Cancer Institute A national cancer institute
designated cancer center
Profile http://med.stanford.edu/profiles/cancer/researcher/Annelise_Barron/
Email this profile
Portrait View Larger

Annelise E. Barron

Academic Appointments

  • Associate Professor of Bioengineering

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email
    Alternate Contact
    Raul Felipa Finance Administrator, Stanford Dept. of Bioengineering Tel Work 650-725-7665

Bio

Current research: Molecular and cellular biophysics of human innate immunity, with a focus on the pleiotropic roles of host defense peptides and amyloidogenic peptides in human health and disease.

Previous research: Design, synthesis, and biophysical studies of sequence-controlled, biomimetic oligomers (synthetic peptide mimics) with helical structures, for biomedical and biomaterial applications (mimicry of lung surfactant proteins and antimicrobial peptides). Also in previous work: design and synthesis of novel polymeric materials and strategies for capillary and microchip electrophoresis (DNA sequencing and genotyping); polymer-biomolecule conjugates.

Academic Appointments

Administrative Appointments

  • Associate Chair for Graduate Studies, Department of Bioengineering (2010 - 2015)

Honors and Awards

  • Nanobio Scholar, Virginia Tech (2011)
  • W.M. Keck Associate Professor of Bioengineering, Stanford University (2007-present)
  • Thiele Lecturer in Chemical Engineering, University of Notre Dame (2005)
  • Camille Dreyfus Teacher-Scholar Award, Camille and Henry Dreyfus Foundation (2002)
  • DuPont Young Professor Award, DuPont, Inc. (2002)
  • Presidential Early Career Award for Scientists and Engineers, NIH/NHGRI (1999)
View All 19honors and awards of Annelise Barron

Professional Education

Postdoc: UCSF/Chiron Corporation, Biomimetic & Bioorganic Chemistry (1997)
Postdoc: Soane BioSciences/ACLARA Biosciences Inc., Molecular Biotechnology (1996)
Ph.D.: Univ. of California, Berkeley, Chemical Engineering (1995)
B.S.: Univ. of Washington, Seattle, Chemical Engineering (1990)

Research & Scholarship

Current Research and Scholarly Interests

According to our recent findings, dysfunctional innate immune responses in humans and other mammals involving stress-related, dynamic imbalances between particular, potently cytotoxic host defense peptides under study in our lab, and pro-amyloid / fibrillogenic peptides including ABeta and IAPP, may play a role in the poorly understood etiology of chronic / progressive plaque diseases, including psoriasis, lupus erythematosus, diabetes type II melittus, atherosclerosis, and particularly, Alzheimer's Disease.

The latter disease, Alzheimer's, is in need of a major breakthrough in fundamental understanding, more than almost any human disease currently under study. Virtually all of the clinical trials initiated by big pharma have failed--there is no current treatment.

We are testing novel mechanistic hypotheses of Alzheimer's etiology, based on recent, unique molecular biophysical observations of pro-amyloid and innate immune peptides.

Increasing numbers of epidemiological and co-morbidity studies are indicating that these multiple, progressive degenerative diseases, all involving plaque deposition in various body compartments, are linked. We are seeking, therefore, to uncover the molecular biophysical bases for this emerging linkage. For instance, many researchers have begun to refer to Alzheimer's Disease as "Diabetes Melittus Type III".

(Note: Succinct, exemplary summaries of these fascinating epidemiological / comorbidity linkages can be found, for instance, in the following papers: "The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity", 2011 John Wiley & Sons A/S, Experimental Dermatology, 20, 303–307; "Circle of Willis atherosclerosis: association with Alzheimer’s disease, neuritic plaques and neurofibrillary tangles", Acta Neuropathol (2007) 113:13–21, DOI 10.1007/s00401-006-0136-y; "Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis", Arch Dermatol Res (2006) 298:321–328, DOI 10.1007/s00403-006-0703-z; "Association of Alzheimer disease pathology with abnormal lipid metabolism", Neurology 2011;77;1068, DOI 10.1212/WNL.0b013e31822e145d)

Teaching

Courses

2013-14

Prior Year Coursescourses of Annelise Barron

Publications

Publications

Publication tag cloud

Publication Topics

View All 148

Stanford Medicine Resources:

Footer Links: