Robert W. Carlson
Publication Details
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Impact of omeprazole on the plasma clearance of methotrexate.
Cancer Chemother Pharmacol. 1993; (1): 82-4
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
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