Matthew Bogyo
Publication Details
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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
Chem Biol. 2000; (8): 569-81
Analysis of global changes in gene transcription and translation by systems-based genomics and proteomics approaches provides only indirect information about protein function. In many cases, enzymatic activity fails to correlate with transcription or translation levels. Therefore, a direct method for broadly determining activities of an entire class of enzymes on a genome-wide scale would be of great utility.
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