Department: Stanford Cancer Institute

Clinical investigation in Hodgkin's disease, non-Hodgkin's Lymphomas and cutaneous lymphomas. Experimental therapeutics with novel chemotherapy and biologically targeted therapies. The research program is highly collaborative with radiation oncology, industry, pathology and dermatology.

My research is focused on attaining a better understanding of the initiation, maintenance, and progression of lymphoid tumors, and their response to immunochemotherapy toward improving current treatment strategies. In this effort, I employ tools from functional genomics, computational biology, molecular genetics, and mouse models. I hope to apply this knowledge towards the design of clinical trials in the treatment of patients with lymphoma, leukemia, and myeloma.

I refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/

Teaching & clinical interests include: Supervision, training, and mentoring of postdoctoral fellows and residents; consultation. Brief and long-term therapy: CBT, IPT, mood regulation & psychodynamic approaches.

Research interest in utilizing post-transplant adoptive cellular immunotherapy to reduce GVHD and relapse in patients with high risk hematologic malignancies.

Telomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging. We are interested in how telomere shortening influences cancer, stem cell function and genomic stability. Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer. We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches.

Our laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.

Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.

Genetic and cell biological analyses of signals controlling cell polarity and morphogenesis. Frizzled signaling and cytoskeletal organization.

Biophysical mechanisms of host defense peptides and their mimics

Applications of computer graphics to medical imaging, with emphasis on diagnosis of bowel pathology using virtual colonoscopy. Dynamic joint imaging with open Magnetic Resonance Imaging system.

Dr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. Through computation and experimentation we investigate the Systems Biology parts-list of many thousands genomic regions involved in gene transcription regulation during embryonic development. Major interests include (1) the origins and evolution of these regions, (2) how they encode their individual as well as combined roles, (3) their contribute to human disease, and (4) their contribute to species adaptation.

1. Role of the G protein coupled receptors in regulating mitochondrial structure and function. 2. Differences between R and L ventricular responses to stress, including gene expression and miR regulation. 3. Using iPSC-derived myocytes to understand heart failure and congenital heart disease. 4. Tools for evaluation of cardiac physiology in transgenic mice and isolated cardiomyocytes. 5. Anti-body mediated rejection. 6. Biomarkers for post-transplant lymphoproliferative disorder.

Studies on apoptotic cell death in vivo using the H MRS phenomenon.

Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.

Use of medical informatics to improve quality delivery in cancer care

Inner ear microendoscopy -- Developing techniques for minimally-invasive imaging of inner ear microanatomy and neural pysiology. Applications include improved cochlear implant development, inner ear regenerative techniques, inner ear surgery, and auditory physiology. Microsurgical robotics -- Developing scalable microsurgical instrumentation and robotic techniques for use in head and neck surgery. Surgical Simulation -- Immersive environment for temporal bone surgical simulation.

Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include: 1) Design and synthesis of novel chemical probes for each of the primary protease families. 2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii. 3) Defining the specific functional roles of proteases during the process of tumorogenesis. 4) In vivo imaging of protease activity

We are intereseted in the interaction between the protozoan parasite Toxoplasma gondii and its mammalian host. We use a combination of molecular and genetic tools to understand how this obligate intracellular parasite can invade almost any cell it encounters, how it co-opts a host cell once inside and how it evades the immune response to produce a life-long, persistent infection.

Research interests: ocular pathology, host-pathogen interactions in infectious disease, infectious disease in frogs, phenotypic characterization of tg and ko mice, histopathology of minimally-invasive radiological ablation techniques (focused ultrasound, cryoablation).

Regulation of expression of oncogenes in normal and malignant hematologic cells.

We use genomic approaches to identify disease biomarkers. We are most interested in translating biomarkers into clinical practice in urological diseases with a particular focus in cancer.

We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy.

Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.

Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.

Nurse Practitioner Stanford Cancer Survivorship Program Manager

Our interests include: 1) The physiology and significance of lymphocyte homing in local and systemic immunity; 2) biochemical and genetic studies of molecules that direct leukocyte recruitment; 3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; 4) vascular differentiation in normal and pathologic inflammatory states; 5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs.

The Butte Lab at Stanford builds and applies tools that convert more than 300 billion points of molecular, clinical, and epidemiological data -- measured by researchers and clinicians over the past decade -- into diagnostics, therapeutics, and new insights into disease.

Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.

Clinical investigations in breast cancer include institutional and NSABP studies of chemoprevention, adjuvant therapy, psychosocial interventions, treatment of metastatic disease, methods of decreasing anthracycline cardiotoxicity, and modulation of multidrug resistance. Research in meta-analysis includes the performance of meta-analysis in a wide variety of settings in cancer treatment by the international Meta-Analysis Group in Cancer.

Molecular mechanisms of intestinal cell growth control; function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells.

Dr. Chang's research interests and activities include: • The etiology of virus-associated malignancies, including Hodgkin lymphoma, nasopharyngeal carcinoma, and hepatocellular carcinoma • The etiologic role of immune-related risk factors in cancer, especially lymphoid malignancies • The prevention of hepatitis B and hepatocellular carcinoma • Racial/ethnic disparities in cancer incidence and survival, particularly among Asians and Asian Americans

Our research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.

Our current studies focus on aging and skin cancers in human beings and are translational in nature: 1) genetics and epigenetics to promote healthy aging of the skin 2) genetics and epigenetics of skin cancers and drug resistance 3) novel therapies to promote healthy aging of the skin 4) novel therapies for non-melanoma skin cancers 5) induced pluripotent stem cells for regenerative and therapeutic purposes

Clinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine. Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program. Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.

Our laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

We study the genetic networks controlled by regulatory RNAs, such as microRNAs (miRNAs), and currently focus on two complementary aspects of miRNA biology: (1) The roles of miRNAs in modulating the development, function, and pathogenesis of vertebrate immune systems and (2) the mechanisms by which these regulatory RNAs control gene expression.

We are dedicated to develop multifunctional molecular probes for multimodality imaging and bioconjugates for target-specific drug delivery. The research tools include bioconjugation chemistry, radiochemistry (PET/SPECT), nanotechnology, and stem cell biology.

The use of molecular and molecular cytogenetic methods to identify chromosomal abnormalities in acquired and congenital disorders.

Dr. Cheung's research interests focus on liver diseases, with emphasis on viral hepatitis. His past research include investigating the mechanism of viral neutralization of hepatitis B virus at the molecular level and immune response to hepatitis C virus. Dr. Cheung is studing various aspects of hepatitis C, both clinical and translational research.

Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage.

Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms b..

Renal cell carcinoma and prostate cancer outcomes research and epidemiology.

The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability.

Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine. In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa..

Dr. Clarke’s research efforts are centered in five areas: 1) the epidemiology of breast cancer, 2) the epidemiology of lymphoid malignancies 3) immunologic and viral causes of malignancy, and 4) cancer surveillance and creative uses of and ways to visually display cancer surveillance data (e.g, SEER, cancer registry data) and more recently, 5) internet-based, patient-centric methods for recruitment and data collection in epidemiologic studies.

The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer.

Molecular Bioengineering, Protein Biochemistry and Biotechnology, Cell and Tissue Engineering, Molecular Imaging

We study RNA decay and mechanisms that affect microbial antibiotic resistance, as well as the exploitation of host genes by pathogens. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.

Multi- modality treatment of Head and Neck Cancer Phase 1 clinical trials

1. Pharmacologic methods in identifying alpha adrenergic receptors in the obstructed urinary tract. 2. Fluid mechanics and physiological mechanisms of contractility in the urinary tract. 3. Biomedical Engineering approaches in the characterization of static and dynamic properties of soft tissues. 4. Image processing and 3D reconstruction of magnetic resonance. 5. Computer models and vector analysis of pelvin floor musculature. 6. Software for interactive teaching.

We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

My research integrates clinical care of patients with novel treatments for a variety of hematologic disorders. I see patients with a wide range of problems with a particular focus on chronic lymphocytic leukemia and multiple myeloma. I provide comprehensive consultative services as well as treatment for both the acute and chronic leukemias as well as non-malignant conditions such as clotting disorders and thrombocytopenia.

Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.

I am exploring the role of spirituality and religion as an intervention for improving outcomes and health delivery in three clinical domains: end-of-life care; cancer; and conditions causing cognitive impairment. To this end, I completed a sabbatical undertaking a one-year Clinical Pastoral Residency for chaplaincy training at the Alta Bates Summit Medical Center (2011 - 2012) with the goals: to develop skills in providing spiritual companionship to patients; to broaden my competencies as..

Mortality in patients with cutaneous melanoma arises from metastasis, usually to the lymph nodes followed by distant metastases to solid organs. We demonstrated that the extent of tumor lymphangiogenesis can predict the risk of metastasis to distant and sentinel lymph nodes in patients with melanoma. Using large-scale molecular screening, we study the genetic and epigenetic events regulating melanoma lymphangiogenesis, coupled with histological and clinical data.

Hematology/Oncology, Phase I drug studies for childhood cancer, overcoming multidrug resistance in leukemia and solid tumors, biology and treatment of acute nonlymphocytic leukemia, early detection of central nervous system leukemia by measuring growth, factor binding proteins.

Our Research Group develops non-invasive cellular imaging techniques that can generate detailed information about specific cell populations in the body. The ultimate goal of this research is to determine tumor characteristics which are linked to poor prognosis, to develop, direct and monitor related targeted therapies and to monitor stem cell therapies that regenerate physiologic cell populations. We have a strong focus on translational, bench-to-bedside research.

Advanced MRI imaging for laryngeal cancer and swallowing disorders; applications of robotics in microlaryngeal surgery; high speed digital imaging of vocal fold vibration; the effects of hormones and anabolic steroids on vocal function.

1. MRI of Breast Cancer, particularly new techniques. Currently being explored are techniques including ultra high spatial resolution MRI and contrast-agent-free detection of breast tumors. 2. MRI-guided interventions, especially MRI-guided cryosurgery of prostate cancer

Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes. Dynamics and functionality of specific T cell populations in human cancer.

We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.

We are interested in the biologic effect of gene expression changes that occur in the solid tumor. Many of these expression changes are due to the micro-physiology within the tumor. Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention. We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes.

Hemofiltration and survival in respiratory failure after bone marrow transplantation. A randomized, controlled multi – center trial. J. DiCarlo, principal investigator. Stanford University IRB #3, Protocol #78861. Pediatric Health Research Grant, Department of Pediatrics, Stanford University (03/2003 – 09/2004), and Leukemia & Lymphoma Society Translational Research Grant #6090-05 [J. DiCarlo (PI), 10/2004 – 09/2007]. Proteomic analysis of ultrafiltrate and serum in ARDS after transplantati..

My laboratory studies cancer stem cell biology and its implications for therapy. We are interested in developing a deeper molecular understanding of breast cancer and lung cancer stem cells, including identifying pathways and genes important for survival and self renewal. Additionally, we are developing methods for overcoming resistance mechanisms to radiotherapy and chemotherapy in cancer stem cells. Clinically I specialize in the treatment of lung cancer and applications of radiosurgery.

Cancer Clinical Trials Recruitment Specialist, Stanford Cancer Institute Instructor, Stanford Health Improvement Program

My research interests are focused on minimizing the impact of breast cancer from a diagnostic and therapuetic standpoint. Breast MRI is a powerful tool to facilitate the screening for and staging of breast cancer, and can be valuable adjunct to guide breast surgery. Oncoplastic surgical techniques optimize cosmesis after breast cancer surgery. Accelerated radiotherapy after lumpectomy decreases radiotherapy treatment times from 6 weeks to just 1 to 5 days.

Dr. Dodd is involved in clinical trials using endovascular coils that have a fiber coating that help heal aneurysms of the neck and can prevent an aneurysm from reforming. He uses minimally invasive endoscopic techniques to treat brain tumors. Dodd's research interests are in cerebral blood vessel reactivity and stroke.

Combined Modality Treatment of Cancer Late Effects of Treatment Genetic Effects of Cancer Rhabdomyosarcoma Hodgkins Disease Pediatric Radiation Oncolgy Pediatric Oncolgy Breast Cancer Conformal Radiotherapy/IMRT Radiotherapy for Benign Diseases

Lung Cancer, Thoracic Cancers - Surgical Oncology, Esophageal Cancer

Theories of inference applied to biostatistical data;, the bootstrap method.

Developing new mass spectrometry-based experimental and computational tools that advance the field of proteomics, and applying them to a variety of important biomedical paradigms, including cancer, aging, and stem cell biology.

Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.

We study the molecular and cellular mechanisms that control mitosis and cytokinesis in normal cells and their dysregulations that lead to aneuploidy and genomic instability in tumor cells. The current focus is on the cell cycle regulatory circuits consisting of kinases and ubiquitin ligases. In addition, we investigate the assembly, dynamics and function of mitotic structures. We use a combination of genomics, cell biology, biochemistry, and molecular genetics in mammalian cells.

My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have identified and characterized a gene (GRAIL) that seems to control T cell anergy. We have recently characterized a gene (Deaf1) that seems to play a major role in peripheral tolerance in T1D.

The overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.

Studies of the role of the vitamin D receptor in the action of 1,25-dihydroxyvitamin D, the active vitamin D hormone. Current efforts are evaluating the vitamin D receptor in breast and prostate cancer, osteoporosis and rickets.

My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.

My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits.

Clinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies, and childhood headaches.

Clinical expertise in GI cancers with research which emphasizes Phase I and II clinical trials of novel therapies but also includes translational studies including biomarkers, molecular imaging, tumor immunology and development of immunotherapeutic trials.

Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNAdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.

Population-level (community) prevention of cardiovascular disease, epidemiology and prevention of chronic diseases, tobacco use cessation research, tobacco control policy, nutrition education, blood pressure control, and lipid disorders.

Chronic disease epidemiology, particularly cancer, cardiovascular disease, adverse effects of smoking, alcohol and pharmaceuticals, evaluation of screening tests. Most of my career has been in the Kaiser Permanente Division of Research where I was Director for 7 years and am still active. I especially enjoy mentoring students and trainees at Stanford.

The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.

The goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease.

My laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the new field of molecular imaging. Methods to image gene expression in living subjects have been developed. Newer approaches to image fundamental cellular events with optical and radiolabeled probes are under active investigation. These imaging approaches are expected to have a fundamental impact in the study of cancer biology, as well as in molecular therapeutics including gene therapy

Non-Hodgkin's Lymphoma; Soft tissue sarcoma; Osteosarcoma.

Topics in the health economics of aging; health, insurance; optimal screening intervals; cost-effectiveness of, coronary surgery in the elderly; health care financing and delivery, in the United States and Japan; coronary heart disease

My research focuses on cell signaling in spermatozoa and the genetic differences among inbred strains of mice that influence successful or unsuccessful cryopreservation.

Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.

The role of nutrition in individual and societal health, with particular interests in: plant-based diets, differential response to low-carb vs. low-fat weight loss diets by insulin resistance status, chronic disease prevention, randomized controlled trials, human nutrition, community based studies, Community Based Participatory Research, sustainable food movement (animal rights and welfare, global warming, human labor practices), stealth health, nutrition policy, nutrition guidelines

My interest in translational hematopathology includes systemic mastocytosis and other myeloproliferative neoplasms, laboratory hematology, post-transplant and immunodeficiency-related lymphoproliferative disorders, and reactive lymphadenopathies. I am the pathologist on two clinical trials in treating aggressive types of systemic mastocytosis with an alternative small molecule inhibitor. I chair CAP's Hematology & Clinical Microscopy Resource Committee.

During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.

Dr. Gibbs is a board-certified radiation oncologist who specializes in the treatment of CNS tumors. Her research focuses on developing new radiation techniques to manage brain and spinal tumors in adults and children. Dr. Gibbs has gained worldwide acclaim for her expertise in Cyberknife robotic radiosurgery.

Benign Prostatic Hyperplasia- Evaluation and development of new minimally invasive techniques Endourology: developing, designing and evaluating new instruments Bladder cancer: outcomes of treatment BPH: cryotherapy and HIFU

Dr. Glaser’s interests in cancer epidemiology focus primarily on Hodgkin lymphoma, breast cancer, and Surveillance Research (the use of population-based cancer and other data to monitor cancer occurrence and related population patterns). In these areas, her work addresses cancer etiology and outcomes related to several risk factors, including EBV and HIV.

Dr. Glenn's primary interest is in molecular virology, with a strong emphasis on translating this knowledge into novel antiviral therapies. Other interests include exploitation of hepatic stem cells, engineered human liver tissues, and new biodefense antiviral strategies.

The work in the Radiological Sciences Laboratory is devoted to the advancement of imaging sciences for applications in diagnostic radiology. We collaborate closely with departmental clinicians and with others in the school of medicine, humanities, and the engineering sciences. The laboratory's activities include development of both CT and MR imaging techniques, with spiral CT.

Head and neck, interstitial Bladder, prostate, breast IORT, stereotactic, pituitary (and brain) Osteos and other sarcomas, clinical hyperthermia

As a cancer epidemiologist with a focus on surveillance research and social epidemiology, Dr. Gomez conducts research in two broad areas: 1) methodologic studies aimed at enhancing cancer registry data for studies of race/ethnicity and social determinants in cancer incidence and outcomes; and 2) studies to elucidate the underlying social factors responsible for racial/ethnic and socioeconomic health disparities, particularly those identified through surveillance data.

My laboratory is focused on studying the role of DNA methylation in prostate and bladder cancer. Certain genes and their downstream targets may be useful molecular markers for disease detection and prognostication. We are interested in utilizing methylation markers to detect abnormal changes in serum and urine. Clinical Focus: Prostate Cancer - Robotic Prostatectomy; Bladder Cancer - Robotic Cystectomy; Urologic Oncology - Prostate, Bladder, Kidney, Testicular Cancer.

Gastrointestinal Cancers Targeted therapy for Esophageal Cancer Intensity Modulated Radiation Therapy Late Effects of Radiation Sarcomas

Radio-immunotherapy. Medical Imaging Processing. Quantification for diagnosis Clinical validations

My research interests include phase I/II clinical trial evaluation of novel therapies for the following diseases: --Myelodysplastic syndromes (MDS) --Chronic myelogenous leukemia (CML) --Acute myelogenous leukemia (AML) --Myeloproliferative disorders (MPDs) including: Hypereosinophilic syndrome Systemic mastocytosis BCR-ABL-negative MPDs

We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.

I have two major research interests: the pre-leukemic bone marrow failure disorder myelodysplastic syndrome, or MDS; and the role of vascular endothelial growth factor (VEGFR) signaling in lymphoma. I have developed a novel protocol to quantitate protein expression in a cell-lineage-specific pattern in intact bone marrow using a combination of multiple immunofluorescence on tissue microarrays, semi-automated high resolution image scanning, and sophisticated image analysis.

Applications of molecular imaging in radiation therapy, development of hypoxia and radiosensitivity imaging techniques, small animal image-guided conformal radiotherapy, image processing and analysis.

Application of Micro/Nanotechnology to Biological Systems.

Regulation of hematopoiesis in myeloid malignancies with special emphasis on myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Laboratory studies utilize DNA microarrays to determine differential gene expression in MDS and AML. Transcriptomic abnormalities are also being evaluated using RNA-Seq and proteomic technologies. Translational clinical studies focus on using specific biologic targeting agents to treat these disorders.

Molecular mechanisms of pathogenesis; determinants of protective immunity; host range and tissue tropism in liver and GI tract pathogenic viruses and studies of vaccines in people.

Dr. Guardino has studied the mechanisms by which the immune system recognizes foreign substances like viruses, microorganisms and cancer and the ways the immune system becomes deregulated and attacks “self” as seen in autoimmunity. Her research identified the cellular interactions involved in immune recognition and has led to treatment strategies for cancer using immune therapies and biologic treatments.

Geoffrey Gurtner's Lab is interested in understanding the mecahnism of new blood vessel growth following injury and how pathways of tissue regeneration and fibrosis interact in wound healing.

Research in hospice and palliative care with emphases on physician education, cultural aspects of end-of-life care, and healthcare system issues.

Our current research focuses in two principal areas: 1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review. 2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.

Outcomes of radiation treatment for prostate cancer. Clinical research interests in the late effects of radiation on normal tissues and chemical modification of radiation injury. Hodgkins's disease and late effects of radiation and combined modality therapy. Radiation sensitizers. Hypoxic cell cytotoxins. Esophageal cancers. General adult and pediatric radiation therapy.

Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.

Microsurgical treatment of tumors of the brain, spinal cord, pituitary gland and skull base; Radiosurgery of tumors; Molecular biology of brain tumors.

My major research interests and activities over the next several years will focus on the development and evaluation of the objective measurement of physical activity in free-living populations using a variety of sensing devices and mobile phones for data collection and processing. Also, I will continue to direct the Stanford Heart Network with the major mission being to assist community-based CVD prevention/treatment programs implement more effective heart attack and stroke prevention programs.

Flexible statistical modelling, datamining, bioinformatics, and statistical computing.

My scholarly pursuits are primarily focused on the study of death and disease in the pediatric population. It is through this work that I am able to explore fundamental concepts of neoplasia, such as histogenesis and mutagenesis, while utilizing a variety of investigational techniques.

Most types of congenital and acquired hearing loss arise from damage to, or loss of hair cells, the sensory cells of the inner ear. Our work focuses on generating mouse and human inner ear cell types from stem cells and we are interested in signaling pathways that control hair cell (re-)generation in vitro and in vivo. In a second line of research, we are working on the identification and the molceular characterization of proteins that are important for hair cell function.

My research aims to improve our understanding of the health risks associated with exposure to tobacco marketing and provide a scientific rationale for new policies to reduce it. I also study use of media to promote and discourage adolescent tobacco use, and the impact of tobacco advertising on urge and craving to smoke.

Imaging of cardiovascular diseases with CT, magnetic resonance imaging and spectroscopy

Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibodyresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.

Mechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.

Irradiation immunosuppression; total body irradiation;, psychosocial effects of cancer treatment; treatment of lymphoma;, mycosis fungoides.

My research interests focus on nutrition and the etiology of hormonally-dependent cancers in women (most particularly breast, endometrial, and thyroid cancers). Of particular interest are the effects of phytochemicals that may reduce cancer risk, such as the isoflavones in soy foods, the lignans in whole grains, the isothiocyanates in broccoli and other cruciferous vegetables, and resveratrol in red wine and peanuts. Nutrient-gene interactions are also of interest.

My research focuses on mechanisms of malformation and morphogenesis. Specific research interests include: clinical teratology (fetal alcohol syndrome and the teratogenic effects of other drugs of abuse during pregnancy); intrauterine vascular disruption as a causative mechanism of congenital anomalies; congenital overgrowth syndromes; genetic disorders in Native Americans; the provision of genetics services to underserved populations; and innovative approaches to medical genetics education.

Our laboratory is interested in how microbial-triggered inflammation protects against pathogens and yet can result in secondary, harmful effects such as tissue fibrosis and carcinogenesis. The genitourinary tract is our model system. We are examining anti-pathogenic inflammation induced by uropathogenic E. coli. Chronic infection-mediated tissue fibrosis and carcinogenesis are being studied using models of Schistosoma haematobium.

Research interests and activities include (1) the early identification and treatment of behavioral problems, particularly in children with special health care needs; (2) emergent literacy and school readiness; and, (3) community-based mental health/educational program evaluation and outcomes measurement.

My research interests involves many aspects of Breast Cancer Imaging: contrast-enhanced MRI, MRI-guided breast biopsies, digital mammography, ultrasound, tomosynthesis, MR spectroscopy, fine-needle aspiration, large core image guideneedle biopsy, SLN biopsy, outcomes, compliance, digital mammography, CAD, optical imaging, risk assessment, molecular imaging, BIRADS and development of secure QA dashboards.

Evidence-based medicine Clinical and molecular epidemiology Human genome epidemiology Research design Reporting of research Empirical evaluation of bias in research Randomized trials Statistical methods and modeling Meta-analysis and large-scale evidence Prognosis, predictive and personalized medicine and health Sociology of science

Cell cycle and cyclin control of DNA replication .

The Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.

Dr. Jeffrey was team leader of the multidisciplinary team from the School of Medicine, School of Engineering, and Genome Technology Center that invented the MagSweeper automated technology to isolate live circulating tumor cells (CTCs) from cancer patient blood for single cell analysis. Her lab characterizes CTCs in different cancers, investigating CTC profiles and mutations as potential companion diagnostics to define individual patient response to newer biologically-based cancer therapies.

I am a clinical translational investigator with a primary interest in breast cancer biology, and the use of investigational and clinical ancillary techniques such as gene and tissue microarray analysis and immunohistochemistry in the diagnosis and prognosis of this disease. As a practicing cytopathologist, I also have an interest in improving the fine needle aspiration biopsy diagnosis of breast lesions, again using immunohistochemistry and gene expression analysis as adjuncts to cytomorphology.

Cancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development

Etiology of breast, prostate and ovarian cancer; cancer in Hispanics and African-Americans; migration and acculturation in Hispanics; modifiable lifestyle factors (vitamin D, physical activity, body size, heterocyclic amines, occupational exposures); genetic susceptibility; gene-environment interactions

Clinical research in allogeneic and autologous hematopoietic cell transplantation (HCT), more specifically, allogeneic transplantation and graft versus host disease. Exploring methods of improving prevention and treatment of GVHD as well as the long term follow-up and/or quality of life of affected patients.

Photoacoustic imaging of cancer Perfusion CT imaging of abdominal tumors

1) New therapeutic approaches for head and neck cancer, including immune stimulation possibilities (IRX-2 protocol), integration of biological modifiers, and, eventually, genetic approaches. 2) Head and neck cancer stem cells: identification, characterization, control--in conjunction with the Irv Weissman and Michael Clarke labs in the Stem Cell Institute 3) Development of innovative surgical methods at the anterior cranial base

Gynecologic malignancies; Rectal/and cancer; Breast Cancer; Hodgkin's disease; Hyperthermia; intraoperative radiation therapy; High dose rate radiation therapy; Predictive assays; Patterns of tumor spread; Health care finance.

Mark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.

Dr. Keegan's research focuses on cancer epidemiology and cancer surveillance, with primary areas of interest in genetic and modifiable factors that influence the occurrence of and survival after cancer.

- Cerebrovascular disorders - Advanced medical imaging

Assessment and treatment of cognitive deficits related to medical problems, particularly cancer. Multi-level research involving neuropsychology, neuroimaging and genetics. Measurement and enhancement of neuroplasticity mechanisms through targeted interventions.

We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.

My research is focused on the development and evaluation of cigarette smoking prevention and cessation therapies and obesity prevention treatments for children, adolescents and adults.

Clinical research in cutaneous lymphomas, especially, mycosis fungoides; studies of prognostic factors, long-term survival results, and effects of therapies. Collaborative research with Departments of Pathology and Oncology in basic mechanisms of cutaneous lymphomas. Clinical trials of new investigative therapies for various dermatologic conditions or clinical trials of known therapies for new indications.

We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.

My interests include the application of behavioral theory and social ecological approaches to achieve large scale changes impacting chronic disease prevention and control; expanding the reach and translation of evidence-based interventions through state-of-the-art technologies; exploring social and physical environmental influences on health; applying community participatory research perspectives to address health disparities; and policy-level approaches to health promotion/disease prevention.

Our interests include 1) study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2) use of radiation as an immune modulator for optimization of transplant regimens, 3) the role of radiation in tumor vaccine strategies, 4) study of new radiosensitizers and radioprotectors, and 5) discovery of new targeted therapies for the treatment of solid tumors.

The focus of my laboratory is to understand the role of hypoxia and the tumor microenvironment on malignant progression. My clinical area of interest is in the application of chemoradiotherapy and stereotactic body radiotherapy (SBRT) for GI malignancies.

Dr. Koopman's research is focused in three primary areas: 1) Investigating factors associated with neuropsychiatric and other symptoms and quality of life in persons with serious illness. 2) Evaluating psychosocial and other kinds of interventions to improve health and quality of life among persons who are living with or are survivors of serious illness. 3) Examining factors associated with health behaviors (e.g., sleep, sexuality, and substance abuse) among the medically ill.

I am interested in the methodology pertinent to dealing with research problems where biological and behavioral interests meet. These interests have been applied not only in psychiatric research, but in those areas of Cardiology, Pediatrics and other fields of medicine in which behavioral research is becoming ever more salient.

- Lung development and stem cells - Neural control of breathing - Lung diseases including lung cancer - New genetic model organisms for medicine

Mechanisms and therapies for infection, cancer, autoimmunity and transplantation.

We explore angiogenesis, cancer genomics, intestinal stem cells, and hepatic glucose metabolism. Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. Intestinal stem cell projects use primary intestinal culture and mouse genetics to study injury-inducible vs homeostatic stem cells. We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery.

Breast and gynecologic cancer genetics, epidemiology, prevention, and outcomes.

Gastrointestinal cancer prevention and risk management. Risk stratification. Cost-effectiveness analysis. Health services research.

Research interests include clinical trial design, cancer biostatistics, survival analysis, adaptation and sequential experimentation, change-point detection and segmentation, stochastic optimization, time series and inference on stochastic processes, hidden Markov models and genomic applications.

haploidentical transplantation, follicular lymphoma, adoptive immunotherapy,supportive care

Biostatistics, clinical trials, longitudinal studies, casual inference from observational studies, genetic tissue banking, informed consent. Trial designs for dynamic (adaptive) treatment regimes, psychiatric research, cancer.

My laboratory research interest focuses on the identification of biomarkers for prognosis in patients with head & neck or lung cancers. I am also conducting a number of clinical trials specifically in patients with head & neck cancers.

My current research interests are to study the biology of breast cancer stem cells (CSCs) and the functional role of genes involved in CSCs proliferation and self-renewal. Since CSCs are believed to be responsible for recurrent and metastatic breast cancer, the ultimate goal is to develope targeted therapies to specifically kill the CSCs subpopulation. Identification of genes involved in CSCs functions may lead to novel CSC targeted therapy.

Understanding the biology of cancer-T cell interactions.

Our research aims to improve the global quality of care for patients with Urologic cancer with a particular focus on kidney cancer. We are evaluating the comparative effectiveness of various kidney cancer surgeries and their impact on chronic kidney disease and its downstream effects. We are investigating nanofluidic proteomic assays to diagnose kidney cancer and signatures of response to therapy. We are applying epidemiology, bioinformatics, and health services methods to urologic conditions.

Our long term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on thrombin, the key enzyme in the blood clotting cascade.Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders.

Molecular Imaging Instrumentation Laboratory Our research interests involve the development of novel instrumentation and software algorithms for in vivo imaging of cellular and molecular signatures of disease in humans and small laboratory animal subjects.

Clinical Interests: lymphoma. Research Interests: Immunology and molecular biology of lymphoid malignancy; molecular vaccines for cancer.

Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria.

My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.

My laboratory is engaged in translational research to develop new in vitro and in vivo diagnostic tools for diseases of the urinary tract based on micro- and nanotechnology. We are developing an integrated biosensor platform optimized for point-of-care urinary diagnostics, particularly for urinary tract infections and bladder cancer. We are also developing in vivo imaging tools for applications in endoscopic and minimally invasive surgery.

1) Design of phase I/II trials for the treatment of Multiple Myeloma and Amyloidosis 2) Conduct of clinical trials to improve the treatment of patients with acute lymphoblastic leukemia (ALL) 3) Outcomes research using clinical databases for patients with Multiple Myeloma and Amyloidosis 4) Characterization of the molecular mechanism of MLL-induced acute leukemia

Hematology/Oncology, treatment of sarcomas of bone and soft tissue, biology of acute lymphoblastic leukemias, treatment of non-Hodgkin's lymphoma and Hodgkin's disease.

Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.

Gynecological, breast and gastrointestinal pathology with major emphasis on ovarian cancer and ovarian tumors of low malignant potential. Pathology of familial and hereditary breast-ovarian-GI cancer.

We have six main areas of current interest: 1) Cranial Suture Developmental Biology, 2)Distraction Osteogenesis, 3) Cleft Palate and Lip Biology, 4)Keloid and Hypertrophic Scar Biology, 5) Scarless Fetal Wound Healing, 6) Novel Gene and Stem Cell Therapeutic Approaches.

My clinical specialties are radiation treatment of lung and head & neck cancers, and I serve as the Tthoracic Radiation Oncology Program Leader. My research interests include 4-D multimodality imaging of tumor and organ motion using CT, PET, and MR; novel functional/metabolic imaging of tumor hypoxia, normal tissue inflammation, and lymphatic drainage; high-precision image-guided radiation therapy including 4-D IMRT, dynamic arc therapy, and stereotactic ablative radiotherapy (SABR).

Community based psycoeducational intervention studies of disease self management for people with chronic diseases. arthritis, lung diseases, heart disease AIDs, low back pain and diabetes. Programs and studies in Spanish and English. Interventions are in small groups, mailed or on the Internet.

Pancreatic and esophageal cancers are common and deadly cancers of the gastrointestinal tract. Our laboratory is currently focused on the characterization of genes important in tumor development and growth. Such genes will potentially serve as therapeutic targets. An additional focus of the laboratory is the development of diagnostic assays for the early detection of pancreatic and esophageal disease.

My research in the field of biomedical informatics over the past 30 years has focused on the development of novel uses of information technology and computer science to improve human health. My current interests include the Electronic Health Record (EHR), biomedical knowledge representation, Internet applications in healthcare, clinical data warehouses, clinical data and text mining, academic social networking and the use of information technology to support clinical and translational research.

Dr. Lowsky's research is focused on understanding the role of regulatory T cells in the prevention of GVHD and in promoting immune tolerance following organ transplantation.

Functional neuroimaging of pain. Imaging of cognitive and affective dimensions of pain, neural plasticity contributing to chronic pain and effects of treatment. Effects of membrane stabilizing medications on neuropathic pain. Chronic pain outcomes tools development and measurement.

Germ cell tumors and bone sarcomas.

The Marinkovich lab studies the function of epithelial extracellular matrix molecules, including integrins, collagens and laminins in epithelial development and carcinoma progression. We apply our discoveries in this area towards development of molecular therapies for carcinomas, hair disease and inherited epithelial adhesive disorders.

EBV B cell lymphomas; pathways of immune evasion in the growth and survival of EBV B cell lymphomas; mechanisms of graft rejection and tolerance induction; stem cell and solid organ transplantation.

My clinical activities combine the development of novel therapeutic modalities, translational research activities and epidemiological study of acute leukemia. My special focus is on the development of better, patient tailored therapies for young and elderly patients with acute leukemia.

Investigates the targets of immune responses after human allogeneic stem cell transplantation. BMT patients develop antibodies against minor histocompatibility antigens (mHA) that are associated with chronic graft-v-host disease (cGVHD) and disease remission. Current projects: investigate Ab anti-tumor mechanism, high-throughput serologic identification of novel mHA in the development of GVHD and prevention of disease relapse, and clinical trials of B cell therapeutics for cGVHD.

Dr. Mindea’s primary clinical interests include minimally invasive spinal surgery techniques and the management of primary and metastatic spinal tumors (cyberknife/ surgical oncology). His research interests include the development medical devices and cutting-edge technologies for the treatment of spinal disorders and tumors.

Beverly Mitchell's research relates to the development of new therapies for hematologic malignancies, including leukemias and myelodsyplastic syndromes. She is interested in preclinical proof of principle studies on mechanisms inducing cell death and on metabolic targets involving nucleic acid biosynthesis in malignant cells. She is also interested in the translation of these studies into clinical trials.

Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.

MR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods

We study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.

My research seeks to advance the clinical and basic sciences in radiology, while improving our understanding of biology and the manifestations of disease, by pioneering methods in the information sciences that integrate imaging, clinical and molecular data. A current focus is on content-based radiological image retrieval and integration of imaging features with clinical and molecular data for diagnostic, prognostic, and therapy planning decision support.

My research interests focus on the identification and characterization of markers of diagnostic and prognostic importance in hematolymphoid neoplasia.

Applying new technologies to the diagnosis, characterization, and treatment of non-small cell lung cancer.

Our labaratory focuses on the study of immune recognition by T and NK cells with special emphasis on graft vs host disease and graft vs tumor reactions. We utilize both murine and human systems in an effort to enhance graft vs tumor reactions while controlling graft vs host disease. We have developed bioluminescence models in collaboration with the Contag laboratory to study the trafficking of immune effector cells with a special emphasis on NK, T and regulatory T cells.

Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.

Dr. Nguyen is interested in cancer prevention and control in ethnic and socio-economic underserved communities and health disparities.

Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens as well as understanding normal immune system function. Using advanced flow cytometric techniques such as Mass Cytometry and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.

Interleukin-12 is a Th1 cytokine. It is important in the cell mediated immune response. We are investigating its role as an anti-tumor cytokine to augment the immune response against cancer. We are planning a human trial.

Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.

Dr. O’Malley is interested in disease surveillance, breast(both males and females), ovarian, colon and lung cancers. She has focused much of her research on cancer outcomes, particularly the interplay between comorbidity, treatment and survival.

Evaluating factors associated with racial disparities in prostate and breast cancer diagnosis, progression and survival. Evaluating genetic factors and gene/environment interactions involved in prostate and breast cancer incidence, progression and survival. Assessing quality of life and survivorship issues two or more years after diagnosis. Providing information and community-based solutions to improve public health.

My research is in statistics and their applications to medicine and biology. Many efforts have concerned tree-structured algorithms for classification, regression, survival analysis, and clustering.

Hedgehog signaling has been implicated in the induction or maintenance of up to 25% of human tumors and a variety of birth defects. Our lab studies Sonic hedgehog (Shh) signaling in normal hair follicle development and in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin. We are interested in how the local stromal environment regulates hedgehog signaling and hair follicle or tumor growth and invasion and developing novel targets for therapy.

My research uses decision analysis, cost-effectiveness analysis, and meta-analysis to evaluate clinical and health policy problems.

Imaging informatics, information integration, spatiotemporal modeling, image analysis, quantitation for molecular imaging, imaging simulation, statistical methods for imaging evaluation, and visualization with application in cancer imaging.

For most areas of the mammalian brain, the production of new nerve cells or neurons is restricted to fetal development. However, there are exceptions to the rule. Some areas of the brain continue to make new neurons throughout life. This neurogenesis is mediated by neural stem cells and our research goals are to understand how stem cell activity and fate are controlled. Ultimately, we hope to harness the nascent potential of stem cells to treat neurological injury and disease.

The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.

The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity. B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor. We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance. We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.

I am interested in the long-term consequences of chronic interactions between the human host and the microbial world. Recently, we have focused most heavily on Helicobacter pylori, tuberculosis and helminth infections. I also remain strongly interested in diarrheal diseases, particularly in the developing world, and in sanitation and hygiene.

My current research interests lie in the area of magnetic resonance and MR-guided high intensity focused ultrasound for minimally invasive cancer therapy and neuromodulation.

My research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.

Broadly, Dr. Pelc is interested in the physics, engineering and mathematics of medical imaging, especially computed tomography, digital x-ray imaging, magnetic resonance imaging, and hybrid multimodality systems. His current research is concentrated in the development of computed tomography systems with higher image quality and dose efficiency, in the characterization of system performance, and in the development and validation of new clinical applications.

The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events. We also study how cells acquire cholesterol from the diet and from LDL.

Clinical Interests: general oncology, head and neck cancer Research Interests: chemoprevention trials and combined modality approaches to head and neck cancer

The Pitteri laboratory is focused on the discovery and validation of proteins that can be used as molecular indicators of risk, diagnosis, progression, and recurrence of cancer. Proteomic technologies, predominantly mass spectrometry, are used to identify proteins in the blood that are differentially regulated and/or post-translationally modified with disease state. Using human plasma samples, tumor tissue, cancer cell lines, and genetically engineered mouse models, the origins of these prote..

My research program focuses on computational modeling of cancer biology and cancer outcomes. My laboratory develops stochastic models of the natural history of cancer based on clinical research data. We estimate population-level outcomes under differing screening and treatment interventions. We also analyze genomic and proteomic cancer data in order to identify molecular networks that are perturbed in cancer initiation and progression and relate these perturbations to patient outcomes.

Our laboratory uses genomic approaches to explore patterns of gene expression and gene copy number alteration in human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies.

Single molecule biophysics, precision force measurement, micro and nano fabrication with soft materials, integrated microfluidics and large scale biological automation.

Multimodality fusion imaging with PET, CT, and MRI for oncology. Translational research bringing new radiotracers to clinical use. Cardiovascular multimodality PET/CT imaging.

Clinical effectiveness of acupuncture in medical conditions, use of acupuncture in perioperative settings to reduce opiate and antiemetic use, use of acupuncture in pregnancy for the treatment of nausea, vomiting and other conditions, use of acupuncture in the treatment of the side effects in cancer patients.

Our laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.

The Reijo Pera Laboratory is focused on pluripotent stem cells and regenerative medicine with an emphasis on understanding key cell fate decisions in early human development. In particular, we examine early events such as the generation of pluripotent stem cells, somatic and germ cell lineages and pathologies that arise in development.

My investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.

Dr. Reynolds directs the environmental research group at CPIC, with primary research interests in the environmental influences in the etiology of breast cancer and cancers in children. She has also conducted research in the role of second hand smoking in the development of cancers of the lung, breast and colon.

my primary research focuses on the quality of care in hospitals where minorities get cancer treatment and the impact on cancer outcomes and disparities

Dr. Robinson focuses on "solution-oriented" research, developing and evaluating effective health promotion and disease prevention interventions for children and adolescents. His research is mostly experimental, conducting school-, family- and community-based randomized controlled trials to test theory-driven behavioral, social and environmental interventions to prevent obesity, improve nutrition, increase physical activity, reduce smoking, and study the effects of children's television use.

My clinical research includes studies on risk factor modification in atherosclerosis and coronary artery disease; clinical trials involving medical therapies for peripheral arterial insufficiency; coronary angiogenesis; therapy of lymphedema; atherand photodynamic therapy in atherosclerosis.