Cancer Institute– A national cancer institute
designated cancer center

Mark L. Gonzalgo, M.D., Ph.D.

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Publication Details

  • Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients.

    Friedrich MG, Weisenberger DJ, Cheng JC, Chandrasoma S, Siegmund KD, Gonzalgo ML, Toma MI, Huland H, Yoo C, Tsai YC, Nichols PW, Bochner BH, Jones PA, Liang G. Clin Cancer Res. 2004; 10 (22): 7457-65

    There is increasing evidence for a fundamental role for epigenetic silencing of apoptotic pathways in cancer. Changes in DNA methylation can be detected with a high degree of sensitivity, so we used the MethyLight assay to determine how methylation patterns of apoptosis-associated genes change during bladder carcinogenesis and whether DNA methylation could be detected in urine sediments.

    PubMedID: 15569975

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