Martin Brown
Publication Details
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Therapeutic targets in radiotherapy.
Int J Radiat Oncol Biol Phys. 2001; (2): 319-26
Enormous progress has been made in the past 5 years in our understanding of the gene products governing the response of mammalian cells to ionizing radiation. Many of these are potential targets for enhancing the effectiveness of radiotherapy. However, a major barrier to such efforts is the requirement for a preferential effect on tumor vs. normal cells. Such a requirement can only come about by exploiting a known difference between tumor and normal cells.
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