Donna M. Bouley
Publication Details
-
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.
Circulation. 2003; (19): 2304-7
Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that delta-protein kinase C (deltaPKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for deltaPKC during reperfusion only, using an in vivo porcine model of AMI.
Help
Trial Administration