Publication Details

Reduced cold pain tolerance in chronic pain patients following opioid detoxification.

Younger J, Barelka P, Carroll I, Kaplan K, Chu L, Prasad R, Gaeta R, Mackey S. Pain Med. 2008; 9 (8): 1158-63

One potential consequence of chronic opioid analgesic administration is a paradoxical increase of pain sensitivity over time. Little scientific attention has been given to how cessation of opioid medication affects the hyperalgesic state. In this study, we examined the effects of opioid tapering on pain sensitivity in chronic pain patients.

PubMedID: 18564998