Martin Brown
Publication Details
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Toxicology of daily administration to mice of the radiation potentiator SR 4233 (WIN 59075).
Radiother Oncol. 1993; (1): 79-81
We have investigated the feasibility of administration of an effective dose of the hypoxic cytotoxin, SR 4233, Monday-Friday daily for 6 weeks. From a thorough hematological, histopathological and clinical chemistry evaluation throughout the course and during a 3-week recovery period, we conclude that daily administration of a radiopotentiating dose of SR 4233 in mice is well tolerated and that bone marrow suppression is likely to be the dose-limiting toxicity.
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