Cancer Institute A national cancer institute
designated cancer center
Profile http://med.stanford.edu/profiles/cancer/researcher/Roeland_Nusse/
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Roeland Nusse

Academic Appointments

  • Virginia and Daniel K. Ludwig Professor in Cancer Research

Key Documents

Contact Information

  • Academic Offices
    Personal Information
    Email Tel (650) 723-7769

Bio

Academic Appointments

Administrative Appointments

  • Chair, Developmental Biology (2007 - 2012)

Honors and Awards

  • Member, US National Academy of Sciences (2010)
  • Member, American Academy of Arts and Sciences (2001)
  • Member, Royal Dutch Academy of Sciences (1997)
  • Member, European Molecular Biology Organization (1988)

Research & Scholarship

Current Research and Scholarly Interests

Our laboratory is interested in the growth, development and integrity of animal tissues. We study multiple different organs, trying to identify common principles, and we extend these investigations to cancer and injury repair. In most organs, different cell types are generated by stem cells - cells that also make copies of themselves and thereby maintain the tissue. An optimal balance between the number of stem and differentiated cells is essential for the proper function of the organs. Locally-acting signals are important to maintain this balance in a spatially-organized manner and these signals are key to understanding the regulation of growth.

A common theme linking our work together are Wnt signals. Work from many laboratories, including our own, has shown that Wnt proteins are essential for the control over stem cells. How this is achieved is far from clear and is the subject of studies in the lab, both in vivo and in cell culture. In vivo, a particular question we address is how physiological changes, such as those occurring during hormonal stimuli, injury or programmed tissue degeneration have an impact on the self-renewal signals and on stem cell biology.

Teaching

Courses

2014-15

Prior Year Coursescourses of Roeland Nusse

Postdoctoral Advisees

Katharine BrownHinako Miyamichi

Publications

Publications

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