Cancer Institute A national cancer institute
designated cancer center

Department: Stanford Cancer Institute

Cancer Stem Cells

  • Karel H. and Avice N. Beekhuis Professor in Cancer Biology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Clinical Focus
    • Colorectal Cancer
    • Oncology (Cancer)
    • Medical Oncology
    Research Interest

    Dr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.

  • Department of Pathology Professor in Experimental Pathology and Professor of Developmental Biology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Clinical Focus
    • Anatomic/Clinical Pathology
    • Pathology and Laboratory Medicine
    Research Interest

    Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.

  • Assistant Professor of Radiation Oncology
    Member, Stanford Cancer Institute
    Clinical Focus
    • Radiation Oncology
    • Thoracic Oncology
    • Radiation Oncology
    Research Interest

    My laboratory focuses on two main areas: 1) cancer stem cell biology and 2) novel biomarkers for identifying the presence of malignant cells (diagnostic), predicting outcome (prognostic), and predicting response to therapy (predictive). Areas of study include cancers of the lung, breast, and gastrointestinal system. Clinically I specialize in the treatment of lung cancer and applications of stereotactic ablative radiotherapy and perform both prospective and retrospective clinical studies.

  • Lucile Packard Children's Hospital Professor in Pediatric Neurosurgery and, Professor, by courtesy, of Pediatrics at the Stanford University Medical Center
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Clinical Focus
    • Neurological Surgery
    • Brain and Spinal Cord Tumors
    • Neuro-Oncology
  • Assistant Professor of Pediatrics (Endocrinology)
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Clinical Focus
    • Pediatric Endocrinology
    Research Interest

    The overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.

  • Reed-Hodgson Professor in Human Biology and Professor of Genetics
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.

  • Professor of Urology at the Stanford University Medical Center
    Member, Stanford Cancer Institute
    Clinical Focus
    • Urologic Oncology
    • Bladder Cancer - Urologic Oncology
    • Bladder Cancer
    Research Interest

    Benign Prostatic Hyperplasia- Evaluation and development of new minimally invasive techniques

    Endourology: developing, designing and evaluating new instruments

    Bladder cancer: outcomes of treatment

    BPH: cryotherapy and HIFU

  • Associate Professor of Medicine (Hematology) at the Stanford University Medical Center
    Member, Stanford Cancer Institute
    Clinical Focus
    • Hematology
    • Hematology
    Research Interest

    My research interests include phase I/II clinical trial evaluation of novel therapies for the following diseases:
    --Myelodysplastic syndromes (MDS)
    --Chronic myelogenous leukemia (CML)
    --Acute myelogenous leukemia (AML)
    --Myeloproliferative disorders (MPDs) including:
    Hypereosinophilic syndrome
    Systemic mastocytosis
    BCR-ABL-negative MPDs

  • Professor of Neurosurgery and by courtesy of Otolaryngology-Head and Neck Surgery at the Stanford University Medical Center
    Member, Bio-X
    Member, Stanford Cancer Institute
    Clinical Focus
    • Neuro Oncology
    • Acoustic Neuroma
    • Acoustic Neuroma - Head and Neck Surgery
    Research Interest

    Microsurgical treatment of tumors of the brain, spinal cord, pituitary gland and skull base;
    Radiosurgery of tumors;
    Molecular biology of brain tumors.

  • Professor of Otolaryngology - Head and Neck Surgery and, by courtesy, of Neurosurgery at the Stanford University Medical Center
    Member, Stanford Cancer Institute
    Clinical Focus
    • Head and Neck Cancer
    • Head and Neck Cancers
    • Head and Neck Cancers - Head and Neck Surgery
    Research Interest

    1) New therapeutic approaches for head and neck cancer, including immune stimulation possibilities (IRX-2 protocol), integration of biological modifiers, and, eventually, genetic approaches.
    2) Head and neck cancer stem cells: identification, characterization, control--in conjunction with the Irv Weissman and Michael Clarke labs in the Stem Cell Institute
    3) Development of innovative surgical methods at the anterior cranial base

  • Professor of Developmental Biology and, by courtesy, of Medicine (Oncology)
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Research Interest

    We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.

  • The Robert L. and Mary Ellenburg Professor in Surgery
    Member, Stanford Cancer Institute
    Clinical Focus
    • GI Oncology
    • Adrenal Cancer
    • Carcinoid Tumors
    Research Interest

    Interleukin-12 is a Th1 cytokine. It is important in the cell mediated immune response. We are investigating its role as an anti-tumor cytokine to augment the immune response against cancer. We are planning a human trial.

  • Virginia and Daniel K. Ludwig Professor in Cancer Research
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.

  • Associate Professor of Neurosurgery
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Member, Stanford Neurosciences Institute
    Research Interest

    For most areas of the mammalian brain, the production of new nerve cells or neurons is restricted to fetal development. However, there are exceptions to the rule. Some areas of the brain continue to make new neurons throughout life. This neurogenesis is mediated by neural stem cells and our research goals are to understand how stem cell activity and fate are controlled. Ultimately, we hope to harness the nascent potential of stem cells to treat neurological injury and disease.

  • Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
    Member, Bio-X
    Member, Stanford Cancer Institute
    Member, Stanford Neurosciences Institute
    Clinical Focus
    • Neuro Oncology
    • Neurology
    Research Interest

    Our laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.

  • Associate Professor of Medicine (Pulmonary and Critical Care Medicine), Emeritus
    Member, Bio-X
    Member, Stanford Cancer Institute
    Clinical Focus
    • Pulmonology (Lung) and Critical Care
    • Pulmonary Disease
    • Interstitial Lung Disease
    Research Interest

    Our laboratory examines apoptotic and cell signaling pathways in cancer and lung disease. We are studying signaling pathways that regulate oxidative stress responses and cancer cell growth. Part of these studies focus on analysis of non-canonical transcription regulatory functions of the TERC and Tert components of telomerase in lung disease and cancer.

  • Howard H. and Jessie T. Watkins University Professor and Professor of Genetics, Bioengineering and, by courtesy, of Biology
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Faculty Fellow, Stanford ChEM-H
    Member, Stanford Neurosciences Institute
    Research Interest

    Our research is focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We study mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We study a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis.

  • Associate Professor of Medicine (Blood and Marrow Transplantation)
    Member, Stanford Cancer Institute
    Clinical Focus
    • Blood and Marrow Transplant
    • Blood and Marrow Transplantation
    • Hematology
    Research Interest

    Transplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.

  • Associate Professor of Neurosurgery at the Stanford University Medical Center
    Member, Bio-X
    Member, Stanford Cancer Institute
    Clinical Focus
    • Neurological Surgery
    • Neurosurgery
    Research Interest

    My research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII

  • Lui Hac Minh Professor in the School of Medicine
    Member, Stanford Cancer Institute
    Clinical Focus
    • GI Oncology
    • Liver Cancer
    • Liver Cancer - Surgery
    Research Interest

    Through a 4 pronged comprehensive program: translational and clinical research, early detection and treatment, promoting education, awareness and immunization and building partnership, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.

  • Associate Professor of Medicine (Oncology) at the Stanford University Medical Center
    Member, Stanford Cancer Institute
    Clinical Focus
    • Urologic Oncology
    • Bladder Cancer
    • Bladder Cancer - Medical Oncology
    Research Interest

    Clinical interests: general oncology, genito-urinary malignancy Research interests: conducting clinical trials in advanced prostate cancer, bladder cancer and renal cell carcinoma

  • Assistant Professor of Otolaryngology - Head and Neck Surgery
    Member, Stanford Cancer Institute
    Clinical Focus
    • Cutaneous (Dermatologic) Oncology
    • Head and Neck Cancer
    • Thyroid Neoplasms
    Research Interest

    My laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells.

  • Associate Professor of Surgery (Pediatric Surgery) and Pediatrics at the Stanford University Medical Center
    Member, Bio-X
    Member, Child Health Research Institute
    Member, Stanford Cancer Institute
    Clinical Focus
    • Surgery, Pediatric
    • Pediatric Surgery
    Research Interest

    One of the current primary interests of the lab is to investigate the mechanisms by which hepatocellular injury and recovery is influenced and controlled by hepatocyte metabolism.

    A second focus of investigation is to identify molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include newborn sepsis and Necrotizing Enterocolitis (NEC).

  • Associate Professor of Obstetrics and Gynecology (Oncology)
    Member, Stanford Cancer Institute
    Clinical Focus
    • Gynecologic Cancer
    • Cervix Cancer
    • Cervix Cancer - Gynecologic Oncology
    Research Interest

    Gynecologic Malignancies
    Immunotherapy
    Biologic Response Modifiers
    New Drug Development
    Antigenic specificities of human antibodies encoded by the VH4-34 gene

  • Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery, of Neurology and of Comparative Medicine at SUMC
    Member, Stanford Cancer Institute
    Clinical Focus
    • Pathology
    Research Interest

    My research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.

  • Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology &, by courtesy, of Biology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.

  • Stephen R. Pierce Family Goldman Sachs Professor in Science and Human Health, Professor of Health Research and Policy and, by courtesy, of Biology
    Member, Bio-X
    Member, Stanford Cancer Institute
    Research Interest

    Current interest centers on the application of statistics to problems arsing from biology. We are particularly interested in questions concerning gene regulation and signal transduction.

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