Cancer Institute A national cancer institute
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Anne Brunet

Academic Appointments

  • Professor of Genetics

Key Documents

Bio

Academic Appointments

Honors and Awards

  • Senior Scholar Award, Ellison Medical Foundation (2009-2013)
  • Junior Investigator Award, California Institute for Regenerative Medicine (CIRM) (2008-2013)
  • Innovation in Aging Research Award, Pfizer/American Association for Aging Research (2005-2007)
  • Klingenstein Fellow, The Esther A. & Joseph Klingenstein Fund (2005-2008)
  • Alfred P. Sloan Fellow, Sloan Foundation (2006-2008)
  • Glenn Award, The Glenn Foundation for Medical Research (2007)

Professional Education

B.Sc.: Ecole Normale Superieure, Paris, Molecular Biology (1992)
Ph.D.: University of Nice, France, Cell Biology (1997)
Postdoctoral fellow: Harvard Medical School, Neuroscience (2003)

Research & Scholarship

Current Research and Scholarly Interests

The overarching goal of our lab is to understand the genetic mechanisms of aging and longevity. Aging is a highly plastic process regulated by a combination of genetic and environmental factors.

We have a long-standing interest in the genetic pathway that connects insulin to FOXO transcription factors, a central pathway to regulate lifespan from worms to humans. We use a combination of genetic, molecular, and cellular approaches to analyze the regulation and importance of FOXO transcription factors, and more generally 'longevity genes' in mammals. We are particularly interested in the role of longevity genes in the maintenance of the pool of adult neural stem cells and intact cognitive function during aging. We also use ultra-high throughput sequencing technologies to study epigenetic changes and transcriptional networks during aging.

In parallel, our goal is to identify novel ‘longevity genes’ using short-lived animal models. Our lab uses unbiased approaches in the nematode C. elegans to identify novel pathways that control organismal longevity, particularly in response to dietary restriction. We are particularly interested in the role of chromatin modifiers in the regulation of lifespan and metabolism.

Finally, we are developing the extremely short-lived African killifish N. furzeri as a new vertebrate model for aging studies. We are taking advantage of this fish to explore the genetic architecture of longevity in vertebrates.

Teaching

Courses

2014-15

Prior Year Coursescourses of Anne Brunet

Publications

Publications

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Publication Topics

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