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Manish J. Butte, MD PhD

Academic Appointments

  • Assistant Professor of Pediatrics (Immunology)

Key Documents

Contact Information

  • Clinical Offices
    Pediatric Allergy and Immunology 730 Welch Rd Stanford, CA 94305
    Tel Work (650) 723-0290
  • Academic Offices
    Personal Information
    Email Tel (650) 721-1324
    Courtney Scheuch Administrative Associate Tel Work 650-498-6073
    Not for medical emergencies or patient use


Clinical Focus

  • Allergy and Immunology
  • Pediatric Allergy/Immun

Academic Appointments

Administrative Appointments

  • Assistant Professor, Pediatrics Immunology & Allergy (2009 - present)

Honors and Awards

  • Award, Bio-X Interdisciplinary Award (2010)
  • Scholar, SPARK (2010-11,11-13,14-15)
  • Fellow, American Academy of Pediatrics (2008-)

Boards, Advisory Committees, Professional Organizations

  • Defense Sciences Study Group, US Department of Defense (2014 - present)
  • Education Committee, Clinical Immunology Society (2014 - present)
  • Annual Retreat Co-Chair, Stanford Immunology (2012 - 2013)

Professional Education

Board Certification: Pediatrics, American Board of Pediatrics (2004)
Fellowship: Children's Hospital Boston MA (06/2006)
Board Certification: Allergy and Immunology, American Board of Allergy and Immunology (2005)
Residency: Children's Hospital of Philadelphia PA (06/2003)
Ph.D.: UCSF, Biophysics (2000)
Medical Education: Brown University - School of Medicine RI (06/1996)
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  • Manish J Butte, Marc Amor Bruce, Jianwei Liu. "United States Patent US 13/307,882 Atomic force microscope manipulation of living cells", The Board Of Trustees Of The Leland Stanford Junior University, Nov 30, 2010
  • Meital Reches, Michael D. Dickey, Manish J. Butte, George M. Whitesides. "United States Patent PCT/US2009/038702 Cotton thread as a low-cost multi-assay diagnostic platform", President And Fellows Of Harvard College, Mar 27, 2008
  • Arlene H. Sharpe, Manish J. Butte, Shinji Oyama. "United States Patent PCT/US2011/020046 Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof", President And Fellows Of Harvard College, Jan 4, 2010
  • Manish J. BUTTE, John J. LeBlanc. "United States Patent US 13/317,180 Microfluidic Waveguide Detector", The Board Of Trustees Of The Leland Stanford Junior University, Oct 12, 2010
  • George M. Whitesides, Scott T. PHILLIPS, Andreas W. Martinez, Manish J. BUTTE, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. VELLA, Emanuel CARRILHO, Katherine A. MIRICA, Yanyan LIU,. "United States Patent US 13/730,028 Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same", President And Fellows Of Harvard College, Oct 18, 2006

Research & Scholarship

Current Research and Scholarly Interests

Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.

Projects in the lab include:
1) Atomic force microscopy of T cells
2) Mechanobiology of biomaterials, cardiac cells, endothelial cells, and cancers
3) Discovery and characterization of new inhibitory pathways of T cells
4) High resolution visualization of receptor and ligands in the T cell immunological synapse
5) Manipulation of single-receptors on T cells to control activation versus tolerance
6) Development of diagnostic tools for immune monitoring and autoimmune diseases (such as Type 1 diabetes and multiple sclerosis)
7) Characterization of self-like antigens and their roles in autoimmunity (in multiple sclerosis and Type 1 diabetes)




Prior Year Coursescourses of Manish Butte



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Publication Topics

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