Robert Lowsky
Publication Details
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Nonmyeloablative conditioning with total lymphoid irradiation and antithymocyte globulin: an update.
Curr Opin Hematol. 2009; (6): 460-5
The immune modulatory effects of total lymphoid irradiation (TLI) for graft-versus-host disease (GVHD) protection and transplantation tolerance following allogeneic bone marrow and organ transplantation have been studied for years in animal models. In preclinical models nonmyeloablative TLI conditioning alters residual host T cell subsets to favor regulatory natural killer T cells that suppress GVHD and prevent organ allograft rejection. These preclinical models have been recently adapted to human transplantation.
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