Robert Negrin
Publication Details
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Biology and clinical effects of natural killer cells in allogeneic transplantation.
Curr Opin Oncol. 2010; (2): 130-7
Following allogeneic hematopoietic cell transplantation, donor-derived natural killer (NK) cells target recipient hematopoietic cells, resulting in an antileukemia effect and a lower incidence of graft rejection. NK cells do not mediate and may diminish graft versus host disease. Here we review the determinants of NK cell alloreactivity and their implications for adoptive NK cell therapy.
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