Ann M. Arvin
Academic Appointments
- Professor, Pediatrics - Infectious Diseases
- Member, Stanford Cancer Institute
- Member, Child Health Research Institute
- Professor, Microbiology & Immunology
Key Documents
Contact Information
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Clinical Offices
Pediatric Infectious Disease 730 Welch Rd 2nd Floor MC 5884 Palo Alto, CA 94304 Tel Work (650) 736-7642 Fax (650) 725-8040Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 498-6227Alternate Contact Nancy Wilkening Administrative Assistant Email Tel Work 650-498-6227Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Infectious Diseases, Pediatric
- Pediatric Infectious Disease
Administrative Appointments
- Vice Provost and Dean of Research, Stanford University (2006 - present)
- Associate Dean of Research, Stanford University (2001 - 2006)
Honors and Awards
- Elected Member, American Academy of Arts and Sciences (2012)
- Distinguished Graduate Award, University of Pennsylvania School of Medicine (2010)
- Elected member, American Association for the Advancement of Science (2009)
- Director's Advisory Council, National Institute of Allergy and Infectious Diseases (2007-2011)
- Albion Walter Hewlett Award, Stanford University School of Medicine (2004)
- Elected member, Institute of Medicine of the National Academy of Science (2003)
Professional Education
| Internship: | UCSF Medical Center, CA USA (1973) |
| Residency: | UCSF Medical Center CA (1975) |
| Board Certification: | General Pediatrics, American Board of Pediatrics (1978) |
| Fellowship: | Stanford University Medical Center CA (1978) |
| Medical Education: | University of Pennsylvania PA (1972) |
| M.D.: | University of Pennsylvania School of Medicine, Medicine (1972) |
Graduate & Fellowship Program Affiliations
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
Varicella-zoster virus (VZV) causes varicella (chickenpox) and zoster (shingles). Our laboratory investigates the molecular virology of VZV, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in SCID mouse models of VZV infection in vivo. Aspects of VZV tropism are investigated using SCID mice that have human skin, T cell and dorsal root ganglion xenografts and VZV recombinant viruses that have targeted mutations of viral promoters, open reading frames and non-coding regions. The consequences of targeted mutations in the VZV genome reveal functions that are important for VZV pathogenesis and that counteract intrinsic cellular regulation of VZV replication. These studies provide information relevant for developing new genetically engineered vaccines to reduce the disease burden of VZV infections.
Publications
- An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis. Proc Natl Acad Sci U S A. 2013; (5): 1911-6
- Herpes simplex virus 1 tropism for human sensory ganglion neurons in the severe combined immunodeficiency mouse model of neuropathogenesis. J Virol. 2013; (5): 2791-802
- 3D reconstruction of VZV infected cell nuclei and PML nuclear cages by serial section array scanning electron microscopy and electron tomography. PLoS Pathog. 2012; (6): e1002740
- Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. Proc Natl Acad Sci U S A. 2012; (2): 600-5
- Disruption of PML nuclear bodies is mediated by ORF61 SUMO-interacting motifs and required for varicella-zoster virus pathogenesis in skin. PLoS Pathog. 2011; (8): e1002157
- Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. PLoS Pathog. 2011; (2): e1001266
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