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George Triadafilopoulos

Academic Appointments

Key Documents

Contact Information

  • Clinical Offices
    Silicon Valley Gastroenterology 2490 Hospital Dr Ste 211 Mountain View, CA 94040
    Tel Work (650) 988-7530 Fax (650) 396-5566
  • Academic Offices
    Personal Information
    Email Tel (650) 988-7488
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Gastroenterology

Honors and Awards

  • Distinguished Service Award, American Society for Gastrointestinal Endoscopy (2009)

Professional Education

Fellowship: Boston University School of Medicine MA (1985)
Internship: Wayne State University School of Medicine MI (1981)
Residency: Wayne State University School of Medicine MI (1982)
Board Certification: Gastroenterology, American Board of Internal Medicine (1985)
Board Certification: Internal Medicine, American Board of Internal Medicine (1983)
Residency: Sinai Hospital - Detroit MI (1983)
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Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

My primary research interest concerns factors involved in the pathogenesis of gastro-esophageal reflux disease (GERD) and its complications, such as Barrett's esophagus. Over the past decade I have explored the potential role of COX-2 expression and activity, prostaglandin and leukotriene production and cell proliferation in inducing and amplifying symptoms and disease evolution. Ongoing studies in the area of Barrett's metaplasia involve characterizing unique cell surface or intracellular molecular changes that occur in the early stages of metaplastic transformation and identification of environmental factors that predispose to esophageal metaplasia. In particular, I am interested in the role of acid and bile reflux in modifying cellular alterations and contributing to dysplasia and neoplasia. Furthermore, in clinical studies, I am investigating the role of 24-hour dual pH monitoring in the management of patients with reflux-like dyspepsia, esophagitis, and BarrettÂ’s esophagus, and particularly the role of intensive proton pump inhibitor therapy in chemoprevention against esophageal adenocarcinoma. I have a very active clinical base of patients with BarrettÂ’s esophagus in which advanced diagnostic (narrow band imaging, in vivo confocal microscopy, chromo-endoscopy) as well as therapeutic (endoscopic mucosal resection, radiofrequency ablation) modalities are prospectively explored and validated.


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Publication Topics

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