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Robert Negrin

Academic Appointments

  • Professor of Medicine (Blood and Marrow Transplantation)

Key Documents

Contact Information

  • Clinical Offices
    Blood and Marrow Transplant Clinic 875 Blake Wilbur Dr Clinic C Stanford, CA 94305
    Tel Work (650) 498-6000 Fax (650) 725-5030
  • Academic Offices
    Personal Information
    Email Tel (650) 723-0822
    Administrative Contact
    Sara Clark Administrative Associate Tel Work (650) 725-4959
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Cancer> Blood and Marrow Transplant
  • Cancer> Hematology
  • Blood and Marrow Transplantation
  • Hematology

Administrative Appointments

  • Medical Director, Clinical Bone Marrow Transplantation Laboratory (1990 - present)
  • Division Chief, Blood and Marrow Transplant Program, Stanford University (2000 - present)

Honors and Awards

  • Fellowship, Damon Runyon-Walter Winchell Cancer Fund (1988-1991)
  • Fellow, Jose Carreras International Leukemia Foundation (1993-1996)
  • President, International Society of Cellular Therapy (2000-2002)
  • Distinguished Clinical Scientist Award, Doris Duke Foundation (2004-2009)
  • President, American Society of Blood and Marrow Transplantation (2006-2007)
  • Member, Association of American Physicians (AAP) (2008)
View All 7honors and awards of Robert Negrin

Boards, Advisory Committees, Professional Organizations

  • Member, American Society of Hematology
  • Member, International Society of Experimental Hematology
  • Member, American College of Physicians
  • Member, American Association for the Advancement of Science
  • Member, International Society for Cellular Therapy
  • Member, American Society for Blood and Marrow Transplantation
View All 7professional activities and affiliations of Robert Negrin

Professional Education

Residency: Stanford University School of Medicine CA (1986)
Internship: Stanford University School of Medicine CA (1985)
Fellowship: Stanford University School of Medicine CA (1987)
Board Certification: Hematology, American Board of Internal Medicine (1992)
Board Certification: Internal Medicine, American Board of Internal Medicine (1987)
Medical Education: Harvard Medical School MA (1984)
View All 7

Community and International Work

Courses

2013-14

Prior Year Coursescourses of Robert Negrin

Scientific Focus

Current Research and Scholarly Interests

Research projects in our laboratory are aimed at studying the biology of cell populations capable of inducing or suppressing graft vs host disease as well as cells capable of promoting a graft vs tumor effect. In particular we are studying:

1) The clinical utility of expanded cytotoxic cells for immunotherapy. We have developed animal models utilizing mice with severe combined immunodeficiency (SCID) which will accept human tumor cells or murine model systems of syngeneic and allogeneic transplantation. In some instances the tumor cells are transfected with the bioluminescent marker luciferase so that the tumor cell growth can be quantitatively tracked in living animals. Using these model system we are studying the clinical efficacy of the expanded cytotoxic cells.

2) The interaction between the cytotoxic effector cells and a variety of tumor cell targets is under study. The role of granzyme/perforin and fas mediated pathways as well as the cell surface molecule NKG2D in cytotoxicity is under study.

3) We are exploring the biological impact of phenotypically defined populations of regulatory T cells on graft vs host disease and graft vs tumor reactions.

4) We are utilizing bioluminescent techniques to study these complex biological processes by either labelling the tumor or effector cell populations with the light emitting luciferase gene such that small numbers of cells can be tracked non-invasively, sensively and quantitatively.

Publications

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Publication Topics

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