Roeland Nusse
Publication Details
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The Wnt gene family in tumorigenesis and in normal development.
J Steroid Biochem Mol Biol. 1992; (1-3): 9-12
Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis.
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