James L. Zehnder, M.D.
Publications
- 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. Leuk Lymphoma. 2013; (2): 408-10
- A distinct evolution of the T cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease. Blood. 2013
- Desktop transcriptome sequencing from archival tissue to identify clinically relevant translocations. Am J Surg Pathol. 2013; (6): 796-803
- Discordant aPTT and anti-Xa values and outcomes in hospitalized patients treated with intravenous unfractionated heparin. Ann Pharmacother. 2013; (2): 151-8
- Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma. Adv Anat Pathol. 2013; (3): 137-40
- Minimal residual disease quantification using consensus primers and high-throughput IGH sequencing predicts post-transplant relapse in chronic lymphocytic leukemia. Leukemia. 2013
- STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. Leukemia. 2013
- Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica. 2013; (4): 591-6
- Aggressive EBV-associated lymphoproliferative disorder: a prodrome to diffuse large B-cell lymphoma? Appl Immunohistochem Mol Morphol. 2012; (3): 325-30
- Controversies in heparin monitoring. Am J Hematol. 2012: S137-40
- Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence. Blood. 2012; (25): 6145-54
- Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia. Leukemia. 2012; (5): 893-901
- Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia. Am J Hematol. 2012; (1): 45-50
- TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2012; (11): 1619-28
- A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia. Blood. 2011; (26): 6988-90
- Clonally identical Hodgkin's disease develops after allogeneic hematopoietic cell transplant for CLL. Bone Marrow Transplant. 2011; (12): 1576-8
- Evaluation of a gene expression microarray-based assay to determine tissue type of origin on a diverse set of 49 malignancies. Am J Surg Pathol. 2011; (7): 1030-7
- High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment. Proc Natl Acad Sci U S A. 2011; (52): 21194-9
- Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells. J Virol. 2011; (9): 4095-110
- Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies. Leukemia. 2011; (9): 1439-43
- The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP. Blood. 2011; (17): 4569-79
- Varicella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesis. J Virol. 2011; (1): 98-111
- Anti-glycoprotein H antibody impairs the pathogenicity of varicella-zoster virus in skin xenografts in the SCID mouse model. J Virol. 2010; (1): 141-52
- Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatoses. J Mol Diagn. 2010; (3): 320-7
- Complete donor T-cell engraftment 30 days after allogeneic transplantation predicts molecular remission in high-risk chronic lymphocytic leukaemia. Br J Haematol. 2010; (5): 637-9
- Comprehensive and efficient HBB mutation analysis for detection of beta-hemoglobinopathies in a pan-ethnic population. Am J Clin Pathol. 2010; (5): 700-7
- Design and evaluation of a real-time PCR assay for quantification of JAK2 V617F and wild-type JAK2 transcript levels in the clinical laboratory. J Mol Diagn. 2010; (1): 58-64
- Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. Am J Clin Pathol. 2010; (6): 955-63
- Development of antibodies to human thrombin and factor V in a pediatric patient exposed to topical bovine thrombin. Pediatr Blood Cancer. 2010; (6): 1195-7
- Future research in ITP: an ICIS consensus. Ann Hematol. 2010
- Heparin-induced thrombocytopenia: current status and diagnostic challenges. Am J Hematol. 2010; (9): 700-6
- Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. Hum Pathol. 2010; (8): 1200-3
- Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J Immunol. 2010; (12): 6986-92
- Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010; (6): 988-92
- Presentation of extranodal natural killer T-cell lymphoma, nasal type, with poorly circumscribed erythematous patches. J Clin Oncol. 2010; (6): e94-5
- Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. Blood. 2009; (9): 1906-8
- Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009; (10): 3925-9
- Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology. J Mol Diagn. 2009; (1): 4-11
- Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci Transl Med. 2009; (12): 12ra23
- Molecular stratification of patients with normal karyotype acute myeloid leukemia based on initial assessment of FLT3-internal tandem duplication status at first complete remission. Leuk Lymphoma. 2009; (5): 851-3
- Gene expression and pathway analysis of immune thrombocytopenic purpura. Br J Haematol. 2008; (1): 99-103
- Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008; (1): 67-77
- Superficial venous thrombosis associated with congenital absence of the inferior vena cava and previous episode of deep venous thrombosis. Am J Hematol. 2008; (3): 250-2
- Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I. Proc Natl Acad Sci U S A. 2007; (35): 14086-91
- Antithrombotic therapy and pregnancy: consensus report and recommendations for prevention and treatment of venous thromboembolism and adverse pregnancy outcomes. Am J Obstet Gynecol. 2007; (5): 457.e1-21
- Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial. Blood Coagul Fibrinolysis. 2007; (8): 787-93
- Identification of an intronic single nucleotide polymorphism leading to allele dropout during validation of a CDH1 sequencing assay: implications for designing polymerase chain reaction-based assays. Genet Med. 2007; (11): 752-60
- International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia. 2007; (5): 956-64
- Laboratory testing for heparin-induced thrombocytopenia is inconsistent in North America: a survey of North American specialized coagulation laboratories. Thromb Haemost. 2007; (6): 1357-61
- Molecular characterization and subcellular localization of Tyr478del: a pathogenic in-frame deletion in coagulation factor V. J Thromb Haemost. 2007; (2): 431-3
- Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet Assoc. 2007; (3): 422-32
- Severe coagulation factor V deficiency associated with an interstitial deletion of chromosome 1q. J Thromb Haemost. 2007; (3): 626-8
- T-cell clonality analysis in biopsy specimens from two different skin sites shows high specificity in the diagnosis of patients with suggested mycosis fungoides. J Am Acad Dermatol. 2007; (5): 782-90
- Testing for maternal cell contamination in prenatal samples: a comprehensive survey of current diagnostic practices in 35 molecular diagnostic laboratories. J Mol Diagn. 2007; (3): 394-400
- Detection of the JAK2 V617F mutation by LightCycler PCR and probe dissociation analysis. J Mol Diagn. 2006; (3): 330-4
- First molecular characterization of a patient with combined factor V and factor VII deficiency. Thromb Haemost. 2006; (6): 1031-2
- Gene expression patterns in human placenta. Proc Natl Acad Sci U S A. 2006; (14): 5478-83
- Gene expression profile of idiopathic thrombocytopenic purpura (ITP). Pediatr Blood Cancer. 2006; (5 Suppl): 675-7
- Maintenance rituximab following induction chemoimmunotherapy may prolong progression-free survival in mantle cell lymphoma: a pilot study from the Wisconsin Oncology Network. Ann Oncol. 2006; (9): 1418-23
- Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest. 2006; (6): 1633-41
- Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med. 2006; (3): 342-7
- The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006; (16): 6224-9
- A comparison study of different PCR assays in measuring circulating plasma epstein-barr virus DNA levels in patients with nasopharyngeal carcinoma. Clin Cancer Res. 2005; (16): 5700-7
- Characterization of a novel prothrombin variant, Prothrombin C20209T, as a modifier of thrombotic risk among African-Americans. J Thromb Haemost. 2005; (10): 2357-9
- High frequency of premature termination mutations in the factor V gene: three factor V deficiency case reports and a mutation review. Thromb Haemost. 2005; (3): 610-1
- Identification of mislabeled specimen by molecular methods: case report and review. Int J Surg Pathol. 2005; (3): 253-8
- Varicella-zoster virus infection of human dorsal root ganglia in vivo. Proc Natl Acad Sci U S A. 2005; (18): 6490-5
- Congenital and acquired thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2004: 390-406
- CyclinD1/CyclinD3 ratio by real-time PCR improves specificity for the diagnosis of mantle cell lymphoma. J Mol Diagn. 2004; (2): 84-9
- Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004; (7): 657-67
- Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. J Am Soc Nephrol. 2004; (2): 420-6
- Rapid combined genotyping assay for four achondroplasia and hypochondroplasia mutations by real-time PCR with multiple detection probes. Genet Test. 2004; (2): 185-9
- Comprehensive validation of a real-time quantitative bcr-abl assay for clinical laboratory use. Am J Clin Pathol. 2003; (1): 42-8
- Diagnostic single nucleotide polymorphism analysis of factor V Leiden and prothrombin 20210G > A. A comparison of the Nanogen Eelectronic Microarray with restriction enzyme digestion and the Roche LightCycler. Am J Clin Pathol. 2003; (4): 490-6
- Heterozygous prothrombin G20210A gene mutation in a patient with livedoid vasculitis. Arch Dermatol. 2003; (8): 1081-3
- Lack of human herpesvirus 8 and Epstein-Barr virus in Kikuchi's histiocytic necrotizing lymphadenitis. Hum Pathol. 2003; (2): 130-5
- Lymphomatoid papulosis associated with mycosis fungoides: a study of 21 patients including analyses for clonality. J Am Acad Dermatol. 2003; (4): 620-3
- Prothrombin gene variants in non-Caucasians with fetal loss and intrauterine growth retardation. J Mol Diagn. 2003; (4): 250-3
- Homozygous factor V splice site mutation associated with severe factor V deficiency. Blood. 2002; (8): 3063-5
- Novel factor V C2-domain mutation (R2074H) in two families with factor V deficiency and bleeding. Thromb Haemost. 2002; (2): 294-9
- Psoriasiform mycosis fungoides with fatal outcome after treatment with cyclosporine. J Am Acad Dermatol. 2002; (1): 155-7
- A polymorphism in the BCL-6 gene is associated with follicle center lymphoma. Leuk Lymphoma. 2001 Nov-Dec; (6): 1343-50
- An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. Kidney Int. 2001; (3): 1106-13
- CD31 mismatching affects marrow transplantation outcome. Biol Blood Marrow Transplant. 2001; (9): 503-12
- Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. Blood. 2001; (4): 945-51
- Immunological consequences of topical bovine thrombin. Am J Pathol. 2001; (6): 2371
- Antibodies against the first Ig-like domain of human platelet endothelial cell adhesion molecule-1 (PECAM-1) that inhibit PECAM-1-dependent homophilic adhesion block in vivo neutrophil recruitment. J Immunol. 2000; (1): 452-62
- Blastic/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases. Am J Surg Pathol. 2000; (4): 525-34
- PCR-heteroduplex analysis of T-cell receptor gamma gene rearrangement in paraffin-embedded skin biopsies. Am J Dermatopathol. 2000; (4): 321-7
- Peripheral T-cell lymphoma complicated by a proliferation of large B cells. Am J Clin Pathol. 2000; (2): 236-47
- Sensitive detection of clonal immunoglobulin rearrangements in frozen and paraffin embedded tissues by polymerase chain reaction heteroduplex analysis. Diagn Mol Pathol. 2000; (4): 177-83
- Aggressive cutaneous NK and NK-like T-cell lymphomas: clinicopathologic, immunohistochemical, and molecular analyses of 12 cases. Am J Surg Pathol. 1999; (5): 571-81
- Aggressive natural killer-like T-cell malignancy with leukemic presentation following solid organ transplantation. Am J Clin Pathol. 1999; (5): 663-71
- Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford [erratum]. Thromb Haemost. 1999; (5): XII
- Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford. Thromb Haemost. 1999; (3): 1097-9
- Mast-cell heparin demystified. Nature. 1999; (6746): 714-5
- Real-time t(11;14) and t(14;18) PCR assays provide sensitive and quantitative assessments of minimal residual disease (MRD). Leukemia. 1999; (11): 1833-42
- The International Normalized Ratio during concurrent warfarin and argatroban anticoagulation: differential contributions of each agent and effects of the choice of thromboplastin used. Clin Chem. 1999; (3): 409-12
- Use of the polymerase chain reaction in the evaluation of cutaneous T-cell infiltrates. Dermatol Clin. 1999; (3): 657-66, x
- Variability of polymerase chain reaction detection of the bcl-2-IgH translocation in an international multicentre study. Ann Oncol. 1999; (11): 1349-54
- Factor V Leiden and the risk of proximal venous thrombosis after total hip arthroplasty. J Arthroplasty. 1998; (2): 207-10
- Mesenteric artery thrombosis: a case report of combined protein S and protein C deficiency. Am J Hematol. 1998; (3): 246-7
- A microplate allele-specific oligonucleotide hybridization assay for detection of factor V Leiden. Diagn Mol Pathol. 1997; (6): 347-52
- Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. Blood. 1997; (4): 1452-9
- Cross-linking hybridization assay for direct detection of factor V Leiden mutation. Clin Chem. 1997; (9): 1703-8
- Heparin-induced platelet aggregation vs platelet factor 4 enzyme-linked immunosorbent assay in the diagnosis of heparin-induced thrombocytopenia-thrombosis. Am J Clin Pathol. 1997; (1): 78-82
- Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. N Engl J Med. 1996; (5): 286-91
- Recurrent thrombosis due to compound heterozygosity for factor V Leiden and factor V deficiency. Blood Coagul Fibrinolysis. 1996; (3): 361-2
- Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden. Am J Clin Pathol. 1996; (1): 107-11
- Histidine-rich glycoprotein: is there a role in hemostasis or immune function? J Lab Clin Med. 1995; (6): 682-3
- Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrane-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide. Blood. 1995; (5): 1282-8
- The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes. J Biol Chem. 1992; (8): 5243-9
- Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin. Blood. 1990; (10): 2011-6
- Torsades de pointes precipitated by a Chinese herbal remedy. Am J Cardiol. 1987; (14): 1186-7
- Reinvestigation of the reaction of chymotrypsin with N-furylacryloyltryptophan derivatives at acidic pH. Biochem J. 1979; (3): 733-6
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