Annelise E. Barron
Publication Details
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Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.
Curr Opin Chem Biol. 2002; (6): 872-7
Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.
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