Matthew Bogyo
Publication Details
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Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs.
Chem Biol. 2000; (1): 27-38
The lysosomal cysteine proteases of the papain family are some of the best studied proteolytic enzymes. Small-molecule inhibitors and fluorogenic substrate mimics have been used to probe the physiological roles of these proteases. A high degree of homology between family members and overlap in substrate specificity have made elucidating individual protease function, expression and activity difficult.
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