2013 in press
• Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia. Greenwood TA, Swerdlow NR, Gur RE, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RC, Lazzeroni LC, Nuechterlein KH, Olincy A, Radant AD, Ray A, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Light GA, Braff DL. Am J Psychiatry. 2013; 170 (5): 521-32
• Immune Biomarker Differences and Changes Comparing HCV Mono-Infected, HIV/HCV Co-Infected, and HCV Spontaneously Cleared Patients. Kushner LE, Wendelboe AM, Lazzeroni LC, Chary A, Winters MA, Osinusi A, Kottilil S, Polis MA, Holodniy M. PLoS One. 2013; 8 (4): e60387
• Sex differences in familiality effects on neurocognitive performance in schizophrenia. Calkins ME, Ray A, Gur RC, Freedman R, Green MF, Greenwood TA, Light GA, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar C, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL, Lazzeroni LC, Gur RE. Biol Psychiatry. 2013; 73 (10): 976-84
• Aversive and reinforcing opioid effects: a pharmacogenomic twin study. Angst MS, Lazzeroni LC, Phillips NG, Drover DR, Tingle M, Ray A, Swan GE, Clark JD. Anesthesiology. 2012; 117 (1): 22-37
• Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Walsh R, Nelson P, Medway A, Davis G, Robertson AD, Port JD, Carr J, Murphy GA, Lazzeroni LC, Abraham WT, Liggett SB, Bristow MR. PLoS One. 2012; 7 (10): e44324
• Integrative approach to pain genetics identifies pain sensitivity loci across diseases. Ruau D, Dudley JT, Chen R, Phillips NG, Swan GE, Lazzeroni LC, Clark JD, Butte AJ, Angst MS. PLoS Comput Biol. 2012; 8 (6): e1002538
• Intraindividual Variability in Basic Reaction Time Predicts Middle-Aged and Older Pilots' Flight Simulator Performance. Kennedy Q, Taylor J, Heraldez D, Noda A, Lazzeroni LC, Yesavage J. J Gerontol B Psychol Sci Soc Sci. 2012
• Neuropsychiatric symptoms, apolipoprotein E gene, and risk of progression to cognitive impairment, no dementia and dementia: the Aging, Demographics, and Memory Study (ADAMS). Beaudreau SA, Kaci Fairchild J, Spira AP, Lazzeroni LC, O'Hara R. Int J Geriatr Psychiatry. 2012
• Pain sensitivity and opioid analgesia: a pharmacogenomic twin study. Angst MS, Phillips NG, Drover DR, Tingle M, Ray A, Swan GE, Lazzeroni LC, Clark JD. Pain. 2012; 153 (7): 1397-409
• The cost of large numbers of hypothesis tests on power, effect size and sample size. Lazzeroni LC, Ray A. Mol Psychiatry. 2012; 17 (1): 108-14
• Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Greenwood TA, Lazzeroni LC, Murray SS, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Gur RE, Gur RC, Hardiman G, Kelsoe JR, Leonard S, Light GA, Nuechterlein KH, Olincy A, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Freedman R, Braff DL. Am J Psychiatry. 2011; 168 (9): 930-46
• Influences of APOE ε4 and expertise on performance of older pilots. Taylor JL, Kennedy Q, Adamson MM, Lazzeroni LC, Noda A, Murphy GM, Yesavage JA. Psychol Aging. 2011; 26 (2): 480-7
• Length of prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants: effects on neonatal adaptation and psychomotor development. Casper RC, Gilles AA, Fleisher BE, Baran J, Enns G, Lazzeroni LC. Psychopharmacology (Berl). 2011; 217 (2): 211-9
• Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. Sarginson JE, Killen JD, Lazzeroni LC, Fortmann SP, Ryan HS, Schatzberg AF, Murphy GM. Am J Med Genet B Neuropsychiatr Genet. 2011; 156B (3): 275-84
• ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression. Sarginson JE, Lazzeroni LC, Ryan HS, Ershoff BD, Schatzberg AF, Murphy GM. Pharmacogenet Genomics. 2010; 20 (8): 467-75
• An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. Circ Heart Fail. 2010; 3 (1): 21-8
• FKBP5 polymorphisms and antidepressant response in geriatric depression. Sarginson JE, Lazzeroni LC, Ryan HS, Schatzberg AF, Murphy GM. Am J Med Genet B Neuropsychiatr Genet. 2010; 153B (2): 554-60
• Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Strnad P, Zhou Q, Hanada S, Lazzeroni LC, Zhong BH, So P, Davern TJ, Lee WM, Omary MB. Gastroenterology. 2010; 139 (3): 828-35, 835.e1-3
• Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Angst MS, Phillips NG, Drover DR, Tingle M, Galinkin JL, Christians U, Swan GE, Lazzeroni LC, Clark JD. Twin Res Hum Genet. 2010; 13 (5): 412-25
• A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care setting. Sundaram V, Lazzeroni LC, Douglass LR, Sanders GD, Tempio P, Owens DK. Int J STD AIDS. 2009; 20 (8): 527-33
• Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study. Wroolie TE, Kenna HA, Williams KE, Powers BN, Holcomb M, Lazzeroni L, Rasgon NL. Acta Neurol Scand. 2009; 119 (3): 172-9
• Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study. Jamison RL, Shih MC, Humphries DE, Guarino PD, Kaufman JS, Goldfarb DS, Warren SR, Gaziano JM, Lavori P. Am J Kidney Dis. 2009; 53 (5): 779-89
• Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E. Selwood SP, Parvathy S, Cordell B, Ryan HS, Oshidari F, Vincent V, Yesavage J, Lazzeroni LC, Murphy GM. Neurobiol Aging. 2009; 30 (4): 574-90
• Identification of a major susceptibility locus for lethal graft-versus-host disease in MHC-matched mice. Cao TM, Lazzeroni LC, Tsai S, Pang WW, Kao A, Camp NJ, Thomas A, Shizuru JA. J Immunol. 2009; 183 (1): 462-9
• Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Taylor MR, Slavov D, Humphrey K, Zhao L, Cockroft J, Zhu X, Lavori P, Bristow MR, Mestroni L, Lazzeroni LC. Pharmacogenet Genomics. 2009; 19 (1): 35-43
• Physiological correlates of social avoidance behavior in children and adolescents with fragile x syndrome. Hall SS, Lightbody AA, Huffman LC, Lazzeroni LC, Reiss AL. J Am Acad Child Adolesc Psychiatry. 2009; 48 (3): 320-9
• Purified hematopoietic stem cell allografts reconstitute immunity superior to bone marrow. Tsao GJ, Allen JA, Logronio KA, Lazzeroni LC, Shizuru JA. Proc Natl Acad Sci U S A. 2009; 106 (9): 3288-93
• Trends in US autism research funding. Singh J, Illes J, Lazzeroni L, Hallmayer J. J Autism Dev Disord. 2009; 39 (5): 788-95
• HIV testing of at risk patients in a large integrated health care system. Owens DK, Sundaram V, Lazzeroni LC, Douglass LR, Tempio P, Holodniy M, Sanders GD, Shadle VM, McWhorter VC, Agoncillo T, Haren N, Chavis D, Borowsky LH, Yano EM, Jensen P, Simberkoff MS, Bozzette SA. J Gen Intern Med. 2007; 22 (3): 315-20
• Prevalence of HIV infection among inpatients and outpatients in Department of Veterans Affairs health care systems: implications for screening programs for HIV. Owens DK, Sundaram V, Lazzeroni LC, Douglass LR, Sanders GD, Taylor K, VanGroningen R, Shadle VM, McWhorter VC, Agoncillo T, Haren N, Nyland J, Tempio P, Khayr W, Dietzen DJ, Jensen P, Simberkoff MS, Bozzette SA, Holodniy M. Am J Public Health. 2007; 97 (12): 2173-8
• Prevalence of desmin mutations in dilated cardiomyopathy. Taylor MR, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori P, Mestroni L. Circulation. 2007; 115 (10): 1244-51
• A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, Port JD, Lavori PW, Bristow MR. Proc Natl Acad Sci U S A. 2006; 103 (30): 11288-93
• Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Strnad P, Lienau TC, Tao GZ, Lazzeroni LC, Stickel F, Schuppan D, Omary MB. Hepatology. 2006; 43 (6): 1354-63
• The effect of diagnosis with HIV infection on health-related quality of Life. Honiden S, Sundaram V, Nease RF, Holodniy M, Lazzeroni LC, Zolopa A, Owens DK. Qual Life Res. 2006; 15 (1): 69-82
• Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study). Zolopa AR, Lazzeroni LC, Rinehart A, Vezinet FB, Clavel F, Collier A, Conway B, Gulick RM, Holodniy M, Perno CF, Shafer RW, Richman DD, Wainberg MA, Kuritzkes DR. Clin Infect Dis. 2005; 41 (1): 92-9
• Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy. Sanders GD, Bayoumi AM, Sundaram V, Bilir SP, Neukermans CP, Rydzak CE, Douglass LR, Lazzeroni LC, Holodniy M, Owens DK. N Engl J Med. 2005; 352 (6): 570-85
• The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure. Kolek MJ, Carlquist JF, Thaneemit-Chen S, Lazzeroni LC, Whiting BM, Horne BD, Muhlestein JB, Lavori P, Anderson JL. J Card Fail. 2005; 11 (9): 677-83
• Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Wu HI, Brown JA, Dorie MJ, Lazzeroni L, Brown JM. Cancer Res. 2004; 64 (11): 3940-8
• A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Noble JA, White AM, Lazzeroni LC, Valdes AM, Mirel DB, Reynolds R, Grupe A, Aud D, Peltz G, Erlich HA. Diabetes. 2003; 52 (6): 1579-82
• Allele sharing and allelic association I: sib pair tests with increased power. Lazzeroni LC, Genet Epidemiol. 2002; 22 (4): 328-44
• Association of IL4R haplotypes with type 1 diabetes. Mirel DB, Valdes AM, Lazzeroni LC, Reynolds RL, Erlich HA, Noble JA. Diabetes. 2002; 51 (11): 3336-41
• Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy in HIV infected patients: natural history and clinical predictors. Lin DY, Warren JF, Lazzeroni LC, Wolitz RA, Mansour SE. Retina. 2002; 22 (3): 268-77
• Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. Traynor J, Agarwal P, Lazzeroni L, Francke U. BMC Med Genet. 2002: 3 12
• Genotype to phenotype: associations, errors and complexity. Lazzeroni LC, Karlovich CA. Trends Genet. 2002; 18 (6): 283-4
• Plaid models for gene expression data Lazzeroni L.C., Owen A.. Statistica Sinica. 2002
• A chronology of fine-scale gene mapping by linkage disequilibrium. Lazzeroni LC, Stat Methods Med Res. 2001; 10 (1): 57-76
• A high-resolution radiation hybrid map of the human genome draft sequence. Olivier M, Aggarwal A, Allen J, Almendras AA, Bajorek ES, Beasley EM, Brady SD, Bushard JM, Bustos VI, Chu A, Chung TR, De Witte A, Denys ME, Dominguez R, Fang NY, Foster BD, Freudenberg RW, Hadley D, Hamilton LR, Jeffrey TJ, Kelly L, Lazzeroni L, Levy MR, Lewis SC, Liu X, Lopez FJ, Louie B, Marquis JP, Martinez RA, Matsuura MK, Misherghi NS, Norton JA, Olshen A, Perkins SM, Perou AJ, Piercy C, Piercy M, Qin F, Reif T, Sheppard K, Shokoohi V, Smick GA, Sun WL, Stewart EA, Fernando J, Tejeda, Tran NM, Trejo T, Vo NT, Yan SC, Zierten DL, Zhao S, Sachidanandam R, Trask BJ, Myers RM, Cox DR. Science. 2001; 291 (5507): 1298-302
• Statistical refinement of primer design parameters. Beasley EM, Myers RM, Cox DR, Lazzeroni LC. PCR Applications: Protocols for Functional Genomics. 1999
• A conditional inference framework for extending the transmission/disequilibrium test. Lazzeroni LC, Lange K. Hum Hered. 1998 Mar-Apr; 48 (2): 67-81
• Linkage disequilibrium and gene mapping: an empirical least-squares approach. Lazzeroni LC, Am J Hum Genet. 1998; 62 (1): 159-70
• Random-effects models for smoothing post-stratification weights Lazzeroni LC, Little RJA. Journal of Official Statistics. 1998: 14 61-78
• Markov chains for Monte Carlo tests of genetic equilibrium Lazzeroni L.C., Lange K.. Annals of Statistics. 1997
• In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. Lech WJ, Wang G, Yang YL, Chee Y, Dorman K, McCrae D, Lazzeroni LC, Erickson JW, Sinsheimer JS, Kaplan AH. J Virol. 1996; 70 (3): 2038-43
• Individual variation in recombination among human males. Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N. Am J Hum Genet. 1996; 59 (6): 1186-92
• Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis? Schmitt K, Lazzeroni LC, Foote S, Vollrath D, Fisher EM, Goradia TM, Lange K, Page DC, Arnheim N. Am J Hum Genet. 1994; 55 (3): 423-30
• Multipoint mapping calculations for sperm-typing data. Lazzeroni LC, Arnheim N, Schmitt K, Lange K. Am J Hum Genet. 1994; 55 (3): 431-6
• Models for smoothing post-stratification weights Lazzeroni LC, Little RJA. Proceedings of the Survey Research Methods Section, ASA. 1993: 764-769
• Robustness of multiple-imputation techniques to model misspecification Lazzeroni LC, Schenker N, Taylor JMG. Proc. Survey Research Methods Section, ASA. 1990: 260-265