Russ B. Altman
Publication Details
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Are predicted structures good enough to preserve functional sites?
Structure. 1999; (6): 643-50
A principal goal of structure prediction is the elucidation of function. We have studied the ability of computed models to preserve the microenvironments of functional sites. In particular, 653 model structures of a calcium-binding protein (generated using an ab initio folding protocol) were analyzed, and the degree to which calcium-binding sites were recognizable was assessed.
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