Anne Brunet
Publication Details
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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Curr Biol. 2007; (19): 1646-56
Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. However, the molecular mechanisms underlying the benefits of DR on longevity are still poorly characterized. AMP-activated protein kinase (AMPK) is activated by a decrease in energy levels, raising the possibility that AMPK might mediate lifespan extension by DR.
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