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Gilbert Chu

Academic Appointments

  • Professor of Medicine (Oncology) and of Biochemistry

Key Documents

Contact Information

  • Clinical Offices
    Medical Oncology 875 Blake Wilbur Dr Clinic F MC 5820 Stanford, CA 94305
    Tel Work (650) 498-6000 Fax (650) 736-4167
  • Academic Offices
    Personal Information
    Email
    Alternate Contact
    Leslie Quiroz administrative assistant Tel Work 650-725-6454
    Not for medical emergencies or patient use

Bio

Clinical Focus

  • Cancer> GI Oncology
  • Oncology

Academic Appointments

Honors and Awards

  • Phi Beta Kappa, Princeton University (1967)
  • Giulio Racah Prize, International School of Subnuclear Physics, Erice, Italy (1973)
  • Henry Asbury Christian Award for Notable Scholarship, Harvard Medical School (1980)
  • Rita Allen Award, Rita Allen Foundation (1988-1993)
  • Clinical Scientist Award for Translational Research, Burroughs-Wellcome Fund (1997-2002)
  • Kaiser Award for Preclinical Teaching, Stanford University (2003, 2007)
View All 7honors and awards of Gilbert Chu

Boards, Advisory Committees, Professional Organizations

  • Member, American Physical Society (1967 - present)
  • Member, Sigma Xi (1975 - present)
  • Member, American Association for the Advancement of Science (1987 - present)
  • Member, Environmental Mutagenesis and Genomics Society (1997 - present)
  • Member, American Society for Clinical Oncologists (1997 - present)
  • Member, Society for Chinese Bioscientists in America (1999 - present)

Professional Education

Fellowship: Stanford University School of Medicine CA (1986)
Residency: Massachusetts General Hospital MA (1982)
M.D.: Harvard, Medicine (1980)
Ph.D.: M.I.T., Physics (1973)
A.B.: Princeton, Physics (1967)
Board Certification: Internal Medicine, American Board of Internal Medicine (1983)
View All 7

Patents

  • Gilbert Chu, Virginia Tusher, Jean Tang, Kerry Rieger, Wan Jen Hong, Robert Tibshirani. "United States Patent 7,465,542 Methods and compositions for determining treatment toxicity", Leland Stanford Junior University, Dec 16, 2008
  • Gilbert Chu, Robert Tibshirani, Virginia Tusher. "United States Patent 7,363,165 Significance analysis of microarrays", Leland Stanford Junior University, Apr 22, 2008
  • Gilbert Chu, Douglas Vollrath, Ronald Davis. "United States Patent 5,165,898 Electrophoresis using contour-clamped electric fields", Leland Stanford Junior University,, Nov 24, 1992
  • Gilbert Chu. "United States Patent 8,263,332 Mismatched end DNA ligase", Leland Stanford Junior University, Sep 11, 2012

Research & Scholarship

Current Research and Scholarly Interests

Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves three areas that interact with each other: repair of ionizing radiation damage, repair of ultraviolet radiation damage, and transcriptional responses to DNA damage in cancer patients.

To understand how cells target DNA damaged by ultraviolet radiation for nucleotide excision repair, we identified UV-damaged DNA binding activity (UV-DDB). We showed that the p48 gene, encoding one of the subunits of UV-DDB, is mutated in xeroderma pigmentosum group E patients, and transcriptionally activated after DNA damage by p53. UV-DDB enhances global genomic repair and suppresses UV-induced mutagenesis.

To understand how cells repair DNA damaged by ionizing radiation, we study the non-homologous end joining pathway, which repairs double-strand breaks produced by ionizing radiation and V(D)J recombination. We wish to understand how joining optimizes the preservation of DNA sequence. We are currently studying the joining reaction with purified proteins to determine how the DNA ends are brought together, processed, and rejoined.

We have used microarrays to study the transcriptional response to ionizing radiation in lymphoblastoid cells from cancer patients with adverse reactions to radiation therapy. To interpret the microarray data, we invented new methods to analyze microarray data, including SAM (Significance Analysis of Microarrays). We successfully identified genes whose transcriptional responses predict risk for radiation toxicity. These results provide hope that treatment toxicity will soon be predicted by clinical tests.

Teaching

Courses

2013-14

Prior Year Coursescourses of Gilbert Chu

Graduate and Fellowship Program Affiliations

Publications

Publications

Publication tag cloud

Publication Topics

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