Laura Attardi

Publications

• Deconstructing p53 transcriptional networks in tumor suppression. Bieging KT, Attardi LD. Trends Cell Biol. 2012; 22 (2): 97-106
• Desmosomes: new perpetrators in tumour suppression. Dusek RL, Attardi LD. Nat Rev Cancer. 2011; 11 (5): 317-23
• Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, Kenzelmann Broz D, Basak S, Park EJ, McLaughlin ME, Karnezis AN, Attardi LD. Cell. 2011; 145 (4): 571-83
• Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Jiang D, Brady CA, Johnson TM, Lee EY, Park EJ, Scott MP, Attardi LD. Proc Natl Acad Sci U S A. 2011; 108 (41): 17123-8
• The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD, Brunet A. Oncogene. 2011; 30 (29): 3207-21
• In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Kenzelmann Broz D, Attardi LD. Carcinogenesis. 2010; 31 (8): 1311-8
• Loss of the desmosomal component perp impairs wound healing in vivo. Beaudry VG, Ihrie RA, Jacobs SB, Nguyen B, Pathak N, Park E, Attardi LD. Dermatol Res Pract. 2010: 2010 759731
• Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD. PLoS Genet. 2010; 6 (10): e1001168
• p53 at a glance. Brady CA, Attardi LD. J Cell Sci. 2010; 123 (Pt 15): 2527-32
• Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Beaudry VG, Pathak N, Koster MI, Attardi LD. Am J Med Genet A. 2009; 149A (9): 1952-7
• Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. Nguyen B, Dusek RL, Beaudry VG, Marinkovich MP, Attardi LD. J Invest Dermatol. 2009; 129 (7): 1710-8
• SKP-ing TAp63: stem cell depletion, senescence, and premature aging. Beaudry VG, Attardi LD. Cell Stem Cell. 2009; 5 (1): 1-2
• Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Johnson TM, Meade K, Pathak N, Marques MR, Attardi LD. Proc Natl Acad Sci U S A. 2008; 105 (4): 1215-20
• Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. McGowan KA, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, de Angelis MH, Myers RM, Attardi LD, Barsh GS. Nat Genet. 2008; 40 (8): 963-70
• The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD. Mol Cell. 2008; 30 (3): 303-14
• A healthy tan? Barsh G, Attardi LD. N Engl J Med. 2007; 356 (21): 2208-10
• Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Jacobs SB, Basak S, Murray JI, Pathak N, Attardi LD. Cell Death Differ. 2007; 14 (7): 1374-85
• Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes. Ihrie RA, Bronson RT, Attardi LD. Cell Death Differ. 2006; 13 (9): 1614-8
• Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice. Johnson TM, Attardi LD. Cell Death Differ. 2006; 13 (6): 902-8
• Genome-wide analysis of p53 under hypoxic conditions. Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Mol Cell Biol. 2006; 26 (9): 3492-504
• The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. Marques MR, Ihrie RA, Horner JS, Attardi LD. J Invest Dermatol. 2006; 126 (1): 69-73
• A new Perp in the lineup: linking p63 and desmosomal adhesion. Ihrie RA, Attardi LD. Cell Cycle. 2005; 4 (7): 873-6
• Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. Marques MR, Horner JS, Ihrie RA, Bronson RT, Attardi LD. Cancer Res. 2005; 65 (15): 6551-6
• Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Artandi SE, Attardi LD. Biochem Biophys Res Commun. 2005; 331 (3): 881-90
• Perp is a p63-regulated gene essential for epithelial integrity. Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD. Cell. 2005; 120 (6): 843-56
• Probing p53 biological functions through the use of genetically engineered mouse models. Attardi LD, Donehower LA. Mutat Res. 2005; 576 (1-2): 4-21
• The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Johnson TM, Hammond EM, Giaccia A, Attardi LD. Nat Genet. 2005; 37 (2): 145-52
• The role of apoptosis in cancer development and treatment response. Brown JM, Attardi LD. Nat Rev Cancer. 2005; 5 (3): 231-7
• The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models. Attardi LD, Mutat Res. 2005; 569 (1-2): 145-57
• p53QS: an old mutant teaches us new tricks. Johnson TM, Attardi LD. Cell Cycle. 2005; 4 (6): 731-4
• Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Attardi LD, de Vries A, Jacks T. Oncogene. 2004; 23 (4): 973-80
• Conquering the complexity of p53. Attardi LD, DePinho RA. Nat Genet. 2004; 36 (1): 7-8
• Developmental context determines latency of MYC-induced tumorigenesis. Beer S, Zetterberg A, Ihrie RA, McTaggart RA, Yang Q, Bradon N, Arvanitis C, Attardi LD, Feng S, Ruebner B, Cardiff RD, Felsher DW. PLoS Biol. 2004; 2 (11): e332
• Perp-etrating p53-dependent apoptosis. Ihrie RA, Attardi LD. Cell Cycle. 2004; 3 (3): 267-9
• Perp is a mediator of p53-dependent apoptosis in diverse cell types. Ihrie RA, Reczek E, Horner JS, Khachatrian L, Sage J, Jacks T, Attardi LD. Curr Biol. 2003; 13 (22): 1985-90
• PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T. Genes Dev. 2000; 14 (6): 704-18
• Transcriptional Activation by p53, but not Induction of the p21 Gene, is Essential for Oncogene-Mediated Apoptosis Attardi, L.D., S.W. Lowe, J. Brugarolas, and T. Jacks. Embo J. 1996 15