Rajat Rohatgi

Publications

• A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. Dorn KV, Hughes CE, Rohatgi R. Dev Cell. 2012; 23 (4): 823-35
• Oxysterols are allosteric activators of the oncoprotein Smoothened. Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Nat Chem Biol. 2012; 8 (2): 211-20
• The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. Genes Dev. 2010; 24 (7): 670-82
• Hedgehog signal transduction by smoothened: pharmacological evidence for a two-step activation process. Rohatgi R, Milenkovic L, Corcoran RB, and Scott MP. Proceedings of the National Academy of Sciences USA. 2009: 106 3196-3201
• Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. Milenkovic L, Scott MP, Rohatgi R. J Cell Biol. 2009; 187 (3): 365-74
• Patched1 regulates Hedgehog signaling at the primary cilium. Rohatgi R, Milenkovic, Scott MP. Science. 2007; 317 (5836): 372-376
• Singapore signalling: the 2012 hedgehog pathway cocktail. Briscoe J, Rohatgi R. EMBO Rep. 2012; 13 (7): 580-3
• The ciliary membrane. Rohatgi R, Snell WJ. Curr Opin Cell Biol. 2010; 22 (4): 541-6
• Arrestin’ Movement in Cilia. Rohatgi R, Scott MP. Science. 2008; 320 (5884): 1777-1781
• Patching the gaps in Hedgehog signaling. Rohatgi R, Scott MP. Nat Cell Bio. 2007; 9 (9): 1005-1009
• In vitro reconstitution of cdc42-mediated actin assembly using purified components. Ho HY, Rohatgi R, Lebensohn A, Kirschner MW. Methods in Enzymology. 2006: 406 174-190
• Loss-of-function Analysis of EphA Receptors in Retinotectal mapping. Feldheim DA, Nakamoto M, Osterfield M, Gale NW, DeChiara TM, Rohatgi R, Yancopoulos GD, Flanagan JG. Journal of Neuroscience. 2004; 24 (10): 2542-2550
• Toca-1 Mediates Cdc42- Dependent Actin Nucleation by Activating the N-WASP-WIP Complex. Ho HY, Rohatgi R, Lebensohn A, Ma L, Li L, Gygi SP, Kirschner MW. Cell. 2004; 118 (2): 203-216
• The Mechanism of Regulation of WAVE1-induced Actin Nucleation by Rac1 and Nck. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, and Kirschner MW. Nature. 2002; 418 (6899): 790-793
• CR16 Forms a Complex with N-WASP in Brain and is a Novel Member of a Conserved Proline-Rich Actin-Binding Protein Family. Ho HY, Rohatgi R, Ma L, and Kirschner MW. Proceedings of the National Academy of Sciences USA. 2001; 98 (20): 11306-11311
• Nck and Phosphatidylinositol 4,5 Bisphosphate Synergistically Activate Actin Polymerization Through the N-WASP-Arp2/3 Pathway. Rohatgi R, Nollau P, Ho HY, Kirschner MW, and Mayer BJ. Journal of Biological Chemistry. 2001; 276 (28): 26448-26452
• WIP Regulates N-WASP-Mediated Actin Polymerization and Filopodium Formation. Martinez-Quiles N, Rohatgi R, Anton IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. Nature Cell Biology. 2001; 3 (5): 484-491
• Mechanism of N-WASP Activation by CDC42 and Phosphatidylinositol 4, 5-Bisphosphate. Rohatgi R, Ho HY, Kirschner MW. Journal of Cell Biology. 2000; 150 (6): 1299-1310
• The Interaction Between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. Cell. 1999; 97 (2): 221-231
• The Arp2/3 Complex Mediates Actin Polymerization Induced by the Small GTP-Binding Protein Cdc42. Ma L, Rohatgi R, Kirschner MW. Proceedings of the National Academy of Sciences USA. 1998; 95 (26): 15362-15367
• Kinetic and Mechanistic Analysis of Non-Enzymatic, Template-Directed Oligoribonucleotide Ligation. Rohatgi R, Bartel DP, Szostak JW. Journal of the American Chemical Society. 1996; 118 (14): 3332-3339
• Non-Enzymatic, Template-Directed Ligation of Oligoribonucleotides is Highly Regioselective for the Formation of 3'-5'-Phosphodiester Bonds Rohatgi R, Bartel DP, Szostak JW. Journal of the American Chemical Society. 1996; 118 (14): 3340-3344