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Howard Y. Chang

Academic Appointments

  • Professor of Dermatology

Key Documents

Contact Information

  • Clinical Offices
    Dermatology Clinic - North Campus 450 Broadway St Pavilion B Redwood City, CA 94063
    Tel Work (650) 723-6316 Fax (650) 721-3476
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  • Academic Offices
    Alternate Contact
    Daniel Braslavsky Administrative Associate Tel Work 650-725-7022
    Not for medical emergencies or patient use
Office Location

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thumb Howard Y. Chang
450 Broadway St, Redwood City, CA 94063

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Insurance Instructions

After you schedule your appointment, a representative from Stanford Hospital & Clinics (SHC) will contact you to collect demographic and insurance information. We will verify that SHC accepts your insurance and collect any required authorizations. If we are unable to contact you before your appointment, please call the clinic directly to provide your insurance information. The clinic phone number will be included in your email appointment confirmation.

If you would like to verify that your insurance is accepted at SHC prior to your appointment, please contact your insurance provider directly. If you have an HMO insurance plan, please obtain from your insurance provider, prior to your appointment, a written authorization to be seen at SHC. If your insurance benefits do not cover your visit, you will be asked to sign a Patient Acceptance of Financial Responsibility form upon arrival and submit payment upon receipt of your bill.

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Professional Overview

Clinical Focus

  • Cancer> Cutaneous (Dermatologic) Oncology
  • Dermatology
  • General Dermatology

Administrative Appointments

  • Director, NIH Center of Excellence in Genomic Science: Center for Personal Dynamic Regulome (2014 - 2019)

Honors and Awards

  • Salvador E. Luria Lecture, Massachusetts Institute of Technology (2012)
  • Montagna Lecture, Society for Investigative Dermatology (2012)
  • Alfred Marchionini Research Prize, Alfred Marchionini Foundation (2011)
  • CE.R.I.E.S. Award, Chanel Research and Technology (2010)
  • Early Career Scientist, Howard Hughes Medical Institute (2009-2015)
  • Senior Scholar Award in Aging, Ellison Medical Foundation (2009)
View All 14honors and awards of Howard Chang

Boards, Advisory Committees, Professional Organizations

  • Editorial Board, Molecular Cell (2014 - present)

Professional Education

Fellowship: Stanford University School of Medicine CA (2004)
Board Certification: Dermatology, American Board of Dermatology (2004)
Residency: Stanford University School of Medicine CA (2003)
Internship: Santa Clara Valley Medical Center CA (2001)
Medical Education: Harvard Medical School MA (2000)
Ph.D.: MIT, Biology (1998)
View All 7

Courses

2013-14

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

The same genetic blueprint gives rise to thousands of cell types that make up the human body. Intricate mechanisms govern the choice to make skin, heart, or brain cells. These different cell types must be correctly arranged in spatial patterns to make functioning tissues and organs. In many organisms with continual turnover of cells, the genome faces the additional challenge of ensuring the faithful transmission of information throughout a lifetime—over decades in the case of humans. Thus, how one genome encodes thousands of patterns in space and time is of central importance to biology and medicine. Inappropriate activation of genes can give rise to birth defects, premature aging, or cancer, among many other diseases. Restoration of proper organ function often requires restoring homeostatic gene regulation.

Long Noncoding RNAs and Positional Identity
As a practicing dermatologist, I am fascinated by what makes human skin from different parts of the body different, a fact that guides the diagnosis and treatment of many skin diseases. Why do long hairs grow on the scalp but not on our palms or soles? How do cells know where they are located in the body, and how do they remember this information?

We discovered that one class of skin cells, the fibroblasts, encode the positional identity of skin via specific markings on their chromatin, the DNA-protein complex where genes reside. Based on the chromatin configurations of specific genes, most notably the HOX genes, fibroblasts differentially activate hundreds of genes based on their the cell’s location along three anatomic axes—anterior-posterior (head to tail), proximal-distal (close or far away from the trunk), and dermal-nondermal (surface or internal organ). This in effect creates a global positioning system for all cells to navigate.

These studies also revealed a surprising abundance of long intergenic long noncoding RNAs (also known as lincRNAs, a newly recognized type of genes that do not code forencode proteins) that are involved in programming chromatin states. We are particularly fascinated by HOTAIR, the first known lincRNA that can regulate the chromatin state of genes on distantly located chromosomes. We now appreciate that the genome is pervasively transcribed to give rise to thousands of lincRNAs, which are likely to play key roles in the gene regulation of diverse biological states and disease. We are interested in understanding how lincRNAs control gene activity, and in deciphering the rules that will allow the functions of thousands of lincRNAs to be predicted and studied.

Large-Scale Gene Regulatory Programs in Cancer Metastasis and Self-Renewal
In contrast to the orderly acquisition of positional identity, cancer progression is characterized by abrogation of normal positional boundaries, especially in metastasis, which is the leading cause of cancer death. We and many others have previously identified gene expression signatures (GES ), composed of dozens to hundreds of genes, that distinguish indolent human cancers from those prone to metastasis; these signatures can provide improved prognostic prediction for cancer patients. Furthermore, we have developed methods to pinpoint master regulators of GES—singular control points that can toggle the activity of the entire genetic program. This allows complex gene programs observed in human cancers to be easily recapitulated in the laboratory as models for drug development. This has enabled the creation of faithful laboratory models of human cancer types, identified specific drugs that can target these cancers, and revealed the hierarchy of transcriptional programs involved in the generation of cancer stem cells—the cells that continually repopulate a tumor or its metastases.

Publications

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Publication Topics

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