Lawrence Leung
Academic Appointments
- Professor, Medicine - Hematology
- Member, Stanford Cancer Institute
Key Documents
Contact Information
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Clinical Offices
Hematology Clinic 875 Blake Wilbur Dr Clinic C MC 5820 Stanford, CA 94305 Tel Work (650) 498-6000 Fax (650) 724-5203Hematology Clinic 875 Blake Wilbur Dr Clinic C MC 5820 Stanford, CA 94305 Tel Work (650) 498-6000 Fax (650) 724-5203
- Academic Offices
Personal Information Email Tel (650) 725-4036Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cancer> Hematology
- Hematology
Administrative Appointments
- Chief of Staff, VA Palo Alto Health Care System (2006 - present)
- Senior Associate Dean for Veterans Affairs, School of Medicine (2006 - present)
Professional Education
| Residency: | New York Hospital NY (1978) |
| Medical Education: | Columbia University, NY USA (1975) |
| Board Certification: | Hematology, American Board of Internal Medicine (1980) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (1978) |
| Board Certification: | Medical Oncology, American Board of Internal Medicine (1981) |
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
Our long-term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on thrombin, the key enzyme in the blood clotting cascade. Using a library of thrombin mutants generated by site-directed mutagenesis, we have mapped the critical functional sites on thrombin for its interactions with its diverse substrates. We are studying a thrombin-activatable carboxypeptidase that plays a key role in the physiologic regulation of thrombinÂ’'s pro-thrombotic and pro-inflammatory properties. Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders.
Publications
- Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem. 2013; (5): 3097-111
- Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma. J Biol Chem. 2011; (45): 39520-7
- Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J Clin Invest. 2011; (9): 3517-27
- Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma. J Biol Chem. 2011; (45): 39510-9
- Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. Arterioscler Thromb Vasc Biol. 2010; (7): 1363-70
- Heparin-induced thrombosis without thrombocytopenia. J Thorac Cardiovasc Surg. 2010; (2): e6-7
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