Cancer Institute A national cancer institute
designated cancer center
Email this profile
Portrait View Larger

Mark Pegram

Academic Appointments

  • Susy Yuan-Huey Hung Professor

Key Documents

Contact Information

  • Clinical Offices
    Stanford Womens Cancer Center 900 Blake Wilbur Stanford, CA 94305
    Tel Work (650) 498-6004 Fax (650) 490-7237
  • Academic Offices
    Personal Information
    Email Tel (650) 723-5801
    Administrative Contact
    Connie Osborne Administrative Assistant Tel Work 650-723-5801
    Not for medical emergencies or patient use

Professional Overview


Mark D. Pegram, MD, is the first director of the Breast Cancer Oncology Program at Stanford Women’s Cancer Center. He is also the co-director of Stanford’s Molecular Therapeutics Program. He is a renowned clinician and scholar in breast cancer research and a leader in translational medicine. Dr. Pegram played a major role in developing the drug Herceptin as a treatment for HER2-positive breast cancer, which constitutes about 20 percent of all cases. His laboratory experiments demonstrated that combining Herceptin with chemotherapy effectively killed cancer cells that overproduced the growth factor HER2. Dr. Pegram and others then conducted clinical trials showing that Herceptin improved survival rates and even cured some breast cancer patients. This remains one of the premier examples of bench-to-bedside translational research. Dr. Pegram’s current research efforts include a continued focus on the cancer-associated gene that encodes HER2 and developing new ways to target cancer cells expressing this protein. He is also pursuing strategies to target estrogen receptors, implicated in some 70 percent of all breast cancer cases.
Dr. Pegram earned his undergraduate and medical degrees from the University of North Carolina before joining the faculty of the University of California, Los Angeles. He spent five years at the University of Miami Miller School of Medicine, where he was a Sylvester Chair professor of medicine in the Braman Family Breast Cancer Institute and associate director for clinical research in the University’s Sylvester Comprehensive Cancer Center. He joined the Stanford faculty in 2012.

Clinical Focus

  • Cancer> Breast Cancer
  • molecular therapeutics
  • Medical Oncology

Administrative Appointments

  • Co-Director, Translational Oncology Research Program @ Stanford (TOP@S), Stanford Cancer Institute (2013 - present)
  • Director, Stanford Breast Oncology Program, Stanford Cancer Institute (2012 - present)
  • Associate Director for Clinical Research, Stanford Cancer Institute (2013 - present)

Honors and Awards

  • The Celebrity Cruises Award, The Breast Cancer Research Foundation (2013-2014)
  • 2012 Keynote Lecture, American Radium Society 94th Annual Meeting, American Radium Society (29 April 2012)
  • Chair, Department of Defense Breast Cancer Research Program Integration Panel, Congressionally Directed Medical Research Programs, U.S. Army Research and Materiel Command (2012)
  • John G. Kuhn Lecture, Hematology/Oncology Pharmacy Association (21 March 2013)
  • 6th Annual Connie Moskow Memorial Lectureship, Robert H. Lurie Comprehensive Cancer Center of Northwestern University (11 May 2012)
  • Sylvester Outstanding Cancer Research Award, University of Miami Sylvester Comprehensive Cancer Center (13 May 2011)

Professional Education

Board Certification: Medical Oncology, American Board of Internal Medicine (1993)
Board Certification: Internal Medicine, American Board of Internal Medicine (1989)
Internship: Univ Of Texas Southwestern TX (1987)
Residency: Univ Of Texas Southwestern TX (1987)
Fellowship: UCLA - School of Medicine CA (1993)
Medical Education: University of North Carolina NC (1986)

Community and International Work



Postdoctoral Advisees

Jessica Bockhorn

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

Molecular mechanisms of targeted therapy resistance in breast and other cancers


Publication tag cloud

Publication Topics

View All 53

Stanford Medicine Resources:

Footer Links: